| Cu (II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction X Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, ... Journal of Biological Chemistry 274 (52), 37111-37116, 1999 | 1002 | 1999 |
| Evidence for genetic linkage of Alzheimer's disease to chromosome 10q L Bertram, D Blacker, K Mullin, D Keeney, J Jones, S Basu, S Yhu, ... Science 290 (5500), 2302-2303, 2000 | 735 | 2000 |
| Results of a high-resolution genome screen of 437 Alzheimer's disease families D Blacker, L Bertram, AJ Saunders, TJ Moscarillo, MS Albert, H Wiener, ... Human molecular genetics 12 (1), 23-32, 2003 | 441 | 2003 |
| Presenilin-mediated modulation of capacitative calcium entry AS Yoo, I Cheng, S Chung, TZ Grenfell, H Lee, E Pack-Chung, M Handler, ... Neuron 27 (3), 561-572, 2000 | 395 | 2000 |
| Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis L Puglielli, BC Ellis, AJ Saunders, DM Kovacs Journal of Biological Chemistry 278 (22), 19777-19783, 2003 | 329 | 2003 |
| Interpreting the effects of small uncharged solutes on protein-folding equilibria PR Davis-Searles, AJ Saunders, DA Erie, DJ Winzor, GJ Pielak Annual review of biophysics and biomolecular structure 30 (1), 271-306, 2001 | 327 | 2001 |
| 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote α-crystallin cross-linking by metal ion reduction LE Goldstein, MC Leopold, X Huang, CS Atwood, AJ Saunders, ... Biochemistry 39 (24), 7266-7275, 2000 | 241 | 2000 |
| MicroRNAs can regulate human APP levels N Patel, D Hoang, N Miller, S Ansaloni, Q Huang, JT Rogers, JC Lee, ... Molecular neurodegeneration 3, 1-6, 2008 | 240 | 2008 |
| MicroRNAs can regulate human APP levels N Patel, D Hoang, N Miller, S Ansaloni, Q Huang, JT Rogers, JC Lee, ... Molecular neurodegeneration 3, 1-6, 2008 | 240 | 2008 |
| Osmolyte‐induced changes in protein conformational equilibria AJ Saunders, PR Davis‐Searles, DL Allen, GJ Pielak, DA Erie Biopolymers: Original Research on Biomolecules 53 (4), 293-307, 2000 | 196 | 2000 |
| BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down syndrome region of chromosome 21 AJ Saunders, TW Kim, RE Tanzi Science 286 (5443), 1255-1255, 1999 | 186 | 1999 |
| Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects R Chakraborty, V Vepuri, SD Mhatre, BE Paddock, S Miller, SJ Michelson, ... PloS one 6 (6), e20799, 2011 | 163 | 2011 |
| Design of a Ruthenium-Cytochrome c Derivative to Measure Electron Transfer to the Initial Acceptor in Cytochrome c Oxidase (∗) LM Geren, JR Beasley, BR Fine, AJ Saunders, S Hibdon, GJ Pielak, ... Journal of Biological Chemistry 270 (6), 2466-2472, 1995 | 111 | 1995 |
| Sugar-induced molten-globule model PR Davis-Searles, AS Morar, AJ Saunders, DA Erie, GJ Pielak Biochemistry 37 (48), 17048-17053, 1998 | 101 | 1998 |
| In vivo selection for metastasis promoting genes in the mouse K Gumireddy, F Sun, AJ Klein-Szanto, JM Gibbins, PA Gimotty, ... Proceedings of the National Academy of Sciences 104 (16), 6696-6701, 2007 | 100 | 2007 |
| Role of common and rare APP DNA sequence variants in Alzheimer disease BV Hooli, G Mohapatra, M Mattheisen, AR Parrado, JT Roehr, Y Shen, ... Neurology 78 (16), 1250-1257, 2012 | 93 | 2012 |
| Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin AJ Saunders, L Bertram, K Mullin, AJ Sampson, K Latifzai, S Basu, ... Human molecular genetics 12 (21), 2765-2776, 2003 | 92 | 2003 |
| Design of a Ruthenium−Cytochrome c Derivative To Measure Electron Transfer to the Radical Cation and Oxyferryl Heme in Cytochrome c Peroxidase K Wang, H Mei, L Geren, MA Miller, A Saunders, X Wang, JL Waldner, ... Biochemistry 35 (47), 15107-15119, 1996 | 78 | 1996 |
| Synaptic abnormalities in a Drosophila model of Alzheimer’s disease SD Mhatre, V Satyasi, M Killen, BE Paddock, RD Moir, AJ Saunders, ... Disease models & mechanisms 7 (3), 373-385, 2014 | 75 | 2014 |
| Intracomplex electron transfer between ruthenium-65-cytochrome b5 and position-82 variants of yeast iso-1-cytochrome c A Willie, M McLean, RQ Liu, S Hilgen-Willis, AJ Saunders, GJ Pielak, ... Biochemistry 32 (29), 7519-7525, 1993 | 68 | 1993 |
Gary PielakKenan Distinguished Professor of Chemistry, University of North Carolina at Chapel HillVerified email at unc.edu
