|Chaperoning signaling pathways: molecular chaperones as stress-sensingheat shock'proteins|
EAA Nollen, RI Morimoto
Journal of cell science 115 (14), 2809-2816, 2002
|Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation|
EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ...
Proceedings of the National Academy of Sciences 101 (17), 6403-6408, 2004
|C. elegans model identifies genetic modifiers of α-synuclein inclusion formation during aging|
TJ Van Ham, KL Thijssen, R Breitling, RMW Hofstra, RHA Plasterk, ...
PLoS Genet 4 (3), e1000027, 2008
|Polyglutamine protein aggregates are dynamic|
S Kim, EAA Nollen, K Kitagawa, VP Bindokas, RI Morimoto
Nature cell biology 4 (10), 826-831, 2002
|In vivo chaperone activity of heat shock protein 70 and thermotolerance|
EAA Nollen, JF Brunsting, H Roelofsen, LA Weber, HH Kampinga
Molecular and cellular biology 19 (3), 2069-2079, 1999
|Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity|
EAA Nollen, JF Brunsting, J Song, HH Kampinga, RI Morimoto
Molecular and Cellular Biology 20 (3), 1083-1088, 2000
|Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation|
AT Van Der Goot, W Zhu, RP Vázquez-Manrique, RI Seinstra, K Dettmer, ...
Proceedings of the National Academy of Sciences 109 (37), 14912-14917, 2012
|Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1|
EAA Nollen, AE Kabakov, JF Brunsting, B Kanon, J Höhfeld, ...
Journal of Biological Chemistry 276 (7), 4677-4682, 2001
|A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity|
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
|An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease|
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
|Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection|
EAA Nollen, FA Salomons, JF Brunsting, JJL van der Want, OCM Sibon, ...
Proceedings of the National Academy of Sciences 98 (21), 12038-12043, 2001
|Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity|
TJ van Ham, MA Holmberg, AT van der Goot, E Teuling, ...
Cell 142 (4), 601-612, 2010
|Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip|
C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ...
The EMBO journal 28 (23), 3758-3770, 2009
|Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond|
M Platten, EAA Nollen, UF Röhrig, F Fallarino, CA Opitz
Nature reviews Drug discovery 18 (5), 379-401, 2019
|Tryptophan metabolism: entering the field of aging and age-related pathologies|
AT Van der Goot, EAA Nollen
Trends in molecular medicine 19 (6), 336-344, 2013
|Neurodegenerative diseases: lessons from genome‐wide screens in small model organisms|
TJ van Ham, R Breitling, MA Swertz, EAA Nollen
EMBO molecular medicine 1 (8‐9), 360-370, 2009
|A FRET sensor for non-invasive imaging of amyloid formation in vivo|
GSK Schierle, CW Bertoncini, FTS Chan, AT Van Der Goot, S Schwedler, ...
Chemphyschem: a European journal of chemical physics and physical chemistry …, 2011
|Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality|
G van Haaften, NL Vastenhouw, EAA Nollen, RHA Plasterk, M Tijsterman
Proceedings of the National Academy of Sciences 101 (35), 12992-12996, 2004
|Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of α-synuclein aggregation|
TJ van Ham, A Esposito, JR Kumita, STD Hsu, GSK Schierle, CF Kaminski, ...
Journal of molecular biology 395 (3), 627-642, 2010
|Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated …|
K Siudeja, B Srinivasan, L Xu, A Rana, J de Jong, EAA Nollen, ...
EMBO molecular medicine 3 (12), 755-766, 2011