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Andrew M. Pickering Ph.D.
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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes
AM Pickering, AL Koop, CY Teoh, G Ermak, T Grune, KJA Davies
Biochemical Journal 432 (3), 585-595, 2010
3602010
Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress
AM Pickering, RA Linder, H Zhang, HJ Forman, KJA Davies
Journal of Biological Chemistry 287 (13), 10021-10031, 2012
3052012
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress
T Grune, B Catalgol, A Licht, G Ermak, AM Pickering, JK Ngo, KJA Davies
Free Radical Biology and Medicine 51 (7), 1355-1364, 2011
2232011
Degradation of damaged proteins: the main function of the 20S proteasome
AM Pickering, KJA Davies
Progress in molecular biology and translational science 109, 227-248, 2012
2042012
Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins
AM Pickering, KJA Davies
Archives of biochemistry and biophysics 523 (2), 181-190, 2012
1552012
Oxidative stress adaptation with acute, chronic, and repeated stress
AM Pickering, L Vojtovich, J Tower, KJA Davies
Free Radical Biology and Medicine 55, 109-118, 2013
1472013
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours
Z Zhu, A Achreja, N Meurs, O Animasahun, S Owen, A Mittal, P Parikh, ...
Nature Metabolism 2 (8), 775-792, 2020
1172020
A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
AM Pickering, TA Staab, J Tower, D Sieburth, KJA Davies
Journal of Experimental Biology 216 (4), 543-553, 2013
1042013
Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
ES Chocron, E Munkácsy, AM Pickering
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (2), 285-297, 2019
872019
Lifespan of mice and primates correlates with immunoproteasome expression
AM Pickering, M Lehr, RA Miller
The Journal of clinical investigation 125 (5), 2059-2068, 2015
792015
Fibroblasts from longer-lived species of primates, rodents, bats, carnivores, and birds resist protein damage
AM Pickering, M Lehr, WJ Kohler, ML Han, RA Miller
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2015
402015
Proline-and arginine-rich peptides as flexible allosteric modulators of human proteasome activity
M Giżyńska, J Witkowska, P Karpowicz, R Rostankowski, ES Chocron, ...
Journal of Medicinal Chemistry 62 (1), 359-370, 2018
372018
A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis
AM Pickering, KJA Davies
Free Radical Biology and Medicine 52 (2), 239-246, 2012
342012
Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
E Munkácsy, ES Chocron, L Quintanilla, CM Gendron, SD Pletcher, ...
Aging cell 18 (5), e13005, 2019
272019
Mitochondrial thioredoxin reductase 2 is elevated in long‐lived primate as well as rodent species and extends fly mean lifespan
AM Pickering, M Lehr, CM Gendron, SD Pletcher, RA Miller
Aging Cell 16 (4), 683-692, 2017
272017
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
ES Chocron, E Munkácsy, HS Kim, P Karpowicz, N Jiang, CE Van Skike, ...
Science advances 8 (23), eabk2252, 2022
252022
Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
SV Nuzhdin, JA Brisson, A Pickering, ML Wayne, LG Harshman, ...
BMC genomics 10, 1-12, 2009
202009
Gut-and oral-dysbiosis differentially impact spinal-and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset
HS Kim, J Son, D Lee, J Tsai, D Wang, ES Chocron, S Jeong, P Kittrell, ...
BMC neurology 22 (1), 62, 2022
182022
New peptide-based pharmacophore activates 20S proteasome
PA Osmulski, P Karpowicz, E Jankowska, J Bohmann, AM Pickering, ...
Molecules 25 (6), 1439, 2020
152020
The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
K Davidson, AM Pickering
Frontiers in Cell and Developmental Biology 11, 1124907, 2023
122023
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Articles 1–20