| mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease KS Abd-Elrahman, A Hamilton, SR Hutchinson, F Liu, RC Russell, ... Science signaling 10 (510), eaan6387, 2017 | 80 | 2017 |
| Stromatoxin‐sensitive, heteromultimeric Kv2. 1/Kv9. 3 channels contribute to myogenic control of cerebral arterial diameter XZ Zhong, KS Abd‐Elrahman, CH Liao, AF El‐Yazbi, EJ Walsh, MP Walsh, ... The Journal of physiology 588 (22), 4519-4537, 2010 | 68 | 2010 |
| Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner KS Abd-Elrahman, A Albaker, JM de Souza, FM Ribeiro, ... Science signaling 13 (662), eabd2494, 2020 | 61 | 2020 |
| Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice KS Abd-Elrahman, SSG Ferguson Molecular brain 12 (1), 35, 2019 | 56 | 2019 |
| Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models KS Abd-Elrahman, A Hamilton, M Vasefi, SSG Ferguson Molecular Brain 11, 1-8, 2018 | 52 | 2018 |
| Pioglitazone abrogates cyclosporine-evoked hypertension via rectifying abnormalities in vascular endothelial function MM El-Mas, HM El-Gowelli, KS Abd-Elrahman, EI Saad, AGA Abdel-Galil, ... Biochemical pharmacology 81 (4), 526-533, 2011 | 46 | 2011 |
| Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease KS Abd-Elrahman, SSG Ferguson Annual Review of Pharmacology and Toxicology 62, 235-254, 2022 | 40 | 2022 |
| mGluR5 contribution to neuropathology in Alzheimer mice is disease stage-dependent KS Abd-Elrahman, A Hamilton, A Albaker, SSG Ferguson ACS pharmacology & translational science 3 (2), 334-344, 2020 | 40 | 2020 |
| PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization AF El-Yazbi, KS Abd-Elrahman, A Moreno-Dominguez Biochemical pharmacology 95 (4), 263-278, 2015 | 39 | 2015 |
| Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs MAW Elkhatib, A Mroueh, RW Rafeh, F Sleiman, H Fouad, EI Saad, ... Translational Research 214, 121-143, 2019 | 33 | 2019 |
| Podocyte NADPH oxidase 5 promotes renal inflammation regulated by the toll-like receptor pathway CE Holterman, NC Boisvert, JF Thibodeau, E Kamto, M Novakovic, ... Antioxidants & redox signaling 30 (15), 1817-1830, 2019 | 32 | 2019 |
| ROK and arteriolar myogenic tone generation: molecular evidence in health and disease AF El-Yazbi, KS Abd-Elrahman Frontiers in pharmacology 8, 245203, 2017 | 32 | 2017 |
| mGluR5 allosteric modulation promotes neurorecovery in a 6-OHDA-toxicant model of Parkinson’s disease K Farmer, KS Abd-Elrahman, A Derksen, EM Rowe, AM Thompson, ... Molecular Neurobiology 57, 1418-1431, 2020 | 31 | 2020 |
| Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes KS Abd-Elrahman, MP Walsh, WC Cole Canadian Journal of Physiology and Pharmacology 93 (3), 177-184, 2015 | 25 | 2015 |
| Abnormal myosin phosphatase targeting subunit 1 phosphorylation and actin polymerization contribute to impaired myogenic regulation of cerebral arterial diameter in the type 2 … KS Abd-Elrahman, O Colinas, EJ Walsh, HL Zhu, CM Campbell, ... Journal of Cerebral Blood Flow & Metabolism 37 (1), 227-240, 2017 | 22 | 2017 |
| mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease JM de Souza, KS Abd-Elrahman, FM Ribeiro, SSG Ferguson Molecular brain 13, 1-15, 2020 | 21 | 2020 |
| A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice KS Abd‐Elrahman, S Sarasija, TLL Colson, SSG Ferguson British Journal of Pharmacology 179 (8), 1769-1783, 2022 | 20* | 2022 |
| Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases SH Li, KS Abd-Elrahman, SSG Ferguson Pharmacology & Therapeutics 239, 108275, 2022 | 19 | 2022 |
| Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior KS Ibrahim, KS Abd-Elrahman, S El Mestikawy, SSG Ferguson Molecular pharmacology 98 (4), 314-327, 2020 | 18 | 2020 |
| Vascular smooth muscle-specific EP4 receptor deletion in mice exacerbates angiotensin II-induced renal injury JF Thibodeau, CE Holterman, Y He, A Carter, GO Cron, NC Boisvert, ... Antioxidants & redox signaling 25 (12), 642-656, 2016 | 18 | 2016 |
Stephen SG FergusonUniversity of Ottawa Brain and Mind Institute, Department of Cellular MedicineVerified email at uottawa.ca
