DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, ... Nature 593 (7860), 586-590, 2021 | 896 | 2021 |
Targeting ferroptosis as a vulnerability in cancer G Lei, L Zhuang, B Gan Nature Reviews Cancer 22 (7), 381-396, 2022 | 819 | 2022 |
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression G Lei, Y Zhang, P Koppula, X Liu, J Zhang, SH Lin, JA Ajani, Q Xiao, ... Cell research 30 (2), 146-162, 2020 | 744 | 2020 |
mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation Y Zhang, RV Swanda, L Nie, X Liu, C Wang, H Lee, G Lei, C Mao, ... Nature communications 12 (1), 1-14, 2021 | 378 | 2021 |
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis X Liu, L Nie, Y Zhang, Y Yan, C Wang, M Colic, K Olszewski, A Horbath, ... Nature cell biology 25 (3), 404-414, 2023 | 328 | 2023 |
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer X Liu, K Olszewski, Y Zhang, EW Lim, J Shi, X Zhang, J Zhang, H Lee, ... Nature cell biology 22 (4), 476-486, 2020 | 286 | 2020 |
Ferroptosis, radiotherapy, and combination therapeutic strategies G Lei, C Mao, Y Yan, L Zhuang, B Gan Protein & cell 12 (11), 836-857, 2021 | 208 | 2021 |
A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers P Koppula, G Lei, Y Zhang, Y Yan, C Mao, L Kondiparthi, J Shi, X Liu, ... Nature communications 13 (1), 2206, 2022 | 173 | 2022 |
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer T Hong, G Lei, X Chen, H Li, X Zhang, N Wu, Y Zhao, Y Zhang, J Wang Redox biology 42, 101928, 2021 | 171 | 2021 |
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity G Lei, Y Zhang, T Hong, X Zhang, X Liu, C Mao, Y Yan, P Koppula, ... Oncogene 40 (20), 3533-3547, 2021 | 121 | 2021 |
mTORC1 and ferroptosis: regulatory mechanisms and therapeutic potential G Lei, L Zhuang, B Gan Bioessays 43 (8), 2100093, 2021 | 46 | 2021 |
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells Y Yan, H Teng, Q Hang, L Kondiparthi, G Lei, A Horbath, X Liu, C Mao, ... Nature communications 14 (1), 3673, 2023 | 43 | 2023 |
The beneficial role of sunitinib in tumor immune surveillance by regulating tumor PD‐L1 H Li, X Kuang, L Liang, Y Ye, YC Zhang, J Li, F Ma, J Tao, G Lei, S Zhao, ... Advanced Science 8 (2), 2001596, 2021 | 42 | 2021 |
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma S Song, Q Chen, Y Li, G Lei, A Scott, L Huo, CY Li, JS Estrella, A Correa, ... Gut 70 (12), 2238-2248, 2021 | 40 | 2021 |
H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death Y Zhang, J Shi, X Liu, Z Xiao, G Lei, H Lee, P Koppula, W Cheng, C Mao, ... Cancer research 80 (11), 2243-2256, 2020 | 30 | 2020 |
KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition P Koppula, K Olszewski, Y Zhang, L Kondiparthi, X Liu, G Lei, M Das, ... Iscience 24 (6), 2021 | 27 | 2021 |
Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, ... Nature 596 (7873), E13-E13, 2021 | 17 | 2021 |
Efficacy and safety of apatinib plus vinorelbine in patients with wild-type advanced non–small cell lung cancer after second-line treatment failure: a nonrandomized clinical trial X Zhang, Y Xiong, Q Xia, F Wu, L Liu, Y Zhou, L Zeng, C Zhou, C Xia, ... JAMA Network Open 3 (3), e201226-e201226, 2020 | 14 | 2020 |
PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity G Lei, A Horbath, Z Li, B Gan Cancer Communications 42 (7), 583, 2022 | 12 | 2022 |
Multi-omics characterization and therapeutic liability of ferroptosis in melanoma Y He, Y Dong, Y Chen, G Zhang, H Zhang, G Lei, Y Du, X Chen, Y Ye, ... Signal Transduction and Targeted Therapy 7 (1), 268, 2022 | 11 | 2022 |