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D Paul Harkin
D Paul Harkin
Professor of Molecular Oncology Queens University Belfast
Verified email at qub.ac.uk
Title
Cited by
Cited by
Year
5-fluorouracil: mechanisms of action and clinical strategies
DB Longley, DP Harkin, PG Johnston
Nature reviews cancer 3 (5), 330-338, 2003
58652003
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
DP Harkin, JM Bean, D Miklos, YH Song, VB Truong, C Englert, ...
Cell 97 (5), 575-586, 1999
7471999
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis
JE Quinn, RD Kennedy, PB Mullan, PM Gilmore, M Carty, PG Johnston, ...
Cancer research 63 (19), 6221-6228, 2003
5892003
The role of BRCA1 in the cellular response to chemotherapy
RD Kennedy, JE Quinn, PB Mullan, PG Johnston, DP Harkin
Journal of the National Cancer Institute 96 (22), 1659-1668, 2004
5762004
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
KE Nichols, DP Harkin, S Levitz, M Krainer, KA Kolquist, C Genovese, ...
Proceedings of the National Academy of Sciences 95 (23), 13765-13770, 1998
5741998
Heterozygous ATM mutations do not contribute to early onset of breast cancer
MG Fitzgerald, JM Bean, SR Hegde, H Unsal, DJ Macdonald, DP Harkin, ...
Nature genetics 15 (3), 307-310, 1997
4471997
Activation of STING-dependent innate immune signaling by S-phase-specific DNA damage in breast cancer
EE Parkes, SM Walker, LE Taggart, N McCabe, LA Knight, R Wilkinson, ...
Journal of the National Cancer Institute 109 (1), djw199, 2017
4052017
The role of BRCA1 in transcriptional regulation and cell cycle control
PB Mullan, JE Quinn, DP Harkin
Oncogene 25 (43), 5854-5863, 2006
3762006
BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy
JE Quinn, CR James, GE Stewart, JM Mulligan, P White, GKF Chang, ...
Clinical cancer research 13 (24), 7413-7420, 2007
2852007
Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.
MG FitzGerald, DP Harkin, S Silva-Arrieta, DJ MacDonald, LC Lucchina, ...
Proceedings of the National Academy of Sciences 93 (16), 8541-8545, 1996
2601996
BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer
CR James, JE Quinn, PB Mullan, PG Johnston, DP Harkin
The oncologist 12 (2), 142-150, 2007
2422007
Molecular basis for estrogen receptor α deficiency in BRCA1-linked breast cancer
AM Hosey, JJ Gorski, MM Murray, JE Quinn, WY Chung, GE Stewart, ...
JNCI: Journal of the National Cancer Institute 99 (22), 1683-1694, 2007
2292007
Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue
RD Kennedy, M Bylesjo, P Kerr, T Davison, JM Black, EW Kay, RJ Holt, ...
Journal of Clinical Oncology 29 (35), 4620-4626, 2011
2282011
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery
S Tejpar, M Bertagnolli, F Bosman, HJ Lenz, L Garraway, F Waldman, ...
The oncologist 15 (4), 390-404, 2010
2172010
BRCA 1, a ‘complex’protein involved in the maintenance of genomic stability
KI Savage, DP Harkin
The FEBS journal 282 (4), 630-646, 2015
2152015
RNA expression analysis from formalin fixed paraffin embedded tissues
SM Farragher, A Tanney, RD Kennedy, D Paul Harkin
Histochemistry and cell biology 130 (3), 435-445, 2008
2142008
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents
PB Mullan, JE Quinn, PM Gilmore, S McWilliams, H Andrews, C Gervin, ...
Oncogene 20 (43), 6123-6131, 2001
1982001
Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability
KI Savage, JJ Gorski, EM Barros, GW Irwin, L Manti, AJ Powell, ...
Molecular cell 54 (3), 445-459, 2014
1942014
Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling
PJ Maxwell, DB Longley, T Latif, J Boyer, W Allen, M Lynch, U McDermott, ...
Cancer research 63 (15), 4602-4606, 2003
1752003
The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates
DB Longley, J Boyer, WL Allen, T Latif, PR Ferguson, PJ Maxwell, ...
Cancer research 62 (9), 2644-2649, 2002
1522002
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