| Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility EM Williams, RF Little, AM Mowday, MH Rich, JVE Chan-Hyams, ... Biochemical journal 471 (2), 131-153, 2015 | 142 | 2015 |
| Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954 GA Prosser, JN Copp, SP Syddall, EM Williams, JB Smaill, WR Wilson, ... Biochemical pharmacology 79 (5), 678-687, 2010 | 128 | 2010 |
| Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily E Akiva, JN Copp, N Tokuriki, PC Babbitt Proceedings of the National Academy of Sciences 114 (45), E9549-E9558, 2017 | 122 | 2017 |
| The phosphopantetheinyl transferase superfamily: phylogenetic analysis and functional implications in cyanobacteria JN Copp, BA Neilan Applied and environmental microbiology 72 (4), 2298-2305, 2006 | 82 | 2006 |
| Evolution of enzyme superfamilies: comprehensive exploration of sequence–function relationships F Baier, JN Copp, N Tokuriki Biochemistry 55 (46), 6375-6388, 2016 | 77 | 2016 |
| Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy JN Copp, AM Mowday, EM Williams, CP Guise, A Ashoorzadeh, ... Cell Chemical Biology 24 (3), 391-403, 2017 | 74 | 2017 |
| Directed evolution library creation EMJ Gillam, JN Copp, DF Ackerley Methods in molecular biology 179, 2014 | 71 | 2014 |
| Revealing unexplored sequence-function space using sequence similarity networks JN Copp, E Akiva, PC Babbitt, N Tokuriki Biochemistry 57 (31), 4651-4662, 2018 | 68 | 2018 |
| Rapid and flexible biochemical assays for evaluating 4′-phosphopantetheinyl transferase activity JG Owen, JN Copp, DF Ackerley Biochemical Journal 436 (3), 709-717, 2011 | 65 | 2011 |
| Characterization of nitrogen-fixing cyanobacteria in the Brazilian Amazon floodplain M de Fátima Fiore, BA Neilan, JN Copp, JLM Rodrigues, SM Tsai, H Lee, ... Water research 39 (20), 5017-5026, 2005 | 63 | 2005 |
| Error-prone PCR and effective generation of gene variant libraries for directed evolution JN Copp, P Hanson-Manful, DF Ackerley, WM Patrick Directed Evolution Library Creation: Methods and Protocols, 3-22, 2014 | 61 | 2014 |
| A revised biosynthetic pathway for the cofactor F420 in prokaryotes G Bashiri, J Antoney, ENM Jirgis, MV Shah, B Ney, J Copp, SM Stuteley, ... Nature communications 10 (1), 1558, 2019 | 59 | 2019 |
| Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A GA Prosser, JN Copp, AM Mowday, CP Guise, SP Syddall, EM Williams, ... Biochemical pharmacology 85 (8), 1091-1103, 2013 | 59 | 2013 |
| Polyphasic detection of cyanobacteria in terrestrial biofilms CC Gaylarde, PM Gaylarde, J Copp, B Neilan Biofouling 20 (2), 71-79, 2004 | 42 | 2004 |
| Site-saturation mutagenesis by overlap extension PCR EM Williams, JN Copp, DF Ackerley Directed Evolution Library Creation: Methods and Protocols, 83-101, 2014 | 38 | 2014 |
| Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954 PM Swe, JN Copp, LK Green, CP Guise, AM Mowday, JB Smaill, ... Biochemical pharmacology 84 (6), 775-783, 2012 | 37 | 2012 |
| Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs JN Copp, EM Williams, MH Rich, AV Patterson, JB Smaill, DF Ackerley Protein Engineering, Design & Selection 27 (10), 399-403, 2014 | 32 | 2014 |
| The flavin reductase MsuE is a novel nitroreductase that can efficiently activate two promising next-generation prodrugs for gene-directed enzyme prodrug therapy LK Green, MA Storey, EM Williams, AV Patterson, JB Smaill, JN Copp, ... Cancers 5 (3), 985-997, 2013 | 32 | 2013 |
| Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections DA Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden ... mBio 11 (5), e02068-20, 2020 | 31* | 2020 |
| Characterization of PPTNs, a Cyanobacterial Phosphopantetheinyl Transferase from Nodularia spumigena NSOR10 JN Copp, AA Roberts, MA Marahiel, BA Neilan Journal of bacteriology 189 (8), 3133-3139, 2007 | 27 | 2007 |
Dave AckerleyBiotechnology Programme Director, Victoria University of WellingtonVerified email at vuw.ac.nz
