Alexandra Cousido-Siah
Alexandra Cousido-Siah
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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
D Martinez-Zapien, FX Ruiz, J Poirson, A Mitschler, J Ramirez, A Forster, ...
Nature 529 (7587), 541-545, 2016
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase
MP Blakeley, F Ruiz, R Cachau, I Hazemann, F Meilleur, A Mitschler, ...
Proceedings of the National Academy of Sciences 105 (6), 1844-1848, 2008
Modulation of aldose reductase inhibition by halogen bond tuning
J Fanfrlik, M Kolar, M Kamlar, D Hurny, FX Ruiz, A Cousido-Siah, ...
ACS Chemical Biology 8 (11), 2484-2492, 2013
Neutron structure of type‐III antifreeze protein allows the reconstruction of AFP–ice interface
EI Howard, MP Blakeley, M Haertlein, IP Haertlein, A Mitschler, SJ Fisher, ...
Journal of Molecular Recognition 24 (4), 724-732, 2011
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment ofá…
MC Van Zandt, DL Whitehouse, A Golebiowski, MK Ji, M Zhang, ...
Journal of medicinal chemistry 56 (6), 2568-2580, 2013
Iminosugar‐Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels
ML Lepage, JP Schneider, A Bodlenner, A Meli, F De Riccardis, M Schmitt, ...
Chemistry–A European Journal 22 (15), 5151-5155, 2016
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutantá…
T Petrova, H Steuber, I Hazemann, A Cousido-Siah, A Mitschler, R Chung, ...
Journal of medicinal chemistry 48 (18), 5659-5665, 2005
Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10
FAC Klein, G Zeder-Lutz, A Cousido-Siah, A Mitschler, A Katz, P Eberling, ...
Human molecular genetics 22 (20), 4215-4223, 2013
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
M Celegato, L Messa, L Goracci, B Mercorelli, C Bertagnin, F Spyrakis, ...
Cancer Letters 470, 115-125, 2020
The effect of halogen-to-hydrogen bond substitution on human aldose reductase inhibition
J Fanfrlik, FX Ruiz, A Kadlcikova, J Rezac, A Cousido-Siah, A Mitschler, ...
ACS chemical biology 10 (7), 1637-1642, 2015
Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition
E Howard, A Cousido‐Siah, ML Lepage, JP Schneider, A Bodlenner, ...
Angewandte Chemie International Edition 57 (27), 8002-8006, 2018
Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction
A Golebiowski, D Whitehouse, RP Beckett, M Van Zandt, MK Ji, TR Ryder, ...
Bioorganic & medicinal chemistry letters 23 (17), 4837-4841, 2013
X-ray crystal structure of the full length human chitotriosidase (CHIT1) reveals features of its chitin binding domain
F Fadel, Y Zhao, A Cousido-Siah, FX Ruiz, A Mitschler, A Podjarny
PloS one 11 (4), e0154190, 2016
High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP–oleic acid complex: study of the internal water cluster and ligand binding by a transferredá…
EI Howard, B Guillot, MP Blakeley, M Haertlein, M Moulin, A Mitschler, ...
IUCrJ 3 (2), 115-126, 2016
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors
A Golebiowski, RP Beckett, M Van Zandt, MK Ji, D Whitehouse, TR Ryder, ...
Bioorganic & medicinal chemistry letters 23 (7), 2027-2030, 2013
Dual specificity PDZ-and 14-3-3-binding motifs: a structural and interactomics study
G Gogl, P Jane, C Caillet-Saguy, C Kostmann, G Bich, A Cousido-Siah, ...
Structure 28 (7), 747-759. e3, 2020
Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes andá…
A Cousido-Siah, FX Ruiz, A Mitschler, S PortÚ, ┴R De Lera, MJ Martin, ...
Acta Crystallographica Section D: Biological Crystallography 70 (3), 889-903, 2014
New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
F Fadel, Y Zhao, R Cachau, A Cousido-Siah, FX Ruiz, K Harlos, ...
Acta Crystallographica Section D: Biological Crystallography 71 (7), 1455-1470, 2015
Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido [4, 5-c] quinoline-2-acetic acid derivatives as selective and potentá…
I Crespo, J Gimenez-Dejoz, S Porte, A Cousido-Siah, A Mitschler, ...
European Journal of Medicinal Chemistry 152, 160-174, 2018
Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10
A Cousido-Siah, FX Ruiz, I Crespo, S Porte, A Mitschler, X Pares, ...
Chemico-biological interactions 234, 290-296, 2015
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