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Mi Wang
Mi Wang
Verified email at med.umich.edu
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Year
A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo
L Bai, H Zhou, R Xu, Y Zhao, K Chinnaswamy, D McEachern, J Chen, ...
Cancer cell 36 (5), 498-511. e17, 2019
4202019
Discovery of ARD-69 as a highly potent proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) for the treatment of prostate cancer
X Han, C Wang, C Qin, W Xiang, E Fernandez-Salas, CY Yang, M Wang, ...
Journal of medicinal chemistry 62 (2), 941-964, 2019
3242019
Discovery of QCA570 as an exceptionally potent and efficacious proteolysis targeting chimera (PROTAC) degrader of the bromodomain and extra-terminal (BET) proteins capable of …
C Qin, Y Hu, B Zhou, E Fernandez-Salas, CY Yang, L Liu, D McEachern, ...
Journal of medicinal chemistry 61 (15), 6685-6704, 2018
2412018
Discovery of MD-224 as a first-in-class, highly potent, and efficacious proteolysis targeting chimera murine double minute 2 degrader capable of achieving complete and durable …
Y Li, J Yang, A Aguilar, D McEachern, S Przybranowski, L Liu, CY Yang, ...
Journal of medicinal chemistry 62 (2), 448-466, 2018
2402018
Discovery of ERD-308 as a highly potent proteolysis targeting chimera (PROTAC) degrader of estrogen receptor (ER)
J Hu, B Hu, M Wang, F Xu, B Miao, CY Yang, M Wang, Z Liu, DF Hayes, ...
Journal of medicinal chemistry 62 (3), 1420-1442, 2019
2222019
Discovery of highly potent and efficient PROTAC degraders of androgen receptor (AR) by employing weak binding affinity VHL E3 ligase ligands
X Han, L Zhao, W Xiang, C Qin, B Miao, T Xu, M Wang, CY Yang, ...
Journal of medicinal chemistry 62 (24), 11218-11231, 2019
1662019
Structure-based discovery of SD-36 as a potent, selective, and efficacious PROTAC degrader of STAT3 protein
H Zhou, L Bai, R Xu, Y Zhao, J Chen, D McEachern, K Chinnaswamy, ...
Journal of medicinal chemistry 62 (24), 11280-11300, 2019
1542019
Discovery of SHP2-D26 as a first, potent, and effective PROTAC degrader of SHP2 protein
M Wang, J Lu, M Wang, CY Yang, S Wang
Journal of medicinal chemistry 63 (14), 7510-7528, 2020
1132020
Formation of a nickel− methyl species in methyl-coenzyme M reductase, an enzyme catalyzing methane formation
N Yang, M Reiher, M Wang, J Harmer, EC Duin
Journal of the American Chemical Society 129 (36), 11028-11029, 2007
892007
Design of the first‐in‐class, highly potent irreversible inhibitor targeting the menin‐MLL protein–protein interaction
S Xu, A Aguilar, T Xu, K Zheng, L Huang, J Stuckey, K Chinnaswamy, ...
Angewandte Chemie 130 (6), 1617-1621, 2018
592018
High-affinity peptidomimetic inhibitors of the DCN1-UBC12 protein–protein interaction
H Zhou, W Zhou, B Zhou, L Liu, TR Chern, K Chinnaswamy, J Lu, ...
Journal of Medicinal Chemistry 61 (5), 1934-1950, 2018
542018
Structure-based discovery of CF53 as a potent and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor
Y Zhao, B Zhou, L Bai, L Liu, CY Yang, JL Meagher, JA Stuckey, ...
Journal of medicinal chemistry 61 (14), 6110-6120, 2018
322018
Uptake of Glycerol-2-Phosphate via the ugp-Encoded Transporter in Escherichia coli K-12
K Yang, M Wang, WW Metcalf
Journal of bacteriology 191 (14), 4667-4670, 2009
322009
氯乙酰化聚苯乙烯型固相载体的制备
魏荣卿, 王强, 刘晓宁, 王迷, 欧阳平凯
离子交换与吸附 21 (4), 289-296, 2005
302005
SD-91 as a potent and selective STAT3 degrader capable of achieving complete and long-lasting tumor regression
H Zhou, L Bai, R Xu, D McEachern, K Chinnaswamy, R Li, B Wen, ...
ACS Medicinal Chemistry Letters 12 (6), 996-1004, 2021
272021
EEDi-5285: An exceptionally potent, efficacious, and orally active small-molecule inhibitor of embryonic ectoderm development
RK Rej, C Wang, J Lu, M Wang, E Petrunak, KP Zawacki, D McEachern, ...
Journal of medicinal chemistry 63 (13), 7252-7267, 2020
262020
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
A Kaneshige, L Bai, M Wang, D McEachern, JL Meagher, R Xu, Y Wang, ...
Nature Chemical Biology 19 (6), 703-711, 2023
212023
Changing the apoptosis pathway through evolutionary protein design
D Shultis, P Mitra, X Huang, J Johnson, NA Khattak, F Gray, C Piper, ...
Journal of molecular biology 431 (4), 825-841, 2019
182019
Discovery of EEDi-5273 as an exceptionally potent and orally efficacious EED inhibitor capable of achieving complete and persistent tumor regression
RK Rej, C Wang, J Lu, M Wang, E Petrunak, KP Zawacki, D McEachern, ...
Journal of medicinal chemistry 64 (19), 14540-14556, 2021
152021
Lisaftoclax (APG-2575) is a novel BCL-2 inhibitor with robust antitumor activity in preclinical models of hematologic malignancy
J Deng, A Paulus, DD Fang, A Manna, G Wang, H Wang, S Zhu, J Chen, ...
Clinical Cancer Research 28 (24), 5455-5468, 2022
142022
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