|Mitotic progression following DNA damage enables pattern recognition within micronuclei|
SM Harding, JL Benci, J Irianto, DE Discher, AJ Minn, RA Greenberg
Nature 548 (7668), 466-470, 2017
|Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival|
T Harada, J Swift, J Irianto, JW Shin, KR Spinler, A Athirasala, ...
Journal of Cell Biology 204 (5), 669-682, 2014
|Matrix elasticity regulates lamin-A, C phosphorylation and turnover with feedback to actomyosin|
A Buxboim, J Swift, J Irianto, KR Spinler, PCDP Dingal, A Athirasala, ...
Current Biology 24 (16), 1909-1917, 2014
|Mechanosensing by the nucleus: From pathways to scaling relationships|
S Cho, J Irianto, DE Discher
Journal of Cell Biology 216 (2), 305-315, 2017
|DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration|
J Irianto, Y Xia, CR Pfeifer, A Athirasala, J Ji, C Alvey, M Tewari, ...
Current Biology 27 (2), 210-223, 2017
|Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest|
S Cho, M Vashisth, A Abbas, S Majkut, K Vogel, Y Xia, IL Ivanovska, ...
Developmental cell 49 (6), 920-935. e5, 2019
|Nuclear constriction segregates mobile nuclear proteins away from chromatin|
J Irianto, CR Pfeifer, RR Bennett, Y Xia, IL Ivanovska, AJ Liu, ...
Molecular biology of the cell 27 (25), 4011-4020, 2016
|Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment|
J Chen, J Irianto, S Inamdar, P Pravincumar, DA Lee, DL Bader, ...
Biophysical journal 103 (6), 1188-1197, 2012
|Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes|
J Irianto, J Swift, RP Martins, GD McPhail, MM Knight, DE Discher, DA Lee
Biophysical journal 104 (4), 759-769, 2013
|Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes|
A Buxboim, J Irianto, J Swift, A Athirasala, JW Shin, F Rehfeldt, ...
Molecular biology of the cell 28 (23), 3333-3348, 2017
|Nuclear lamins in cancer|
J Irianto, CR Pfeifer, IL Ivanovska, J Swift, DE Discher
Cellular and molecular bioengineering 9 (2), 258-267, 2016
|SIRPA-inhibited, marrow-derived macrophages engorge, accumulate, and differentiate in antibody-targeted regression of solid tumors|
CM Alvey, KR Spinler, J Irianto, CR Pfeifer, B Hayes, Y Xia, S Cho, ...
Current Biology 27 (14), 2065-2077. e6, 2017
|Nuclear rupture at sites of high curvature compromises retention of DNA repair factors|
Y Xia, IL Ivanovska, K Zhu, L Smith, J Irianto, CR Pfeifer, CM Alvey, J Ji, ...
Journal of Cell Biology 217 (11), 3796-3808, 2018
|Constricted migration increases DNA damage and independently represses cell cycle|
CR Pfeifer, Y Xia, K Zhu, D Liu, J Irianto, VMM García, LMS Millán, ...
Molecular biology of the cell 29 (16), 1948-1962, 2018
|Genome variation across cancers scales with tissue stiffness–An invasion-mutation mechanism and implications for immune cell infiltration|
CR Pfeifer, CM Alvey, J Irianto, DE Discher
Current opinion in systems biology 2, 103-114, 2017
|SnapShot: mechanosensing matrix|
J Irianto, CR Pfeifer, Y Xia, DE Discher
Cell 165 (7), 1820, 2016
|Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage|
J Irianto, G Ramaswamy, R Serra, MM Knight
Journal of biomechanics 47 (2), 579-582, 2014
|As a nucleus enters a small pore, chromatin stretches and maintains integrity, even with DNA breaks|
J Irianto, Y Xia, CR Pfeifer, RA Greenberg, DE Discher
Biophysical journal 112 (3), 446-449, 2017
|Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle|
Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ...
Journal of Cell Biology 218 (8), 2545-2563, 2019
|Elastic-fluid model for DNA damage and mutation from nuclear fluid segregation due to cell migration|
RR Bennett, CR Pfeifer, J Irianto, Y Xia, DE Discher, AJ Liu
Biophysical journal 112 (11), 2271-2279, 2017