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Guang Lei
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DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, ...
Nature 593 (7860), 586-590, 2021
8962021
Targeting ferroptosis as a vulnerability in cancer
G Lei, L Zhuang, B Gan
Nature Reviews Cancer 22 (7), 381-396, 2022
8192022
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
G Lei, Y Zhang, P Koppula, X Liu, J Zhang, SH Lin, JA Ajani, Q Xiao, ...
Cell research 30 (2), 146-162, 2020
7442020
mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation
Y Zhang, RV Swanda, L Nie, X Liu, C Wang, H Lee, G Lei, C Mao, ...
Nature communications 12 (1), 1-14, 2021
3782021
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
X Liu, L Nie, Y Zhang, Y Yan, C Wang, M Colic, K Olszewski, A Horbath, ...
Nature cell biology 25 (3), 404-414, 2023
3282023
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
X Liu, K Olszewski, Y Zhang, EW Lim, J Shi, X Zhang, J Zhang, H Lee, ...
Nature cell biology 22 (4), 476-486, 2020
2862020
Ferroptosis, radiotherapy, and combination therapeutic strategies
G Lei, C Mao, Y Yan, L Zhuang, B Gan
Protein & cell 12 (11), 836-857, 2021
2082021
A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers
P Koppula, G Lei, Y Zhang, Y Yan, C Mao, L Kondiparthi, J Shi, X Liu, ...
Nature communications 13 (1), 2206, 2022
1732022
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
T Hong, G Lei, X Chen, H Li, X Zhang, N Wu, Y Zhao, Y Zhang, J Wang
Redox biology 42, 101928, 2021
1712021
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
G Lei, Y Zhang, T Hong, X Zhang, X Liu, C Mao, Y Yan, P Koppula, ...
Oncogene 40 (20), 3533-3547, 2021
1212021
mTORC1 and ferroptosis: regulatory mechanisms and therapeutic potential
G Lei, L Zhuang, B Gan
Bioessays 43 (8), 2100093, 2021
462021
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
Y Yan, H Teng, Q Hang, L Kondiparthi, G Lei, A Horbath, X Liu, C Mao, ...
Nature communications 14 (1), 3673, 2023
432023
The beneficial role of sunitinib in tumor immune surveillance by regulating tumor PD‐L1
H Li, X Kuang, L Liang, Y Ye, YC Zhang, J Li, F Ma, J Tao, G Lei, S Zhao, ...
Advanced Science 8 (2), 2001596, 2021
422021
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma
S Song, Q Chen, Y Li, G Lei, A Scott, L Huo, CY Li, JS Estrella, A Correa, ...
Gut 70 (12), 2238-2248, 2021
402021
H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death
Y Zhang, J Shi, X Liu, Z Xiao, G Lei, H Lee, P Koppula, W Cheng, C Mao, ...
Cancer research 80 (11), 2243-2256, 2020
302020
KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
P Koppula, K Olszewski, Y Zhang, L Kondiparthi, X Liu, G Lei, M Das, ...
Iscience 24 (6), 2021
272021
Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, ...
Nature 596 (7873), E13-E13, 2021
172021
Efficacy and safety of apatinib plus vinorelbine in patients with wild-type advanced non–small cell lung cancer after second-line treatment failure: a nonrandomized clinical trial
X Zhang, Y Xiong, Q Xia, F Wu, L Liu, Y Zhou, L Zeng, C Zhou, C Xia, ...
JAMA Network Open 3 (3), e201226-e201226, 2020
142020
PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity
G Lei, A Horbath, Z Li, B Gan
Cancer Communications 42 (7), 583, 2022
122022
Multi-omics characterization and therapeutic liability of ferroptosis in melanoma
Y He, Y Dong, Y Chen, G Zhang, H Zhang, G Lei, Y Du, X Chen, Y Ye, ...
Signal Transduction and Targeted Therapy 7 (1), 268, 2022
112022
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