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Khaled S. Abd-Elrahman
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mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease
KS Abd-Elrahman, A Hamilton, SR Hutchinson, F Liu, RC Russell, ...
Science signaling 10 (510), eaan6387, 2017
812017
Stromatoxin‐sensitive, heteromultimeric Kv2. 1/Kv9. 3 channels contribute to myogenic control of cerebral arterial diameter
XZ Zhong, KS Abd‐Elrahman, CH Liao, AF El‐Yazbi, EJ Walsh, MP Walsh, ...
The Journal of physiology 588 (22), 4519-4537, 2010
682010
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner
KS Abd-Elrahman, A Albaker, JM de Souza, FM Ribeiro, ...
Science signaling 13 (662), eabd2494, 2020
642020
Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
KS Abd-Elrahman, SSG Ferguson
Molecular brain 12 (1), 35, 2019
572019
Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
KS Abd-Elrahman, A Hamilton, M Vasefi, SSG Ferguson
Molecular Brain 11, 1-8, 2018
532018
Pioglitazone abrogates cyclosporine-evoked hypertension via rectifying abnormalities in vascular endothelial function
MM El-Mas, HM El-Gowelli, KS Abd-Elrahman, EI Saad, AGA Abdel-Galil, ...
Biochemical pharmacology 81 (4), 526-533, 2011
472011
Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease
KS Abd-Elrahman, SSG Ferguson
Annual Review of Pharmacology and Toxicology 62, 235-254, 2022
442022
mGluR5 contribution to neuropathology in Alzheimer mice is disease stage-dependent
KS Abd-Elrahman, A Hamilton, A Albaker, SSG Ferguson
ACS pharmacology & translational science 3 (2), 334-344, 2020
412020
PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization
AF El-Yazbi, KS Abd-Elrahman, A Moreno-Dominguez
Biochemical pharmacology 95 (4), 263-278, 2015
392015
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
MAW Elkhatib, A Mroueh, RW Rafeh, F Sleiman, H Fouad, EI Saad, ...
Translational Research 214, 121-143, 2019
332019
ROK and arteriolar myogenic tone generation: molecular evidence in health and disease
AF El-Yazbi, KS Abd-Elrahman
Frontiers in pharmacology 8, 245203, 2017
322017
mGluR5 allosteric modulation promotes neurorecovery in a 6-OHDA-toxicant model of Parkinson’s disease
K Farmer, KS Abd-Elrahman, A Derksen, EM Rowe, AM Thompson, ...
Molecular Neurobiology 57, 1418-1431, 2020
312020
Podocyte NADPH oxidase 5 promotes renal inflammation regulated by the toll-like receptor pathway
CE Holterman, NC Boisvert, JF Thibodeau, E Kamto, M Novakovic, ...
Antioxidants & redox signaling 30 (15), 1817-1830, 2019
312019
Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes
KS Abd-Elrahman, MP Walsh, WC Cole
Canadian Journal of Physiology and Pharmacology 93 (3), 177-184, 2015
252015
A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice
KS Abd‐Elrahman, S Sarasija, TLL Colson, SSG Ferguson
British Journal of Pharmacology 179 (8), 1769-1783, 2022
23*2022
mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
JM de Souza, KS Abd-Elrahman, FM Ribeiro, SSG Ferguson
Molecular brain 13, 1-15, 2020
222020
Abnormal myosin phosphatase targeting subunit 1 phosphorylation and actin polymerization contribute to impaired myogenic regulation of cerebral arterial diameter in the type 2 …
KS Abd-Elrahman, O Colinas, EJ Walsh, HL Zhu, CM Campbell, ...
Journal of Cerebral Blood Flow & Metabolism 37 (1), 227-240, 2017
222017
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
SH Li, KS Abd-Elrahman, SSG Ferguson
Pharmacology & Therapeutics 239, 108275, 2022
202022
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
W Fakih, R Zeitoun, I AlZaim, AH Eid, F Kobeissy, KS Abd‐Elrahman, ...
Obesity 30 (5), 982-993, 2022
192022
Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior
KS Ibrahim, KS Abd-Elrahman, S El Mestikawy, SSG Ferguson
Molecular pharmacology 98 (4), 314-327, 2020
182020
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