Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance C Dogovski, SC Xie, G Burgio, J Bridgford, S Mok, JM McCaw, ... PLoS biology 13 (4), e1002132, 2015 | 340 | 2015 |
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ... Nature communications 9 (1), 3801, 2018 | 248 | 2018 |
Structure- and function-based design of Plasmodium-selective proteasome inhibitors H Li, AJ O’Donoghue, WA van der Linden, SC Xie, E Yoo, IT Foe, L Tilley, ... Nature 530 (7589), 233-236, 2016 | 242 | 2016 |
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin N Klonis, SC Xie, JM McCaw, MP Crespo-Ortiz, SG Zaloumis, JA Simpson, ... Proceedings of the National Academy of Sciences 110 (13), 5157-5162, 2013 | 222 | 2013 |
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ... Cell reports 29 (9), 2917-2928. e5, 2019 | 129 | 2019 |
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, ... Journal of cell science 129 (2), 406-416, 2016 | 128 | 2016 |
K13, the cytostome, and artemisinin resistance SC Xie, SA Ralph, L Tilley Trends in parasitology 36 (6), 533-544, 2020 | 72 | 2020 |
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome SC Xie, DL Gillett, NJ Spillman, C Tsu, MR Luth, S Ottilie, S Duffy, ... Journal of medicinal chemistry 61 (22), 10053-10066, 2018 | 61 | 2018 |
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum … T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ... Antimicrobial agents and chemotherapy 60 (8), 4501-4510, 2016 | 60 | 2016 |
The proteasome as a target for protozoan parasites SC Xie, LR Dick, A Gould, S Brand, L Tilley Expert opinion on therapeutic targets 23 (11), 903-914, 2019 | 36 | 2019 |
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ... Nature microbiology 4 (11), 1990-2000, 2019 | 35 | 2019 |
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy SC Xie, RD Metcalfe, E Dunn, CJ Morton, SC Huang, T Puhalovich, Y Du, ... Science 376 (6597), 1074-1079, 2022 | 27 | 2022 |
Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins SC Xie, C Dogovski, S Kenny, L Tilley, N Klonis International journal for parasitology 44 (12), 893-899, 2014 | 24 | 2014 |
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome SC Xie, RD Metcalfe, H Mizutani, T Puhalovich, E Hanssen, CJ Morton, ... Proceedings of the National Academy of Sciences 118 (39), e2107213118, 2021 | 20 | 2021 |
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum P Cao, N Klonis, S Zaloumis, C Dogovski, SC Xie, S Saralamba, LJ White, ... Antimicrobial agents and chemotherapy 61 (12), 10.1128/aac. 00618-17, 2017 | 13 | 2017 |
Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development SC Xie, MDW Griffin, EA Winzeler, L Ribas de Pouplana, L Tilley Annual Review of Microbiology 77, 111-129, 2023 | 6 | 2023 |
High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials L Mata-Cantero, SC Xie, M García, J Coyle, R Fernandez, AC Cabrera, ... ACS Infectious Diseases 7 (6), 1818-1832, 2021 | 3 | 2021 |
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase SC Xie, Y Wang, CJ Morton, RD Metcalfe, C Dogovski, CFA Pasaje, ... Nature Communications 15 (1), 937, 2024 | | 2024 |
Reaction hijacking ATP-activated enzymes as a strategy to develop new anti-infectives S Xie, R Metcalfe, E Dunn, C Morton, S Huang, S Wittlin, E Winzeler, ... FEBS OPEN BIO 12, 23-23, 2022 | | 2022 |
CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY S Xie, M Griffin, R Metcalfe, E Hanssen, T Yang, D Gilley, A Leis, C Morton, ... PROTEIN SCIENCE 28, 55-56, 2019 | | 2019 |