Jeff Wrana
Jeff Wrana
Senior Investigator, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto; Professor, Dept. of Mol. Gen., U. of
Verified email at lunenfeld.ca
TitleCited byYear
Mechanism of activation of the TGF-β receptor
JL Wrana, L Attisano, R Wieser, F Ventura, J Massagué
Nature 370 (6488), 341, 1994
26061994
TGFβ signals through a heteromeric protein kinase receptor complex
JL Wrana, L Attisano, J Cárcamo, A Zentella, J Doody, M Laiho, XF Wang, ...
Cell 71 (6), 1003-1014, 1992
17201992
Signal transduction by the TGF-β superfamily
L Attisano, JL Wrana
Science 296 (5573), 1646-1647, 2002
16112002
The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
H Hayashi, S Abdollah, Y Qiu, J Cai, YY Xu, BW Grinnell, MA Richardson, ...
Cell 89 (7), 1165-1173, 1997
14561997
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation
P Kavsak, RK Rasmussen, CG Causing, S Bonni, H Zhu, GH Thomsen, ...
Molecular cell 6 (6), 1365-1375, 2000
13702000
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
GM Di Guglielmo, C Le Roy, AF Goodfellow, JL Wrana
Nature cell biology 5 (5), 410, 2003
11972003
SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
T Tsukazaki, TA Chiang, AF Davison, L Attisano, JL Wrana
Cell 95 (6), 779-791, 1998
11381998
Betaglycan presents ligand to the TGFβ signaling receptor
F Lopez-Casillas, JL Wrana, J Massague
Cell 73 (7), 1435-1444, 1993
9991993
MADR2 maps to 18q21 and encodes a TGFβ–regulated MAD–related protein that is functionally mutated in colorectal carcinoma
K Eppert, SW Scherer, H Ozcelik, R Pirone, P Hoodless, H Kim, LC Tsui, ...
Cell 86 (4), 543-552, 1996
9761996
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
H Zhu, P Kavsak, S Abdollah, JL Wrana, GH Thomsen
Nature 400 (6745), 687, 1999
9171999
Clathrin-and non-clathrin-mediated endocytic regulation of cell signalling
C Le Roy, JL Wrana
Nature reviews Molecular cell biology 6 (2), 112, 2005
8932005
Regulation of the polarity protein Par6 by TGFß receptors controls epithelial cell plasticity
B Ozdamar, R Bose, M Barrios-Rodiles, HR Wang, Y Zhang, JL Wrana
Science 307 (5715), 1603-1609, 2005
8662005
MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
M Macías-Silva, S Abdollah, PA Hoodless, R Pirone, L Attisano, JL Wrana
Cell 87 (7), 1215-1224, 1996
8511996
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
P Samavarchi-Tehrani, A Golipour, L David, H Sung, TA Beyer, A Datti, ...
Cell stem cell 7 (1), 64-77, 2010
8262010
MADR1, a MAD-related protein that functions in BMP2 signaling pathways
PA Hoodless, T Haerry, S Abdollah, M Stapleton, MB O'Connor, L Attisano, ...
Cell 85 (4), 489-500, 1996
8061996
Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors
L Attisano, J Carcamo, F Ventura, FMB Weis, J Massague, JL Wrana
Cell 75 (4), 671-680, 1993
7621993
GS domain mutations that constitutively activate T beta R‐I, the downstream signaling component in the TGF‐beta receptor complex.
R Wieser, JL Wrana, J Massague
The EMBO journal 14 (10), 2199-2208, 1995
7401995
High-throughput mapping of a dynamic signaling network in mammalian cells
M Barrios-Rodiles, KR Brown, B Ozdamar, R Bose, Z Liu, RS Donovan, ...
Science 307 (5715), 1621-1625, 2005
7222005
Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta.
CM Overall, JL Wrana, J Sodek
Journal of Biological Chemistry 264 (3), 1860-1869, 1989
7181989
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
V Luga, L Zhang, AM Viloria-Petit, AA Ogunjimi, MR Inanlou, E Chiu, ...
Cell 151 (7), 1542-1556, 2012
6882012
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