Kelly Paige Brock
Kelly Paige Brock
Kernal Biologics
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Cited by
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Disease variant prediction with deep generative models of evolutionary data
J Frazer, P Notin, M Dias, A Gomez, JK Min, K Brock, Y Gal, DS Marks
Nature 599 (7883), 91-95, 2021
The EVcouplings Python framework for coevolutionary sequence analysis
TA Hopf, AG Green, B Schubert, S Mersmann, CPI Schärfe, JB Ingraham, ...
Bioinformatics 35 (9), 1582-1584, 2019
Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
X Sui, H Arlt, KP Brock, ZW Lai, F DiMaio, DS Marks, M Liao, RV Farese Jr, ...
Journal of Cell Biology 217 (12), 4080-4091, 2018
Inferring protein 3D structure from deep mutation scans
NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ...
Nature genetics 51 (7), 1170-1176, 2019
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis
M Sjodt, K Brock, G Dobihal, PDA Rohs, AG Green, TA Hopf, AJ Meeske, ...
Nature 556 (7699), 118-121, 2018
Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex
M Sjodt, PDA Rohs, MSA Gilman, SC Erlandson, S Zheng, AG Green, ...
Nature microbiology 5 (6), 813-820, 2020
Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences
AG Green, H Elhabashy, KP Brock, R Maddamsetti, O Kohlbacher, ...
Nature communications 12 (1), 1396, 2021
Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli
S Zheng, LT Sham, FA Rubino, KP Brock, WP Robins, JJ Mekalanos, ...
Proceedings of the National Academy of Sciences 115 (26), 6709-6714, 2018
Optimization of electrostatic interactions in protein-protein complexes
K Brock, K Talley, K Coley, P Kundrotas, E Alexov
Biophysical journal 93 (10), 3340-3352, 2007
Protein structure from experimental evolution
MA Stiffler, FJ Poelwijk, KP Brock, RR Stein, A Riesselman, J Teyra, ...
Cell Systems 10 (1), 15-24. e5, 2020
PDBe-KB: collaboratively defining the biological context of structural data
Nucleic acids research 50 (D1), D534-D542, 2022
Dormant spores sense amino acids through the B subunits of their germination receptors
L Artzi, A Alon, KP Brock, AG Green, A Tam, FH Ramírez-Guadiana, ...
Nature Communications 12 (1), 6842, 2021
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination
Y Gao, RDC Barajas-Ornelas, JD Amon, FH Ramírez-Guadiana, A Alon, ...
Genes & Development 36 (9-10), 634-646, 2022
Protein structure prediction assisted with sparse NMR data in CASP13
D Sala, YJ Huang, CA Cole, DA Snyder, G Liu, Y Ishida, GVT Swapna, ...
Proteins: Structure, Function, and Bioinformatics 87 (12), 1315-1332, 2019
Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning
J Frazer, P Notin, M Dias, A Gomez, K Brock, Y Gal, DS Marks
bioRxiv, 2020.12. 21.423785, 2020
Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol 5: 813–820
M Sjodt, PDA Rohs, MSA Gilman, SC Erlandson, S Zheng, AG Green, ...
Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis
FH Ramírez-Guadiana, CDA Rodrigues, KA Marquis, N Campo, ...
PLoS Genetics 14 (11), e1007753, 2018
Bacterial spore germination receptors are nutrient-gated ion channels
Y Gao, JD Amon, L Artzi, FH Ramírez-Guadiana, KP Brock, JC Cofsky, ...
Science 380 (6643), 387-391, 2023
Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices
N Akyuz, KD Karavitaki, B Pan, PI Tamvakologos, KP Brock, Y Li, ...
Science Advances 8 (28), eabo1126, 2022
Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells
MT Veling, DT Nguyen, NN Thadani, ME Oster, NJ Rollins, KP Brock, ...
ACS synthetic biology 11 (3), 1292-1302, 2022
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