Improving the metabolic fidelity of cancer models with a physiological cell culture medium JV Voorde, T Ackermann, N Pfetzer, D Sumpton, G Mackay, G Kalna, ... Science Advances 5 (1), eaau7314, 2019 | 297 | 2019 |
The metabolic fate of acetate in cancer ZT Schug, JV Voorde, E Gottlieb Nature Reviews Cancer 16 (11), 708-717, 2016 | 271 | 2016 |
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation V Bulusu, S Tumanov, E Michalopoulou, NJ van den Broek, G MacKay, ... Cell Reports 18 (3), 647-658, 2017 | 223 | 2017 |
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir) L Naesens, LW Guddat, DT Keough, ABP van Kuilenburg, J Meijer, ... Molecular pharmacology 84 (4), 615-629, 2013 | 138 | 2013 |
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside C McGuigan, P Murziani, M Slusarczyk, B Gonczy, J Vande Voorde, ... Journal of medicinal chemistry 54 (20), 7247-7258, 2011 | 138 | 2011 |
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine JV Voorde, S Sabuncuoğlu, S Noppen, A Hofer, F Ranjbarian, S Fieuws, ... Journal of Biological Chemistry 289 (19), 13054-13065, 2014 | 133 | 2014 |
Increased formate overflow is a hallmark of oxidative cancer J Meiser, A Schuster, M Pietzke, JV Voorde, D Athineos, K Oizel, ... Nature Communications 9 (1), 1368, 2018 | 97 | 2018 |
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer JC Casciano, C Perry, AJ Cohen-Nowak, KD Miller, JV Voorde, Q Zhang, ... British journal of cancer 122 (6), 868-884, 2020 | 71 | 2020 |
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2′-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by … J Vande Voorde, S Liekens, C McGuigan, PGS Murziani, M Slusarczyk, ... Biochemical pharmacology 82 (5), 441-452, 2011 | 53* | 2011 |
Mycoplasmas and cancer: focus on nucleoside metabolism JV Voorde, J Balzarini, S Liekens EXCLI journal 13, 300, 2014 | 42 | 2014 |
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics J Balzarini, K Das, JA Bernatchez, SE Martinez, M Ngure, S Keane, ... Proceedings of the National Academy of Sciences 112 (11), 3475-3480, 2015 | 37 | 2015 |
Evidence for the presence of Legionella bacteriophages in environmental water samples E Lammertyn, JV Voorde, E Meyen, L Maes, J Mast, J Anné Microbial ecology 56 (1), 191-197, 2008 | 30 | 2008 |
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: Novel 5-fluorouracil analogs that target thymidylate synthase N Tzioumaki, S Manta, E Tsoukala, VV Johan, S Liekens, D Komiotis, ... European journal of medicinal chemistry 46 (4), 993-1005, 2011 | 29 | 2011 |
The pathogenesis of mesothelioma is driven by a dysregulated translatome S Grosso, A Marini, K Gyuraszova, JV Voorde, A Sfakianos, GD Garland, ... Nature Communications 12 (1), 1-17, 2021 | 27 | 2021 |
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues JV Voorde, F Gago, K Vrancken, S Liekens, J Balzarini Biochemical Journal 445 (1), 113-123, 2012 | 27 | 2012 |
Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs J Vande Voorde, P Vervaeke, S Liekens, J Balzarini FEBS open bio 5 (1), 634-639, 2015 | 22 | 2015 |
The Nurture of Tumors Can Drive Their Metabolic Phenotype ZT Schug, JV Voorde, E Gottlieb Cell metabolism 23 (3), 391-392, 2016 | 17 | 2016 |
Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression R Patel, CA Ford, L Rodgers, LK Rushworth, J Fleming, E Mui, T Zhang, ... Cancer Research 82 (14), 2565-2575, 2022 | 16 | 2022 |
Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase A Gigante, EM Priego, P Sánchez-Carrasco, LM Ruiz-Pérez, JV Voorde, ... European journal of medicinal chemistry 82, 459-465, 2014 | 16 | 2014 |
Mycoplasma hyorhinis–Encoded Purine Nucleoside Phosphorylase: Kinetic Properties and Its Effect on the Cytostatic Potential of Purine-Based Anticancer Drugs JV Voorde, S Liekens, J Balzarini Molecular pharmacology 84 (6), 865-875, 2013 | 12 | 2013 |