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Colleen Niswender
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Metabotropic glutamate receptors: physiology, pharmacology, and disease
CM Niswender, PJ Conn
Annual review of pharmacology and toxicology 50, 295-322, 2010
21492010
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
CM Burns, H Chu, SM Rueter, LK Hutchinson, H Canton, E Sanders-Bush, ...
Nature 387 (6630), 303-308, 1997
12081997
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
H Wu, C Wang, KJ Gregory, GW Han, HP Cho, Y Xia, CM Niswender, ...
Science 344 (6179), 58-64, 2014
5832014
RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity
CM Niswender, SC Copeland, K Herrick-Davis, RB Emeson, ...
Journal of Biological Chemistry 274 (14), 9472-9478, 1999
4341999
Glutamate receptors as therapeutic targets for Parkinson's disease
KA Johnson, PJ Conn, CM Niswender
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2009
3142009
RNA editing of the human serotonin 5-HT2C receptor: alterations in suicide and implications for serotonergic pharmacotherapy
CM Niswender, K Herrick-Davis, GE Dilley, HY Meltzer, JC Overholser, ...
Neuropsychopharmacology 24 (5), 478-491, 2001
3082001
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
PJ Conn, CW Lindsley, J Meiler, CM Niswender
Nature reviews Drug discovery 13 (9), 692-708, 2014
2742014
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery
BJ Melancon, CR Hopkins, MR Wood, KA Emmitte, CM Niswender, ...
Journal of medicinal chemistry 55 (4), 1445-1464, 2012
2532012
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4
CM Niswender, KA Johnson, CD Weaver, CK Jones, Z Xiang, Q Luo, ...
Molecular pharmacology 74 (5), 1345-1358, 2008
2322008
Serotonin 5‐HT2C Receptor RNA Editing Alters Receptor Basal Activity: Implications for Serotonergic Signal Transduction
K Herrick‐Davis, E Grinde, CM Niswender
Journal of neurochemistry 73 (4), 1711-1717, 1999
2201999
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of …
AL Rodriguez, MD Grier, CK Jones, EJ Herman, AS Kane, RL Smith, ...
Molecular pharmacology 78 (6), 1105-1123, 2010
2062010
Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine
SM Rueter, CM Burns, SA Coode, P Mookherjee, RB Emeson
Science 267 (5203), 1491-1494, 1995
1981995
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
JK Shirey, Z Xiang, D Orton, AE Brady, KA Johnson, R Williams, JE Ayala, ...
Nature chemical biology 4 (1), 42-50, 2008
1762008
RNA‐editing of the 5‐HT2C receptor alters agonist‐receptor‐effector coupling specificity
KA Berg, JD Cropper, CM Niswender, E Sanders‐Bush, RB Emeson, ...
British journal of pharmacology 134 (2), 386-392, 2001
1752001
Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors
CW Lindsley, KA Emmitte, CR Hopkins, TM Bridges, KJ Gregory, ...
Chemical reviews 116 (11), 6707-6741, 2016
1742016
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity
JE Marlo, CM Niswender, EL Days, TM Bridges, Y Xiang, AL Rodriguez, ...
Molecular pharmacology 75 (3), 577-588, 2009
1682009
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice
K Kaufmann, I Romaine, E Days, C Pascual, A Malik, L Yang, B Zou, Y Du, ...
ACS chemical neuroscience 4 (9), 1278-1286, 2013
1572013
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
DJ Sheffler, R Williams, TM Bridges, Z Xiang, AS Kane, NE Byun, ...
Molecular pharmacology 76 (2), 356-368, 2009
1402009
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors
CM Niswender, KA Johnson, Q Luo, JE Ayala, C Kim, PJ Conn, ...
Molecular pharmacology 73 (4), 1213-1224, 2008
1322008
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
M Bubser, TM Bridges, D Dencker, RW Gould, M Grannan, MJ Noetzel, ...
ACS chemical neuroscience 5 (10), 920-942, 2014
1312014
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