Subverting hedgehog protein autoprocessing by chemical induction of paracatalysis CJ Smith, AG Wagner, RT Stagnitta, Z Xu, JL Pezzullo, JL Giner, J Xie, ... Biochemistry 59 (6), 736-741, 2020 | 13 | 2020 |
Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism DA Ciulla, AG Wagner, X Liu, CL Cooper, MT Jorgensen, C Wang, ... Chemical Communications 55 (12), 1829-1832, 2019 | 12 | 2019 |
General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing J Zhao, DA Ciulla, J Xie, AG Wagner, DA Castillo, AS Zwarycz, Z Lin, ... Journal of the American Chemical Society 141 (46), 18380-18384, 2019 | 11 | 2019 |
Nanomolar, noncovalent antagonism of hedgehog cholesterolysis: exception to the “irreversibility rule” for protein autoprocessing inhibition AG Wagner, RT Stagnitta, Z Xu, JL Pezzullo, N Kandel, JL Giner, ... Biochemistry 61 (11), 1022-1028, 2021 | 8 | 2021 |
Specificity Distorted: Chemical Induction of Biological Paracatalysis BP Callahan, DA Ciulla, AG Wagner, Z Xu, X Zhang Biochemistry 59 (38), 3517-3522, 2020 | 5 | 2020 |
Discovery of the first tight‐binding reversible antagonists of Hedgehog protein autoprocessing AG Wagner, RT Stagnitta, Z Xu, JL Pezzullo, N Kandel, JL Giner, ... The FASEB Journal 36, 2022 | | 2022 |
Characterization of the Drosophila melanogaster Hedgehog C-Terminal Autoprocessing Domain: Activation, Inhibition, and Mutagenesis AG Wagner State University of New York at Binghamton, 2022 | | 2022 |
Small molecule activators of hedgehog protein autoprocessing that tilt reaction outcome toward parasitic hydrolysis C Smith, L Cruceta, A Wagner, D Ciulla, J Zhao, C Wang, B Callahan ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |