Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor G Hultqvist, S Syvänen, XT Fang, L Lannfelt, D Sehlin Theranostics 7 (2), 308, 2017 | 166 | 2017 |
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1 X Wang, B Hu, A Zieba, NG Neumann, M Kasper-Sonnenberg, ... Journal of Neuroscience 29 (40), 12584-12596, 2009 | 110 | 2009 |
Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells XT Fang, D Sehlin, L Lannfelt, S Syvänen, G Hultqvist Biological procedures online 19, 1-9, 2017 | 90 | 2017 |
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site C Limbach, MM Laue, X Wang, B Hu, N Thiede, G Hultqvist, MW Kilimann Proceedings of the National Academy of Sciences 108 (31), E392-E401, 2011 | 87 | 2011 |
High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain XT Fang, G Hultqvist, SR Meier, G Antoni, D Sehlin, S Syvänen Neuroimage 184, 881-888, 2019 | 63 | 2019 |
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody S Syvänen, G Hultqvist, T Gustavsson, A Gumucio, H Laudon, ... Alzheimer's Research & Therapy 10, 1-10, 2018 | 60 | 2018 |
A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils–a new concept for neuroimaging S Syvänen, XT Fang, G Hultqvist, SR Meier, L Lannfelt, D Sehlin Neuroimage 148, 55-63, 2017 | 58 | 2017 |
Antibody-based in vivo PET imaging detects amyloid-β reduction in Alzheimer transgenic mice after BACE-1 inhibition SR Meier, S Syvänen, G Hultqvist, XT Fang, S Roshanbin, L Lannfelt, ... Journal of Nuclear Medicine 59 (12), 1885-1891, 2018 | 51 | 2018 |
Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. D Sehlin, P Stocki, T Gustavsson, G Hultqvist, FS Walsh, JL Rutkowski, ... The FASEB Journal 34 (10), 13272-13283, 2020 | 47 | 2020 |
Probing the role of backbone hydrogen bonds in protein–peptide interactions by amide-to-ester mutations JNN Eildal, G Hultqvist, T Balle, N Stuhr-Hansen, S Padrah, S Gianni, ... Journal of the American Chemical Society 135 (35), 12998-13007, 2013 | 46 | 2013 |
Emergence and evolution of an interaction between intrinsically disordered proteins G Hultqvist, E Åberg, C Camilloni, GN Sundell, E Andersson, J Dogan, ... Elife 6, e16059, 2017 | 44 | 2017 |
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains SR Haq, CN Chi, A Bach, J Dogan, Å Engström, G Hultqvist, ... Journal of the American Chemical Society 134 (1), 599-605, 2012 | 44 | 2012 |
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins P Jemth, E Karlsson, B Vögeli, B Guzovsky, E Andersson, G Hultqvist, ... Science advances 4 (10), eaau4130, 2018 | 41 | 2018 |
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations SW Pedersen, SB Pedersen, L Anker, G Hultqvist, AS Kristensen, P Jemth, ... Nature communications 5 (1), 3215, 2014 | 41 | 2014 |
Energetic pathway sampling in a protein interaction domain G Hultqvist, SR Haq, AS Punekar, CN Chi, Å Engström, A Bach, ... Structure 21 (7), 1193-1202, 2013 | 39 | 2013 |
Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy S Gustafsson, T Gustavsson, S Roshanbin, G Hultqvist, ... Neuropharmacology 143, 1-9, 2018 | 37 | 2018 |
Evolution of the p53-MDM2 pathway E Åberg, F Saccoccia, M Grabherr, WYJ Ore, P Jemth, G Hultqvist BMC Evolutionary Biology 17, 1-12, 2017 | 33 | 2017 |
In vivo imaging of alpha-synuclein with antibody-based PET S Roshanbin, M Xiong, G Hultqvist, L Söderberg, O Zachrisson, S Meier, ... Neuropharmacology 208, 108985, 2022 | 30 | 2022 |
Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta F Rofo, J Buijs, R Falk, K Honek, L Lannfelt, AM Lilja, NG Metzendorf, ... Translational neurodegeneration 10, 1-16, 2021 | 28 | 2021 |
Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain F Rofo, CU Yilmaz, N Metzendorf, T Gustavsson, C Beretta, A Erlandsson, ... Theranostics 11 (2), 789, 2021 | 26 | 2021 |