| Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene/allele-specific silencing of mutant huntingtin JB Carroll, SC Warby, AL Southwell, CN Doty, S Greenlee, N Skotte, ... Molecular Therapy 19 (12), 2178-2185, 2011 | 244 | 2011 |
| CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup SC Warby, A Montpetit, AR Hayden, JB Carroll, SL Butland, H Visscher, ... The American Journal of Human Genetics 84 (3), 351-366, 2009 | 225 | 2009 |
| Automated deformation analysis in the YAC128 Huntington disease mouse model JP Lerch, JB Carroll, S Spring, LN Bertram, C Schwab, MR Hayden, ... Neuroimage 39 (1), 32-39, 2008 | 162 | 2008 |
| Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease PR Joshi, NP Wu, VM André, DM Cummings, C Cepeda, JA Joyce, ... Journal of Neuroscience 29 (8), 2414-2427, 2009 | 155 | 2009 |
| Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ... Human molecular genetics 17 (15), 2390-2404, 2008 | 135 | 2008 |
| Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes M Valenza, V Leoni, JM Karasinska, L Petricca, J Fan, J Carroll, ... Journal of Neuroscience 30 (32), 10844-10850, 2010 | 126 | 2010 |
| Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo RK Graham, Y Deng, J Carroll, K Vaid, C Cowan, MA Pouladi, M Metzler, ... Journal of Neuroscience 30 (45), 15019-15029, 2010 | 118 | 2010 |
| Treating the whole body in Huntington's disease JB Carroll, GP Bates, J Steffan, C Saft, SJ Tabrizi The Lancet Neurology 14 (11), 1135-1142, 2015 | 115 | 2015 |
| Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ... PloS one 9 (9), e107434, 2014 | 112 | 2014 |
| In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ... Molecular Therapy 22 (12), 2093-2106, 2014 | 110 | 2014 |
| Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease JP Lerch, JB Carroll, A Dorr, S Spring, AC Evans, MR Hayden, JG Sled, ... Neuroimage 41 (2), 243-251, 2008 | 109 | 2008 |
| Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain JM Van Raamsdonk, M Metzler, E Slow, J Pearson, C Schwab, J Carroll, ... Neurobiology of disease 26 (1), 189-200, 2007 | 105 | 2007 |
| Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation M Valenza, JB Carroll, V Leoni, LN Bertram, I Björkhem, RR Singaraja, ... Human molecular genetics 16 (18), 2187-2198, 2007 | 101 | 2007 |
| Parvoviral nuclear import: bypassing the host nuclear-transport machinery S Cohen, AR Behzad, JB Carroll, N Pante Journal of general virology 87 (11), 3209-3213, 2006 | 77 | 2006 |
| Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease JB Carroll, JP Lerch, S Franciosi, A Spreeuw, N Bissada, RM Henkelman, ... Neurobiology of disease 43 (1), 257-265, 2011 | 76 | 2011 |
| A fully humanized transgenic mouse model of Huntington disease AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ... Human molecular genetics 22 (1), 18-34, 2013 | 74 | 2013 |
| Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14 K Huang, SS Sanders, R Kang, JB Carroll, L Sutton, J Wan, R Singaraja, ... Human molecular genetics 20 (17), 3356-3365, 2011 | 67 | 2011 |
| Cerebrospinal fluid levels of orexin‐A are not a clinically useful biomarker for Huntington disease M Björkqvist, Å Petersén, J Nielsen, D Ecker, H Mulder, MR Hayden, ... Clinical genetics 70 (1), 78-79, 2006 | 40 | 2006 |
| Antisense oligonucleotides extend survival of prion-infected mice GJ Raymond, HT Zhao, B Race, LD Raymond, K Williams, EE Swayze, ... JCI insight 4 (16), 2019 | 38 | 2019 |
| High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds SA Ament, JR Pearl, A Grindeland, J St Claire, JC Earls, M Kovalenko, ... Human molecular genetics 26 (5), 913-922, 2017 | 33 | 2017 |
Michael HaydenKillam Professor, University of British ColumbiaVerified email at cmmt.ubc.ca
