| The BioPlex network: a systematic exploration of the human interactome EL Huttlin, L Ting, RJ Bruckner, F Gebreab, MP Gygi, J Szpyt, S Tam, ... Cell 162 (2), 425-440, 2015 | 1413 | 2015 |
| Architecture of the human interactome defines protein communities and disease networks EL Huttlin, RJ Bruckner, JA Paulo, JR Cannon, L Ting, K Baltier, G Colby, ... Nature 545 (7655), 505-509, 2017 | 1361 | 2017 |
| The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy JM Heo, A Ordureau, JA Paulo, J Rinehart, JW Harper Molecular cell 60 (1), 7-20, 2015 | 770 | 2015 |
| Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I K Yamamoto, A Venida, J Yano, DE Biancur, M Kakiuchi, S Gupta, ... Nature 581 (7806), 100-105, 2020 | 743 | 2020 |
| Dual proteome-scale networks reveal cell-specific remodeling of the human interactome EL Huttlin, RJ Bruckner, J Navarrete-Perea, JR Cannon, K Baltier, ... Cell 184 (11), 3022-3040. e28, 2021 | 568 | 2021 |
| Detection and quantitation of circulating human irisin by tandem mass spectrometry MP Jedrychowski, CD Wrann, JA Paulo, KK Gerber, J Szpyt, ... Cell metabolism 22 (4), 734-740, 2015 | 543 | 2015 |
| Excessive cell growth causes cytoplasm dilution and contributes to senescence GE Neurohr, RL Terry, J Lengefeld, M Bonney, GP Brittingham, F Moretto, ... cell 176 (5), 1083-1097. e18, 2019 | 405 | 2019 |
| TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples J Li, JG Van Vranken, L Pontano Vaites, DK Schweppe, EL Huttlin, ... Nature methods 17 (4), 399-404, 2020 | 347 | 2020 |
| Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy A Ordureau, JM Heo, DM Duda, JA Paulo, JL Olszewski, D Yanishevski, ... Proceedings of the National Academy of Sciences 112 (21), 6637-6642, 2015 | 321 | 2015 |
| A quantitative tissue-specific landscape of protein redox regulation during aging H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ... Cell 180 (5), 968-983. e24, 2020 | 260 | 2020 |
| Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism DE Biancur, JA Paulo, B Małachowska, M Quiles Del Rey, CM Sousa, ... Nature communications 8 (1), 15965, 2017 | 256 | 2017 |
| Streamlined tandem mass tag (SL-TMT) protocol: an efficient strategy for quantitative (phospho) proteome profiling using tandem mass tag-synchronous precursor selection-MS3 J Navarrete-Perea, Q Yu, SP Gygi, JA Paulo Journal of proteome research 17 (6), 2226-2236, 2018 | 252 | 2018 |
| Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling J Paek, M Kalocsay, DP Staus, L Wingler, R Pascolutti, JA Paulo, SP Gygi, ... Cell 169 (2), 338-349. e11, 2017 | 246 | 2017 |
| Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells K Furuyama, S Chera, L van Gurp, D Oropeza, L Ghila, N Damond, ... Nature 567 (7746), 43-48, 2019 | 234 | 2019 |
| TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress H An, A Ordureau, JA Paulo, CJ Shoemaker, V Denic, JW Harper Molecular cell 74 (5), 891-908. e10, 2019 | 220 | 2019 |
| The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondria JZ Long, KJ Svensson, LA Bateman, H Lin, T Kamenecka, IA Lokurkar, ... Cell 166 (2), 424-435, 2016 | 218 | 2016 |
| An ancient, unified mechanism for metformin growth inhibition in C. elegans and cancer L Wu, B Zhou, N Oshiro-Rapley, M Li, JA Paulo, CM Webster, F Mou, ... Cell 167 (7), 1705-1718. e13, 2016 | 211 | 2016 |
| Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation DC Scott, DY Rhee, DM Duda, IR Kelsall, JL Olszewski, JA Paulo, ... Cell 166 (5), 1198-1214. e24, 2016 | 207 | 2016 |
| Probing the global cellular responses to lipotoxicity caused by saturated fatty acids M Piccolis, LM Bond, M Kampmann, P Pulimeno, C Chitraju, CBK Jayson, ... Molecular cell 74 (1), 32-44. e8, 2019 | 205 | 2019 |
| Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics DK Schweppe, JK Eng, Q Yu, D Bailey, R Rad, J Navarrete-Perea, ... Journal of proteome research 19 (5), 2026-2034, 2020 | 195 | 2020 |
