A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) H Inoue, Y Tanizawa, J Wasson, P Behn, K Kalidas, E Bernal-Mizrachi, ... Nature genetics 20 (2), 143-148, 1998 | 850 | 1998 |
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice KA Moynihan, AA Grimm, MM Plueger, E Bernal-Mizrachi, E Ford, ... Cell metabolism 2 (2), 105-117, 2005 | 802 | 2005 |
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia E Bernal-Mizrachi, W Wen, S Stahlhut, CM Welling, MA Permutt The Journal of clinical investigation 108 (11), 1631-1638, 2001 | 502 | 2001 |
Conditional gene targeting in mouse pancreatic β-cells: analysis of ectopic Cre transgene expression in the brain B Wicksteed, M Brissova, W Yan, DM Opland, JL Plank, RB Reinert, ... Diabetes 59 (12), 3090-3098, 2010 | 374 | 2010 |
β-cell failure as a complication of diabetes KJ Chang-Chen, R Mullur, E Bernal-Mizrachi Reviews in Endocrine and Metabolic Disorders 9, 329-343, 2008 | 350 | 2008 |
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells E Bernal-Mizrachi, S Fatrai, JD Johnson, M Ohsugi, K Otani, Z Han, ... The Journal of clinical investigation 114 (7), 928-936, 2004 | 304 | 2004 |
Human β-cell proliferation and intracellular signaling: driving in the dark without a road map RN Kulkarni, EB Mizrachi, AG Ocana, AF Stewart Diabetes 61 (9), 2205-2213, 2012 | 274 | 2012 |
Inhibition of Foxo1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress–induced apoptosis SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, E Bernal-Mizrachi, ... Diabetes 57 (4), 846-859, 2008 | 274 | 2008 |
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis AC Riggs, E Bernal-Mizrachi, M Ohsugi, J Wasson, S Fatrai, C Welling, ... Diabetologia 48, 2313-2321, 2005 | 268 | 2005 |
Natural history of β-cell adaptation and failure in type 2 diabetes EU Alejandro, B Gregg, M Blandino-Rosano, C Cras-Méneur, ... Molecular aspects of medicine 42, 19-41, 2015 | 261 | 2015 |
Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity S Fatrai, L Elghazi, N Balcazar, C Cras-Méneur, I Krits, H Kiyokawa, ... Diabetes 55 (2), 318-325, 2006 | 249 | 2006 |
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner L Rachdi, N Balcazar, F Osorio-Duque, L Elghazi, A Weiss, A Gould, ... Proceedings of the National Academy of Sciences 105 (27), 9250-9255, 2008 | 237 | 2008 |
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome JD Johnson, E Bernal-Mizrachi, EU Alejandro, Z Han, TB Kalynyak, H Li, ... Proceedings of the National Academy of Sciences 103 (51), 19575-19580, 2006 | 234 | 2006 |
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP-and Ras-dependent mechanisms B Hegedus, B Dasgupta, JE Shin, RJ Emnett, EK Hart-Mahon, L Elghazi, ... Cell stem cell 1 (4), 443-457, 2007 | 223 | 2007 |
Endoplasmic reticulum stress–induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase … S Srinivasan, M Ohsugi, Z Liu, S Fatrai, E Bernal-Mizrachi, MA Permutt Diabetes 54 (4), 968-975, 2005 | 212 | 2005 |
Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map E Bernal-Mizrachi, RN Kulkarni, DK Scott, F Mauvais-Jarvis, AF Stewart, ... Diabetes 63 (3), 819-831, 2014 | 203 | 2014 |
Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation ED Dean, M Li, N Prasad, SN Wisniewski, A Von Deylen, J Spaeth, ... Cell metabolism 25 (6), 1362-1373. e5, 2017 | 174 | 2017 |
Human β-cell proliferation and intracellular signaling: part 3 AF Stewart, MA Hussain, A García-Ocaña, RC Vasavada, A Bhushan, ... Diabetes 64 (6), 1872-1885, 2015 | 160 | 2015 |
Glucose promotes pancreatic islet β-cell survival through a PI 3-kinase/Akt-signaling pathway S Srinivasan, E Bernal-Mizrachi, M Ohsugi, MA Permutt American Journal of Physiology-Endocrinology and Metabolism 283 (4), E784-E793, 2002 | 154 | 2002 |
Admission hyperglycemia and radiological findings of SARS-CoV2 in patients with and without diabetes G Iacobellis, CA Penaherrera, LE Bermudez, EB Mizrachi Diabetes research and clinical practice 164, 108185, 2020 | 148 | 2020 |