| MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 535 | 2014 |
| Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation T Visnes, A Cázares-Körner, W Hao, O Wallner, G Masuyer, O Loseva, ... Science 362 (6416), 834-839, 2018 | 192 | 2018 |
| NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine NCK Valerie, A Hagenkort, BDG Page, G Masuyer, D Rehling, M Carter, ... Cancer research 76 (18), 5501-5511, 2016 | 109 | 2016 |
| Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitor R Gustafsson, AS Jemth, NMS Gustafsson, K Färnegårdh, O Loseva, ... Cancer research 77 (4), 937-948, 2017 | 76 | 2017 |
| Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells BDG Page, NCK Valerie, RHG Wright, O Wallner, R Isaksson, M Carter, ... Nature communications 9 (1), 250, 2018 | 72 | 2018 |
| 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and … L Johansson, C Fotsch, MD Bartberger, VM Castro, M Chen, M Emery, ... Journal of medicinal chemistry 51 (10), 2933-2943, 2008 | 61 | 2008 |
| Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition L Bräutigam, L Pudelko, AS Jemth, H Gad, M Narwal, R Gustafsson, ... Cancer research 76 (8), 2366-2375, 2016 | 52 | 2016 |
| Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein M Geitmann, K Retra, GE de Kloe, E Homan, AB Smit, IJP de Esch, ... Biochemistry 49 (37), 8143-8154, 2010 | 49 | 2010 |
| Target 2035–update on the quest for a probe for every protein S Müller, S Ackloo, A Al Chawaf, B Al-Lazikani, A Antolin, JB Baell, ... RSC Medicinal Chemistry 13 (1), 13-21, 2022 | 41 | 2022 |
| Targeting OGG1 arrests cancer cell proliferation by inducing replication stress T Visnes, C Benítez-Buelga, A Cázares-Körner, K Sanjiv, BMF Hanna, ... Nucleic acids research 48 (21), 12234-12251, 2020 | 41 | 2020 |
| dUTPase inhibition augments replication defects of 5-Fluorouracil A Hagenkort, CBJ Paulin, M Desroses, A Sarno, E Wiita, O Mortusewicz, ... Oncotarget 8 (14), 23713, 2017 | 41 | 2017 |
| Fragment-based discovery and optimization of enzyme inhibitors by docking of commercial chemical space A Rudling, R Gustafsson, I Almlof, E Homan, M Scobie, ... Journal of Medicinal Chemistry 60 (19), 8160-8169, 2017 | 39 | 2017 |
| A multiway 3D QSAR analysis of a series of (S)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxybenzamides J Nilsson, EJ Homan, AK Smilde, CJ Grol, H Wikström Journal of computer-aided molecular design 12, 81-93, 1998 | 32 | 1998 |
| Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress N Bonagas, NMS Gustafsson, M Henriksson, P Marttila, R Gustafsson, ... Nature cancer 3 (2), 156-172, 2022 | 29 | 2022 |
| 2-aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: a novel class of potential atypical antipsychotic … EJ Homan, S Copinga, L Elfström, T van der Veen, JP Hallema, N Mohell, ... Bioorganic & medicinal chemistry 6 (11), 2111-2126, 1998 | 28 | 1998 |
| Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT EJ Homan, HV Wikström, CJ Grol Bioorganic & medicinal chemistry 7 (9), 1805-1820, 1999 | 27 | 1999 |
| Computational and experimental druggability assessment of human DNA glycosylases M Michel, T Visnes, EJ Homan, B Seashore-Ludlow, M Hedenström, ... ACS omega 4 (7), 11642-11656, 2019 | 23 | 2019 |
| Piperazin-1-ylpyridazine derivatives are a novel class of human dCTP pyrophosphatase 1 inhibitors S Llona-Minguez, A Hoglund, A Ghassemian, M Desroses, ... Journal of medicinal chemistry 60 (10), 4279-4292, 2017 | 22 | 2017 |
| Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1 S Llona-Minguez, A Hoglund, E Wiita, I Almlof, A Mateus, ... Journal of Medicinal Chemistry 60 (5), 2148-2154, 2017 | 18 | 2017 |
| Exogenous melatonin entrains rhythm and reduces amplitude of endogenous melatonin: an in vivo microdialysis study WJ Drijfhout, EJ Homan, HF Brons, NR Oakley, M Skingle, CJ Grol, ... Journal of pineal research 20 (1), 24-32, 1996 | 18 | 1996 |
