| Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer H Chen, J Yao, R Bao, Y Dong, T Zhang, Y Du, G Wang, D Ni, Z Xun, ... Molecular cancer 20, 1-21, 2021 | 146 | 2021 |
| Allosteric modulator discovery: from serendipity to structure-based design S Lu, X He, D Ni, J Zhang Journal of medicinal chemistry 62 (14), 6405-6421, 2019 | 135 | 2019 |
| Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design S Lu, X He, Z Yang, Z Chai, S Zhou, J Wang, AU Rehman, D Ni, J Pu, ... Nature Communications 12 (1), 4721, 2021 | 129 | 2021 |
| Discovery of hidden allosteric sites as novel targets for allosteric drug design S Lu, M Ji, D Ni, J Zhang Drug discovery today 23 (2), 359-365, 2018 | 99 | 2018 |
| Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy D Ni, J Wei, X He, AU Rehman, X Li, Y Qiu, J Pu, S Lu, J Zhang Chemical science 12 (1), 464-476, 2021 | 90 | 2021 |
| Rational design of peptide-based inhibitors disrupting protein-protein interactions X Wang, D Ni, Y Liu, S Lu Frontiers in Chemistry 9, 682675, 2021 | 86 | 2021 |
| Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery D Ni, S Lu, J Zhang Medicinal research reviews 39 (6), 2314-2342, 2019 | 85 | 2019 |
| AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses M Huang, K Song, X Liu, S Lu, Q Shen, R Wang, J Gao, Y Hong, Q Li, ... Nucleic acids research 46 (W1), W451-W458, 2018 | 81 | 2018 |
| Deactivation pathway of Ras GTPase underlies conformational substates as targets for drug design S Lu, D Ni, C Wang, X He, H Lin, Z Wang, J Zhang ACS Catalysis 9 (8), 7188-7196, 2019 | 78 | 2019 |
| Drugging K-RasG12C through covalent inhibitors: mission possible? D Ni, X Li, X He, H Zhang, J Zhang, S Lu Pharmacology & therapeutics 202, 1-17, 2019 | 74 | 2019 |
| Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery S Lu, Y Qiu, D Ni, X He, J Pu, J Zhang Drug discovery today 25 (1), 177-184, 2020 | 72 | 2020 |
| Combining allosteric and orthosteric drugs to overcome drug resistance D Ni, Y Li, Y Qiu, J Pu, S Lu, J Zhang Trends in pharmacological sciences 41 (5), 336-348, 2020 | 67 | 2020 |
| Unraveling allosteric landscapes of allosterome with ASD X Liu, S Lu, K Song, Q Shen, D Ni, Q Li, X He, H Zhang, Q Wang, Y Chen, ... Nucleic acids research 48 (D1), D394-D401, 2020 | 62 | 2020 |
| Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators S Lu, Y Chen, J Wei, M Zhao, D Ni, X He, J Zhang Acta Pharmaceutica Sinica B 11 (5), 1355-1361, 2021 | 57 | 2021 |
| Gut-derived acetate promotes B10 cells with antiinflammatory effects CI Daïen, J Tan, R Audo, J Mielle, LE Quek, JR Krycer, A Angelatos, ... JCI insight 6 (7), 2021 | 52 | 2021 |
| Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins Y Wang, D Ji, C Lei, Y Chen, Y Qiu, X Li, M Li, D Ni, J Pu, J Zhang, Q Fu, ... Computational and structural biotechnology journal 19, 1184-1199, 2021 | 52 | 2021 |
| PLX5622 reduces disease severity in lethal CNS infection by off-target inhibition of peripheral inflammatory monocyte production AG Spiteri, D Ni, ZL Ling, L Macia, IL Campbell, MJ Hofer, NJC King Frontiers in Immunology 13, 851556, 2022 | 42 | 2022 |
| Along the allostery stream: Recent advances in computational methods for allosteric drug discovery D Ni, Z Chai, Y Wang, M Li, Z Yu, Y Liu, S Lu, J Zhang Wiley Interdisciplinary Reviews: Computational Molecular Science 12 (4), e1585, 2022 | 38 | 2022 |
| Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B X Li, J Dai, D Ni, X He, H Zhang, J Zhang, Q Fu, Y Liu, S Lu International Journal of Biological Macromolecules 144, 643-655, 2020 | 37 | 2020 |
| Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells Q Zhang, Y Chen, D Ni, Z Huang, J Wei, L Feng, JC Su, Y Wei, S Ning, ... Acta Pharmaceutica Sinica B 12 (2), 876-889, 2022 | 35 | 2022 |
Jian ZhangShanghai Jiaotong University School of MedicineVerified email at sjtu.edu.cn
