| A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ... ACS chemical biology 11 (3), 772-781, 2016 | 234 | 2016 |
| LLY-283, a potent and selective inhibitor of arginine methyltransferase 5, PRMT5, with antitumor activity ZQ Bonday, GS Cortez, MJ Grogan, S Antonysamy, K Weichert, ... ACS medicinal chemistry letters 9 (7), 612-617, 2018 | 148 | 2018 |
| Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein MS Eram, SP Bustos, E Lima-Fernandes, A Siarheyeva, G Senisterra, ... Journal of Biological Chemistry 289 (17), 12177-12188, 2014 | 126 | 2014 |
| A potent, selective and cell‐active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) HÜ Kaniskan, MM Szewczyk, Z Yu, MS Eram, X Yang, K Schmidt, X Luo, ... Angewandte Chemie 127 (17), 5255-5259, 2015 | 115 | 2015 |
| The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity KD Bromberg, TRH Mitchell, AK Upadhyay, CG Jakob, MA Jhala, ... Nature chemical biology 13 (3), 317-324, 2017 | 111 | 2017 |
| Discovery of a dual PRMT5–PRMT7 inhibitor D Smil, MS Eram, F Li, S Kennedy, MM Szewczyk, PJ Brown, ... ACS medicinal chemistry letters 6 (4), 408-412, 2015 | 103 | 2015 |
| TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma K Nakayama, MM Szewczyk, C dela Sena, H Wu, A Dong, H Zeng, F Li, ... Oncotarget 9 (26), 18480, 2018 | 97 | 2018 |
| Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response MM Szewczyk, Y Ishikawa, S Organ, N Sakai, F Li, L Halabelian, S Ackloo, ... Nature communications 11 (1), 2396, 2020 | 83 | 2020 |
| Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6 Y Shen, MM Szewczyk, MS Eram, D Smil, HU Kaniskan, ... Journal of medicinal chemistry 59 (19), 9124-9139, 2016 | 78 | 2016 |
| Structural and functional consequences of the STAT5BN642H driver mutation ED de Araujo, F Erdogan, HA Neubauer, D Meneksedag-Erol, ... Nature communications 10 (1), 2517, 2019 | 72 | 2019 |
| Decarboxylation of pyruvate to acetaldehyde for ethanol production by hyperthermophiles MS Eram, K Ma Biomolecules 3 (3), 578-596, 2013 | 63 | 2013 |
| Targeting human SET1/MLL family of proteins M Vedadi, L Blazer, MS Eram, D Barsyte‐Lovejoy, CH Arrowsmith, ... Protein Science 26 (4), 662-676, 2017 | 58 | 2017 |
| Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2 MS Eram, E Kuznetsova, F Li, E Lima-Fernandes, S Kennedy, I Chau, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1850 (9), 1842-1848, 2015 | 50 | 2015 |
| Discovery of a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor by virtual screening R Ferreira de Freitas, MS Eram, D Smil, MM Szewczyk, S Kennedy, ... Journal of medicinal chemistry 59 (14), 6838-6847, 2016 | 49 | 2016 |
| Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1 S Qin, Y Liu, W Tempel, MS Eram, C Bian, K Liu, G Senisterra, L Crombet, ... Nature communications 5 (1), 3952, 2014 | 43 | 2014 |
| Discovery of a potent class I protein arginine methyltransferase fragment inhibitor R Ferreira de Freitas, MS Eram, MM Szewczyk, H Steuber, D Smil, H Wu, ... Journal of medicinal chemistry 59 (3), 1176-1183, 2016 | 39 | 2016 |
| Structural basis of arginine asymmetrical dimethylation by PRMT6 H Wu, W Zheng, MS Eram, M Vhuiyan, A Dong, H Zeng, H He, P Brown, ... Biochemical Journal 473 (19), 3049-3063, 2016 | 37 | 2016 |
| PR domain-containing protein 7 (PRDM7) is a histone 3 lysine 4 trimethyltransferase LL Blazer, E Lima-Fernandes, E Gibson, MS Eram, P Loppnau, ... Journal of Biological Chemistry 291 (26), 13509-13519, 2016 | 36 | 2016 |
| Discovery of a chemical probe for PRDM9 A Allali-Hassani, MM Szewczyk, D Ivanochko, SL Organ, J Bok, JSY Ho, ... Nature communications 10 (1), 5759, 2019 | 30 | 2019 |
| Discovery of potent and selective allosteric inhibitors of protein arginine methyltransferase 3 (PRMT3) HU Kaniskan, MS Eram, K Zhao, MM Szewczyk, X Yang, K Schmidt, ... Journal of Medicinal Chemistry 61 (3), 1204-1217, 2018 | 29 | 2018 |
Matthieu SchapiraAssociate Professor, University of TorontoVerified email at utoronto.ca
