Laurent Sabbagh
Laurent Sabbagh
Scientific Director - Domain Therapeutics
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TNF-α is critical for antitumor but not antiviral T cell immunity in mice
T Calzascia, M Pellegrini, H Hall, L Sabbagh, N Ono, AR Elford, TW Mak, ...
The Journal of clinical investigation 117 (12), 3833-3845, 2007
ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo
L Sabbagh, G Pulle, Y Liu, EN Tsitsikov, TH Watts
The Journal of Immunology 180 (12), 8093-8101, 2008
A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival
L Sabbagh, CC Srokowski, G Pulle, LM Snell, BJ Sedgmen, Y Liu, ...
Proceedings of the National Academy of Sciences 103 (49), 18703-18708, 2006
TNF family ligands define niches for T cell memory
L Sabbagh, LM Snell, TH Watts
Trends in immunology 28 (8), 333-339, 2007
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors
C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, ...
PLoS pathogens 13 (12), e1006740, 2017
The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis
L Sabbagh, SM Kaech, M Bourbonniere, M Woo, LY Cohen, EK Haddad, ...
The Journal of Immunology 173 (9), 5425-5433, 2004
Protein tyrosine phosphatase 1B is a regulator of the interleukin-10–Induced transcriptional program in macrophages
KA Pike, AP Hutchins, V Vinette, JF Théberge, L Sabbagh, ML Tremblay, ...
Science signaling 7 (324), ra43-ra43, 2014
VEGF requires the receptor NRP-1 to inhibit lipopolysaccharide-dependent dendritic cell maturation
NAE Oussa, A Dahmani, M Gomis, M Richaud, E Andreev, ...
The Journal of Immunology 197 (10), 3927-3935, 2016
Triggering of T cell activation via CD4 dimers
MC Moldovan, L Sabbagh, G Breton, RP Sékaly, MF Krummel
The Journal of Immunology 176 (9), 5438-5445, 2006
Triggering of T cell activation via CD4 dimers
MC Moldovan, L Sabbagh, G Breton, RP Sékaly, MF Krummel
The Journal of Immunology 176 (9), 5438-5445, 2006
Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells
L Sabbagh, D Andreeva, GD Laramée, NAE Oussa, D Lew, N Bisson, ...
Journal of leukocyte biology 93 (5), 713-721, 2013
Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
SH Hwang, SH Jung, S Lee, S Choi, SA Yoo, JH Park, D Hwang, SC Shim, ...
Proceedings of the National Academy of Sciences 112 (47), E6535-E6543, 2015
Pseudomonas aeruginosa PA01 Bacterial Artificial Chromosomes: Strategies for Mapping, Screening, and Sequencing 100 kb Loci of the 5.9 Mb Genome
Microbial & comparative genomics 3 (2), 105-117, 1998
Selective up-regulation of caspase-3 gene expression following TCR engagement
L Sabbagh, M Bourbonničre, RP Sékaly, LY Cohen
Molecular immunology 42 (11), 1345-1354, 2005
TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells
NAE Oussa, Y Soumounou, L Sabbagh
Biochemical and biophysical research communications 432 (1), 129-134, 2013
Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes
LY Cohen, M Bourbonniere, L Sabbagh, A Bouchard, T Chew, ...
Cell Death & Differentiation 12 (3), 243-254, 2005
Cloning and functional characterization of the murine caspase-3 gene promoter
L Sabbagh, M Bourbonničre, F Denis, RP Sékaly
DNA and cell biology 25 (2), 104-115, 2006
Regulation of tumor growth by leukocyte-specific protein 1 in T cells
R Kwon, BK Hong, KG Lee, E Choi, L Sabbagh, CS Cho, N Lee, WU Kim
Journal for Immunotherapy of Cancer 8 (2), 2020
Role of 4-1BBL and TRAF1 in the CD8 T cell response to influenza virus and HIV
TH Watts, GHY Lin, C Wang, AJ McPherson, LM Snell, L Sabbagh
Advances in TNF Family Research: Proceedings of the 12th International TNF …, 2010
Infusion of CCR5 gene-edited T cells allows immune reconstitution, HIV reservoir decay, and long-term virological control
J Zeidan, AA Sharma, G Lee, A Raad, R Fromentin, S Fourati, K Ghneim, ...
bioRxiv, 2021.02. 28.433290, 2021
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