David Vocadlo
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Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
DJ Vocadlo, GJ Davies, R Laine, SG Withers
Nature 412 (6849), 835, 2001
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ...
Nature chemical biology 4 (8), 483, 2008
Current developments in fluorescent PET (photoinduced electron transfer) sensors and switches
B Daly, J Ling, AP De Silva
Chemical Society Reviews 44 (13), 4203-4211, 2015
A chemical approach for identifying O-GlcNAc-modified proteins in cells
DJ Vocadlo, HC Hang, EJ Kim, JA Hanover, CR Bertozzi
Proceedings of the National Academy of Sciences 100 (16), 9116-9121, 2003
O-GlcNAcase uses substrate-assisted catalysis Kinetic analysis and development of highly selective mechanism-inspired inhibitors
MS Macauley, GE Whitworth, AW Debowski, D Chin, DJ Vocadlo
Journal of Biological Chemistry 280 (27), 25313-25322, 2005
Mechanistic insights into glycosidase chemistry
DJ Vocadlo, GJ Davies
Current opinion in chemical biology 12 (5), 539-555, 2008
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
SA Yuzwa, X Shan, MS Macauley, T Clark, Y Skorobogatko, K Vosseller, ...
Nature chemical biology 8 (4), 393, 2012
Crystallographic evidence for substrate-assisted catalysis in a bacterial β-hexosaminidase
BL Mark, DJ Vocadlo, S Knapp, BL Triggs-Raine, SG Withers, ...
Journal of Biological Chemistry 276 (13), 10330-10337, 2001
NAG-thiazoline, an N-acetyl-β-hexosaminidase inhibitor that implicates acetamido participation
S Knapp, D Vocadlo, Z Gao, B Kirk, J Lou, SG Withers
Journal of the American Chemical Society 118 (28), 6804-6805, 1996
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells
TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng, DJ Vocadlo
Nature chemical biology 7 (3), 174, 2011
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
RJ Dennis, EJ Taylor, MS Macauley, KA Stubbs, JP Turkenburg, SJ Hart, ...
Nature structural & molecular biology 13 (4), 365-371, 2006
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)
DAR Sinclair, M Syrzycka, MS Macauley, T Rastgardani, I Komljenovic, ...
Proceedings of the National Academy of Sciences 106 (32), 13427-13432, 2009
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway
CM Ferrer, TP Lynch, VL Sodi, JN Falcone, LP Schwab, DL Peacock, ...
Molecular cell 54 (5), 820-831, 2014
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells
Z Ma, DJ Vocadlo, K Vosseller
Journal of Biological Chemistry 288 (21), 15121-15130, 2013
Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology
TM Gloster, DJ Vocadlo
Nature chemical biology 8 (8), 683, 2012
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
GE Whitworth, MS Macauley, KA Stubbs, RJ Dennis, EJ Taylor, GJ Davies, ...
Journal of the American Chemical Society 129 (3), 635-644, 2007
The emerging link between O-GlcNAc and Alzheimer disease
Y Zhu, X Shan, SA Yuzwa, DJ Vocadlo
Journal of Biological Chemistry 289 (50), 34472-34481, 2014
A strategy for functional proteomic analysis of glycosidase activity from cell lysates
DJ Vocadlo, CR Bertozzi
Angewandte Chemie International Edition 43 (40), 5338-5342, 2004
Aspartate 313 in the Streptomyces plicatushexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition …
SJ Williams, BL Mark, DJ Vocadlo, MNG James, SG Withers
Journal of Biological Chemistry 277 (42), 40055-40065, 2002
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
SA Yuzwa, DJ Vocadlo
Chemical Society Reviews 43 (19), 6839-6858, 2014
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