Lu Chao
Lu Chao
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ...
Cancer cell 18 (6), 553-567, 2010
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ...
Nature, 2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation
C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ...
Nature, 2012
Metabolic Regulation of Epigenetics
C Lu, CB Thompson
Cell Metabolism 16 (1), 9-17, 2012
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
KE Wellen, C Lu, A Mancuso, JMS Lemons, M Ryczko, JW Dennis, ...
Genes & development 24 (24), 2784-2799, 2010
Therapeutic targets in cancer cell metabolism and autophagy
H Cheong, C Lu, T Lindsten, CB Thompson
Nature Biotechnology 30 (7), 671-678, 2012
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
H Cheong, T Lindsten, J Wu, C Lu, CB Thompson
Proceedings of the National Academy of Sciences 108 (27), 11121, 2011
Hypoxia induces production of L-2-hydroxyglutarate
AM Intlekofer, RG Dematteo, S Venneti, LWS Finley, C Lu, AR Judkins, ...
Cell metabolism 22 (2), 304-311, 2015
Serine catabolism regulates mitochondrial redox control during hypoxia
J Ye, J Fan, S Venneti, YW Wan, BR Pawel, J Zhang, LWS Finley, C Lu, ...
Cancer discovery 4 (12), 1406-1417, 2014
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ...
Cell reports 9 (5), 1841-1855, 2014
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ...
Genes & Development 27 (18), 1974-1985, 2013
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
C Lu, SU Jain, D Hoelper, D Bechet, RC Molden, L Ran, D Murphy, ...
Science 352 (6287), 844-849, 2016
Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
PS Ward, JR Cross, C Lu, O Weigert, O Abel-Wahab, RL Levine, ...
Oncogene, 2011
Targeting p53 for enhanced radio-and chemo-sensitivity
C Lu, WS El-Deiry
Apoptosis 14 (4), 597-606, 2009
Induction of sarcomas by mutant IDH2
C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ...
Genes & Development 27 (18), 1986-1998, 2013
The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
PS Ward, C Lu, JR Cross, O Abdel-Wahab, RL Levine, GK Schwartz, ...
Journal of Biological Chemistry 288 (6), 3804-3815, 2013
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
S Papillon-Cavanagh, C Lu, T Gayden, LG Mikael, D Bechet, ...
Nature genetics 49 (2), 180, 2017
Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas
D Bechet, GGH Gielen, A Korshunov, SM Pfister, C Rousso, D Faury, ...
Acta neuropathologica 128 (5), 733-741, 2014
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction
D Zhang, C Lu, M Whiteman, B Chance, JS Armstrong
Journal of Biological Chemistry 283 (6), 3476-3486, 2008
DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation
TL Gentile, C Lu, PM Lodato, S Tse, SH Olejniczak, ES Witze, ...
Molecular and cellular biology 33 (19), 3864-3878, 2013
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