Simak Ali
Simak Ali
Professor of Molecular Endocrine Oncology
Verified email at - Homepage
Cited by
Cited by
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2–positive breast cancer
J Shou, S Massarweh, CK Osborne, AE Wakeling, S Ali, H Weiss, R Schiff
Journal of the National Cancer Institute 96 (12), 926-935, 2004
Phosphatidylinositol 3-Kinase/AKT-mediated activation of estrogen receptor α A new model for anti-estrogen resistance
RA Campbell, P Bhat-Nakshatri, NM Patel, D Constantinidou, S Ali, ...
Journal of Biological Chemistry 276 (13), 9817-9824, 2001
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
CS Ross-Innes, R Stark, AE Teschendorff, KA Holmes, HR Ali, ...
Nature 481 (7381), 389-393, 2012
Endocrine-responsive breast cancer and strategies for combating resistance
S Ali, RC Coombes
Nature Reviews Cancer 2 (2), 101-112, 2002
Modulation of transcriptional activation by ligand‐dependent phosphorylation of the human oestrogen receptor A/B region.
S Ali, D Metzger, JM Bornert, P Chambon
The EMBO journal 12 (3), 1153-1160, 1993
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo
DM Vigushin, S Ali, PE Pace, N Mirsaidi, K Ito, I Adcock, RC Coombes
Clinical Cancer Research 7 (4), 971-976, 2001
Human estrogen receptor β binds DNA in a manner similar to and dimerizes with estrogen receptor α
P Pace, J Taylor, S Suntharalingam, RC Coombes, S Ali
Journal of Biological Chemistry 272 (41), 25832-25838, 1997
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
SA Eccles, EO Aboagye, S Ali, AS Anderson, J Armes, F Berditchevski, ...
Breast Cancer Research 15 (5), 1-37, 2013
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen
A Hurtado, KA Holmes, TR Geistlinger, IR Hutcheson, RI Nicholson, ...
Nature 456 (7222), 663-666, 2008
Enhanced estrogen receptor (ER) α, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
LA Martin, I Farmer, SRD Johnston, S Ali, C Marshall, M Dowsett
Journal of Biological Chemistry 278 (33), 30458-30468, 2003
Estrogen receptor alpha in human breast cancer: occurrence and significance
S Ali, RC Coombes
Journal of mammary gland biology and neoplasia 5 (3), 271-281, 2000
Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
D Chen, T Riedl, E Washbrook, PE Pace, RC Coombes, JM Egly, S Ali
Molecular cell 6 (1), 127-137, 2000
Phosphorylation of human estrogen receptor α by protein kinase A regulates dimerization
D Chen, PE Pace, RC Coombes, S Ali
Molecular and cellular biology 19 (2), 1002-1015, 1999
Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells
D Metzger, S Ali, JM Bornert, P Chambon
Journal of Biological Chemistry 270 (16), 9535-9542, 1995
Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
D Chen, E Washbrook, N Sarwar, GJ Bates, PE Pace, ...
Oncogene 21 (32), 4921-4931, 2002
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast …
A Polychronis, HD Sinnett, D Hadjiminas, H Singhal, JL Mansi, ...
The lancet oncology 6 (6), 383-391, 2005
Characterization of the gene encoding ovine beta-lactoglobulin: similarity to the genes for retinol binding protein and other secretory proteins
S Ali, AJ Clark
Journal of molecular biology 199 (3), 415-426, 1988
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity
RS Thomas, N Sarwar, F Phoenix, RC Coombes, S Ali
Journal of molecular endocrinology 40 (3), 173, 2008
Mutation analysis of cell-free DNA and single circulating tumor cells in metastatic breast cancer patients with high circulating tumor cell counts
JA Shaw, DS Guttery, A Hills, D Fernandez-Garcia, K Page, BM Rosales, ...
Clinical Cancer Research 23 (1), 88-96, 2017
Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.
D Metzger, M Berry, S Ali, P Chambon
Molecular endocrinology 9 (5), 579-591, 1995
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