| Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates D Martindale, A Hackam, A Wieczorek, L Ellerby, C Wellington, ... Nature genetics 18 (2), 150-154, 1998 | 581 | 1998 |
| Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ... Journal of Neuroscience 22 (18), 7862-7872, 2002 | 499 | 2002 |
| Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells CL Wellington, L Ellerby, J Savill, S Roy, B Leavitt, E Cattaneo, A Hackam, ... Journal of Biological Chemistry 275 (26), 19831-19838, 2000 | 473 | 2000 |
| The influence of huntingtin protein size on nuclear localization and cellular toxicity AS Hackam, R Singaraja, CL Wellington, M Metzler, K McCutcheon, ... The Journal of cell biology 141 (5), 1097-1105, 1998 | 427 | 1998 |
| Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi FG Gervais, R Singaraja, S Xanthoudakis, CA Gutekunst, BR Leavitt, ... Nature cell biology 4 (2), 95-105, 2002 | 418 | 2002 |
| Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins K Huang, A Yanai, R Kang, P Arstikaitis, M Metzler, A Mullard, B Haigh, ... Neuron 44 (6), 977-986, 2004 | 383 | 2004 |
| Increased ABCA1 activity protects against atherosclerosis C Fievet, G Castro, ER James, N Hennuyer, SM Clee, N Bissada, ... The Journal of clinical investigation 110 (1), 35-42, 2002 | 375 | 2002 |
| Efflux and Atherosclerosis: The Clinical and Biochemical Impact of Variations in the ABCA1 Gene RR Singaraja, LR Brunham, H Visscher, JJP Kastelein, MR Hayden Arteriosclerosis, thrombosis, and vascular biology 23 (8), 1322-1332, 2003 | 357 | 2003 |
| ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation CL Wellington, EKY Walker, A Suarez, A Kwok, N Bissada, YZ Yang, ... Laboratory investigation 82 (3), 273-283, 2002 | 340 | 2002 |
| Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo BR Leavitt, JA Guttman, JG Hodgson, GH Kimel, AW Vogl, MR Hayden The American Journal of Human Genetics 68 (2), 313-324, 2001 | 309 | 2001 |
| HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis RR Singaraja, S Hadano, M Metzler, S Givan, CL Wellington, S Warby, ... Human molecular genetics 11 (23), 2815-2828, 2002 | 271 | 2002 |
| Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice M Van Eck, RR Singaraja, D Ye, RB Hildebrand, ER James, MR Hayden, ... Arteriosclerosis, thrombosis, and vascular biology 26 (4), 929-934, 2006 | 248 | 2006 |
| Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor … V Bocher, ER James, SM Clee, LH Zhang, BR Leavitt, B Tan, ... Journal of biological chemistry 276 (36), 33969-33979, 2001 | 227 | 2001 |
| Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo SC Warby, EY Chan, M Metzler, L Gan, RR Singaraja, SF Crocker, ... Human molecular genetics 14 (11), 1569-1577, 2005 | 191 | 2005 |
| Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis LR Brunham, RR Singaraja, MR Hayden Annu. Rev. Nutr. 26, 105-129, 2006 | 188 | 2006 |
| Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain AS Hackam, AS Yassa, M Metzler, CA Gutekunst, L Gan, S Warby, ... Journal of Biological Chemistry 275 (52), 41299-41308, 2000 | 177 | 2000 |
| Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity K Huang, S Sanders, P Orban, T Cijsouw, P Arstikaitis, A Yanai, ... The FASEB Journal 23 (8), 2605, 2009 | 175 | 2009 |
| ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels KY Zwarts, SM Clee, AH Zwinderman, JC Engert, R Singaraja, O Loubser, ... Clinical genetics 61 (2), 115-125, 2002 | 169 | 2002 |
| Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ... Human molecular genetics 17 (15), 2390-2404, 2008 | 162 | 2008 |
| Accurate Prediction of the Functional Significance of Single Nucleotide Polymorphisms and Mutations in the ABCA1 Gene LR Brunham, RR Singaraja, TD Pape, A Kejariwal, PD Thomas, ... PLoS genetics 1 (6), e83, 2005 | 160 | 2005 |
