| Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations PJ Pollard, JJ Briere, NA Alam, J Barwell, E Barclay, NC Wortham, T Hunt, ... Human molecular genetics 14 (15), 2231-2239, 2005 | 1014 | 2005 |
| Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency NA Alam, AJ Rowan, NC Wortham, PJ Pollard, M Mitchell, JP Tyrer, ... Human molecular genetics 12 (11), 1241-1252, 2003 | 371 | 2003 |
| The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase P Pollard, N Wortham, I Tomlinson Annals of medicine 35 (8), 634-635, 2003 | 179 | 2003 |
| Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations LG Carvajal-Carmona, NA Alam, PJ Pollard, AM Jones, E Barclay, ... The Journal of Clinical Endocrinology & Metabolism 91 (8), 3071-3075, 2006 | 138 | 2006 |
| The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer NC Wortham, E Ahamed, SM Nicol, RS Thomas, M Periyasamy, J Jiang, ... Oncogene 28 (46), 4053-4064, 2009 | 134 | 2009 |
| Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome P Pollard, N Wortham, E Barclay, A Alam, G Elia, S Manek, R Poulsom, ... The Journal of Pathology: A Journal of the Pathological Society of Great …, 2005 | 129 | 2005 |
| CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability Z Kemp, A Rowan, W Chambers, N Wortham, S Halford, O Sieber, ... Cancer research 65 (24), 11361-11366, 2005 | 117 | 2005 |
| A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH R Roylance, P Gorman, T Papior, YL Wan, M Ives, JE Watson, C Collins, ... Oncogene 25 (49), 6544-6553, 2006 | 89 | 2006 |
| Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes R Liu, HDW Van Der Lei, X Wang, NC Wortham, H Tang, CGM van Berkel, ... Human mutation 32 (9), 1036-1045, 2011 | 81 | 2011 |
| Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation NC Wortham, M Martinez, Y Gordiyenko, CV Robinson, CG Proud The FASEB Journal 28 (5), 2225-2237, 2014 | 78 | 2014 |
| eIF2B: recent structural and functional insights into a key regulator of translation NC Wortham, CG Proud Biochemical Society Transactions 43 (6), 1234-1240, 2015 | 64 | 2015 |
| Dercum's disease NC Wortham, IPM Tomlinson SKINmed: Dermatology for the Clinician 4 (3), 157-162, 2005 | 52 | 2005 |
| 7q deletion mapping and expression profiling in uterine fibroids S Vanharanta, NC Wortham, P Laiho, J Sjöberg, K Aittomäki, J Arola, ... Oncogene 24 (43), 6545-6554, 2005 | 48 | 2005 |
| Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5 T Matsukawa, X Wang, R Liu, NC Wortham, Y Onuki, A Kubota, A Hida, ... Neurogenetics 12, 259-261, 2011 | 43 | 2011 |
| Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex X Wang, NC Wortham, R Liu, CG Proud Journal of Biological Chemistry 287 (11), 8263-8274, 2012 | 29 | 2012 |
| Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease NC Wortham, CG Proud BMC medical genetics 16, 1-8, 2015 | 20 | 2015 |
| Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits NC Wortham, JD Stewart, S Harris, MJ Coldwell, CG Proud Biochemical Journal 473 (5), 571-580, 2016 | 19 | 2016 |
| Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma NC Wortham, NA Alam, E Barclay, PJ Pollard, BE Wagner, S Manek, ... Fertility and sterility 86 (4), 961-971, 2006 | 17 | 2006 |
| Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling‐path microarray CGH and mutation analysis of known genes in this region S Vanharanta, NC Wortham, C Langford, M El‐Bahrawy, Z Van Der Spuy, ... Genes, Chromosomes and Cancer 46 (5), 451-458, 2007 | 15 | 2007 |
| Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia JN Murdoch, K Doudney, D Gerrelli, N Wortham, C Paternotte, P Stanier, ... Molecular and Cellular Neuroscience 22 (1), 62-74, 2003 | 13 | 2003 |
