| Hit generation in TB drug discovery: from genome to granuloma T Yuan, NS Sampson Chemical reviews 118 (4), 1887-1916, 2018 | 113 | 2018 |
| Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22 … AC Bonds, T Yuan, JM Werman, J Jang, R Lu, NM Nesbitt, M Garcia-Diaz, ... ACS infectious diseases 6 (8), 2214-2224, 2020 | 18 | 2020 |
| Mycobacterium tuberculosis Exploits a Heterohexameric Enoyl-CoA Hydratase Retro-Aldolase Complex for Cholesterol Catabolism T Yuan, M Yang, K Gehring, NS Sampson Biochemistry 58 (41), 4224-4235, 2019 | 14 | 2019 |
| Mce3R stress-resistance pathway is vulnerable to small-molecule targeting that improves tuberculosis drug activities X Yang, T Yuan, R Ma, KI Chacko, M Smith, G Deikus, R Sebra, ... ACS Infectious Diseases 5 (7), 1239-1251, 2019 | 14 | 2019 |
| The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery T Yuan, JM Werman, NS Sampson RSC chemical biology 2 (2), 423-440, 2021 | 13 | 2021 |
| Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA T Yuan, JM Werman, X Yin, M Yang, M Garcia-Diaz, NS Sampson ACS Infectious Diseases 7 (6), 1739-1751, 2021 | 12 | 2021 |
| Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis TLSA Rosa, MAM Marques, Z DeBoard, K Hutchins, CAA Silva, ... Frontiers in Cellular and Infection Microbiology 11, 709972, 2021 | 11 | 2021 |
| IpdE1-IpdE2 is a heterotetrameric acyl coenzyme A dehydrogenase that is widely distributed in steroid-degrading bacteria JE Gadbery, JW Round, T Yuan, MF Wipperman, KT Story, AM Crowe, ... Biochemistry 59 (10), 1113-1123, 2020 | 11 | 2020 |
| Polymer–multiwall carbon nantubes composites for durable all solid-contact H2PO4−-selective electrodes Y Liu, T Yuan, J Zhu, Y Qin, D Jiang Sensors and Actuators B: Chemical 219, 100-104, 2015 | 11 | 2015 |
| Corrigendum: Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis TLSA Rosa, MAM Marques, Z DeBoard, K Hutchins, CAA Silva, ... Frontiers in Cellular and Infection Microbiology 11, 765326, 2021 | 1 | 2021 |
| Azasteroids for treatment of tuberculosis N Sampson, X Yang, T Yuan US Patent 11,072,633, 2021 | 1 | 2021 |
| Correction to hit generation in Tb drug discovery: from genome to granuloma T Yuan, NS Sampson Chemical Reviews 119 (12), 7718-7718, 2019 | 1 | 2019 |
| A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria JM Werman, YC Chen, T Yuan, X Yang, NS Sampson ACS Infectious Diseases 9 (10), 1993-2004, 2023 | | 2023 |
| The Mce3R regulon is required for 6-azasteroid potentiation of anti-TB drug activity X Yang, T Yuan, R Ma, S Franzblau, N Sampson | | 2018 |
| Targeting Cholesterol Metabolism of Mycobacterium tuberculosis as a New Opportunity for Tuberculosis Drug Discovery T Yuan State University of New York at Stony Brook, 2018 | | 2018 |
| Supporting Information for The Mce3R stress-resistance pathway is vulnerable to small molecule targeting that improves tuberculosis drug activities X Yang, T Yuan, R Ma, KI Chacko, M Smith, G Deikus, R Sebra, ... | | |
Nicole SampsonUniversity Professor of Chemistry, University of RochesterVerified email at rochester.edu
