Kuang Shen
Kuang Shen
Assistant Professor, UMass Medical School
Verified email at umassmed.edu
Cited by
Cited by
Sestrin2 is a leucine sensor for the mTORC1 pathway
RL Wolfson, L Chantranupong, RA Saxton, K Shen, SM Scaria, JR Cantor, ...
Science 351 (6268), 43-48, 2016
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ...
Science 347 (6218), 188-194, 2015
The CASTOR proteins are arginine sensors for the mTORC1 pathway
L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ...
Cell 165 (1), 153-164, 2016
What are the pKa values of C–H bonds in aromatic heterocyclic compounds in DMSO?
K Shen, Y Fu, JN Li, L Liu, QX Guo
Tetrahedron 63 (7), 1568-1576, 2007
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity
BC Grabiner, V Nardi, K Birsoy, R Possemato, K Shen, S Sinha, A Jordan, ...
Cancer discovery 4 (5), 554-563, 2014
Signal recognition particle: an essential protein-targeting machine
D Akopian, K Shen, X Zhang, S Shan
Annual review of biochemistry 82, 693-721, 2013
Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant
L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch, TP Nyalile, Y Wang, ...
Cell 183 (3), 739-751. e8, 2020
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
RL Wolfson, L Chantranupong, GA Wyant, X Gu, JM Orozco, K Shen, ...
Nature 543 (7645), 438-442, 2017
The crystal structure of the signal recognition particle in complex with its receptor
SF Ataide, N Schmitz, K Shen, A Ke, S Shan, JA Doudna, N Ban
Science 331 (6019), 881-886, 2011
Activated GTPase movement on an RNA scaffold drives co-translational protein targeting
K Shen, S Arslan, D Akopian, T Ha, S Shan
Nature 492 (7428), 271-275, 2012
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
K Shen, RK Huang, EJ Brignole, KJ Condon, ML Valenstein, ...
Nature 556 (7699), 64-69, 2018
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
K Shen, DM Sabatini
Proceedings of the National Academy of Sciences 115 (38), 9545-9550, 2018
ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit
P Jaru-Ampornpan, K Shen, VQ Lam, M Ali, S Doniach, TZ Jia, S Shan
Nature structural & molecular biology 17 (6), 696, 2010
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
JM Heo, A Ordureau, S Swarup, JA Paulo, K Shen, DM Sabatini, ...
Science advances 4 (11), eaav0443, 2018
SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain
L Yurkovetskiy, KE Pascal, C Tomkins-Tinch, T Nyalile, Y Wang, A Baum, ...
BioRxiv, 2020
Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting
K Shen, S Shan
Proceedings of the National Academy of Sciences 107 (17), 7698-7703, 2010
SecYEG activates GTPases to drive the completion of cotranslational protein targeting
D Akopian, K Dalal, K Shen, F Duong, S Shan
Journal of Cell Biology 200 (4), 397-405, 2013
The structural basis of FtsY recruitment and GTPase activation by SRP RNA
F Voigts-Hoffmann, N Schmitz, K Shen, S Shan, SF Ataide, N Ban
Molecular cell 52 (5), 643-654, 2013
Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability
K Shen, A Choe, DM Sabatini
Molecular cell 68 (3), 552-565. e8, 2017
Cryo-EM structure of the human FLCN-FNIP2-Rag-ragulator complex
K Shen, KB Rogala, HT Chou, RK Huang, Z Yu, DM Sabatini
Cell 179 (6), 1319-1329. e8, 2019
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