5-fluorouracil: mechanisms of action and clinical strategies DB Longley, DP Harkin, PG Johnston Nature reviews cancer 3 (5), 330-338, 2003 | 5865 | 2003 |
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1 DP Harkin, JM Bean, D Miklos, YH Song, VB Truong, C Englert, ... Cell 97 (5), 575-586, 1999 | 747 | 1999 |
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis JE Quinn, RD Kennedy, PB Mullan, PM Gilmore, M Carty, PG Johnston, ... Cancer research 63 (19), 6221-6228, 2003 | 589 | 2003 |
The role of BRCA1 in the cellular response to chemotherapy RD Kennedy, JE Quinn, PB Mullan, PG Johnston, DP Harkin Journal of the National Cancer Institute 96 (22), 1659-1668, 2004 | 576 | 2004 |
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome KE Nichols, DP Harkin, S Levitz, M Krainer, KA Kolquist, C Genovese, ... Proceedings of the National Academy of Sciences 95 (23), 13765-13770, 1998 | 574 | 1998 |
Heterozygous ATM mutations do not contribute to early onset of breast cancer MG Fitzgerald, JM Bean, SR Hegde, H Unsal, DJ Macdonald, DP Harkin, ... Nature genetics 15 (3), 307-310, 1997 | 447 | 1997 |
Activation of STING-dependent innate immune signaling by S-phase-specific DNA damage in breast cancer EE Parkes, SM Walker, LE Taggart, N McCabe, LA Knight, R Wilkinson, ... Journal of the National Cancer Institute 109 (1), djw199, 2017 | 405 | 2017 |
The role of BRCA1 in transcriptional regulation and cell cycle control PB Mullan, JE Quinn, DP Harkin Oncogene 25 (43), 5854-5863, 2006 | 376 | 2006 |
BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy JE Quinn, CR James, GE Stewart, JM Mulligan, P White, GKF Chang, ... Clinical cancer research 13 (24), 7413-7420, 2007 | 285 | 2007 |
Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. MG FitzGerald, DP Harkin, S Silva-Arrieta, DJ MacDonald, LC Lucchina, ... Proceedings of the National Academy of Sciences 93 (16), 8541-8545, 1996 | 260 | 1996 |
BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer CR James, JE Quinn, PB Mullan, PG Johnston, DP Harkin The oncologist 12 (2), 142-150, 2007 | 242 | 2007 |
Molecular basis for estrogen receptor α deficiency in BRCA1-linked breast cancer AM Hosey, JJ Gorski, MM Murray, JE Quinn, WY Chung, GE Stewart, ... JNCI: Journal of the National Cancer Institute 99 (22), 1683-1694, 2007 | 229 | 2007 |
Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue RD Kennedy, M Bylesjo, P Kerr, T Davison, JM Black, EW Kay, RJ Holt, ... Journal of Clinical Oncology 29 (35), 4620-4626, 2011 | 228 | 2011 |
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery S Tejpar, M Bertagnolli, F Bosman, HJ Lenz, L Garraway, F Waldman, ... The oncologist 15 (4), 390-404, 2010 | 217 | 2010 |
BRCA 1, a ‘complex’protein involved in the maintenance of genomic stability KI Savage, DP Harkin The FEBS journal 282 (4), 630-646, 2015 | 215 | 2015 |
RNA expression analysis from formalin fixed paraffin embedded tissues SM Farragher, A Tanney, RD Kennedy, D Paul Harkin Histochemistry and cell biology 130 (3), 435-445, 2008 | 214 | 2008 |
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents PB Mullan, JE Quinn, PM Gilmore, S McWilliams, H Andrews, C Gervin, ... Oncogene 20 (43), 6123-6131, 2001 | 198 | 2001 |
Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability KI Savage, JJ Gorski, EM Barros, GW Irwin, L Manti, AJ Powell, ... Molecular cell 54 (3), 445-459, 2014 | 194 | 2014 |
Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling PJ Maxwell, DB Longley, T Latif, J Boyer, W Allen, M Lynch, U McDermott, ... Cancer research 63 (15), 4602-4606, 2003 | 175 | 2003 |
The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates DB Longley, J Boyer, WL Allen, T Latif, PR Ferguson, PJ Maxwell, ... Cancer research 62 (9), 2644-2649, 2002 | 152 | 2002 |