Nanomole-scale high-throughput chemistry for the synthesis of complex molecules A Buitrago Santanilla, EL Regalado, T Pereira, M Shevlin, K Bateman, ... Science 347 (6217), 49-53, 2015 | 536 | 2015 |
General principles and strategies for salting-out informed by the Hofmeister series AM Hyde, SL Zultanski, JH Waldman, YL Zhong, M Shevlin, F Peng Organic Process Research & Development 21 (9), 1355-1370, 2017 | 422 | 2017 |
Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts MR Friedfeld, M Shevlin, JM Hoyt, SW Krska, MT Tudge, PJ Chirik Science 342 (6162), 1076-1080, 2013 | 363 | 2013 |
Practical high-throughput experimentation for chemists M Shevlin ACS medicinal chemistry letters 8 (6), 601-607, 2017 | 309 | 2017 |
The evolution of chemical high-throughput experimentation to address challenging problems in pharmaceutical synthesis SW Krska, DA DiRocco, SD Dreher, M Shevlin Accounts of chemical research 50 (12), 2976-2985, 2017 | 262 | 2017 |
Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction MR Friedfeld, H Zhong, RT Ruck, M Shevlin, PJ Chirik Science 360 (6391), 888-893, 2018 | 225 | 2018 |
Cobalt-catalyzed enantioselective hydrogenation of minimally functionalized alkenes: isotopic labeling provides insight into the origin of stereoselectivity and alkene … MR Friedfeld, M Shevlin, GW Margulieux, LC Campeau, PJ Chirik Journal of the American Chemical Society 138 (10), 3314-3324, 2016 | 183 | 2016 |
Nickel-catalyzed asymmetric alkene hydrogenation of α, β-unsaturated esters: high-throughput experimentation-enabled reaction discovery, optimization, and mechanistic elucidation M Shevlin, MR Friedfeld, H Sheng, NA Pierson, JM Hoyt, LC Campeau, ... Journal of the American Chemical Society 138 (10), 3562-3569, 2016 | 182 | 2016 |
Palladium‐Catalyzed Tandem Heck Reaction/C H Functionalization—Preparation of Spiro‐Indane‐Oxindoles RT Ruck, MA Huffman, MM Kim, M Shevlin, WV Kandur, IW Davies Angewandte Chemie 120 (25), 4789-4792, 2008 | 180 | 2008 |
Iridium-catalyzed X− H insertions of sulfoxonium ylides IK Mangion, IK Nwamba, M Shevlin, MA Huffman Organic Letters 11 (16), 3566-3569, 2009 | 164 | 2009 |
A concise synthesis of a β-lactamase inhibitor IK Mangion, RT Ruck, N Rivera, MA Huffman, M Shevlin Organic letters 13 (20), 5480-5483, 2011 | 139 | 2011 |
Catalytic, asymmetric, and stereodivergent synthesis of non-symmetric β, β-diaryl-α-amino acids C Molinaro, JP Scott, M Shevlin, C Wise, A Menard, A Gibb, EM Junker, ... Journal of the American Chemical Society 137 (2), 999-1006, 2015 | 106 | 2015 |
Cobalt-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids by Homolytic H2 Cleavage H Zhong, M Shevlin, PJ Chirik Journal of the American Chemical Society 142 (11), 5272-5281, 2020 | 80 | 2020 |
β-lactamase inhibitors TA Blizzard, H Chen, C Gude, JD Hermes, J Imbriglio, S Kim, JY Wu, ... US Patent 8,487,093, 2013 | 70 | 2013 |
Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant M Shevlin, X Guan, TG Driver ACS Catalysis 7 (8), 5518-5522, 2017 | 60 | 2017 |
Synthesis and hydrogenation activity of iron dialkyl complexes with chiral bidentate phosphines JM Hoyt, M Shevlin, GW Margulieux, SW Krska, MT Tudge, PJ Chirik Organometallics 33 (20), 5781-5790, 2014 | 60 | 2014 |
Asymmetric synthesis of letermovir using a novel phase-transfer-catalyzed aza-Michael reaction GR Humphrey, SM Dalby, T Andreani, B Xiang, MR Luzung, ZJ Song, ... Organic Process Research & Development 20 (6), 1097-1103, 2016 | 56 | 2016 |
Sulfate additives generate robust and highly active palladium catalysts for the cyanation of aryl chlorides M Shevlin Tetrahedron Letters 51 (37), 4833-4836, 2010 | 48 | 2010 |
Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates M Christensen, A Nolting, M Shevlin, M Weisel, PE Maligres, J Lee, ... The Journal of Organic Chemistry 81 (3), 824-830, 2016 | 46 | 2016 |
Double-Asymmetric Hydrogenation Strategy for the Reduction of 1,1-Diaryl Olefins Applied to an Improved Synthesis of CuIPhEt, a C2-Symmetric N-Heterocyclic … E Spahn, A Albright, M Shevlin, L Pauli, A Pfaltz, RE Gawley The Journal of organic chemistry 78 (6), 2731-2735, 2013 | 35 | 2013 |