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Ewan Smith
Ewan Smith
Postdoctoral researcher, Beatson Institute
Adresse e-mail validée de beatson.gla.ac.uk
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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
EM Smith, SG Finn, AR Tee, GJ Browne, CG Proud
Journal of Biological Chemistry 280 (19), 18717-18727, 2005
4732005
Regulation of miRNA strand selection: follow the leader?
HA Meijer, EM Smith, M Bushell
Biochemical Society Transactions 42 (4), 1135-1140, 2014
3092014
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud
Journal of Biological Chemistry 282 (34), 24514-24524, 2007
2952007
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice
M Halliday, H Radford, KAM Zents, C Molloy, JA Moreno, NC Verity, ...
Brain 140 (6), 1768-1783, 2017
2812017
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
2612015
Drosha drives the formation of DNA: RNA hybrids around DNA break sites to facilitate DNA repair
WT Lu, BR Hawley, GL Skalka, RA Baldock, EM Smith, AS Bader, ...
Nature communications 9 (1), 532, 2018
1982018
The ever-evolving role of mTOR in translation
BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause
Seminars in cell & developmental biology 36, 102-112, 2014
1262014
Differential control of Eg5‐dependent centrosome separation by Plk1 and Cdk1
E Smith, N Hégarat, C Vesely, I Roseboom, C Larch, H Streicher, ...
The EMBO journal 30 (11), 2233-2245, 2011
1252011
cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle‐and amino acid‐dependent manner
EM Smith, CG Proud
The EMBO journal 27 (7), 1005-1016, 2008
1162008
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics
N Hégarat, E Smith, G Nayak, S Takeda, PA Eyers, H Hochegger
Journal of Cell Biology 195 (7), 1103-1113, 2011
862011
The diverse roles of the eIF4A family: you are the company you keep
WT Lu, A Wilczynska, E Smith, M Bushell
Biochemical Society Transactions 42 (1), 166-172, 2014
742014
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ...
Nucleic acids research 49 (6), 3461-3489, 2021
612021
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase
S Pyr Dit Ruys, X Wang, EM Smith, G Herinckx, N Hussain, MH Rider, ...
Biochemical Journal 442 (3), 681-692, 2012
542012
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ...
Cancer discovery 11 (5), 1228-1247, 2021
532021
Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase
JH Chen, M Riazy, EM Smith, CG Proud, UP Steinbrecher, V Duronio
Arteriosclerosis, thrombosis, and vascular biology 29 (1), 92-98, 2009
492009
Centrosome amplification in CHO and DT40 cells by inactivation of cyclin‐dependent kinases
N Steere, M Wagner, S Beishir, E Smith, L Breslin, CG Morrison, ...
Cytoskeleton 68 (8), 446-458, 2011
322011
Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells
WR Wan Makhtar, G Browne, A Karountzos, C Stevens, Y Alghamdi, ...
Oncogene 36 (47), 6640-6648, 2017
252017
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction
EM Smith, NEH Benbahouche, K Morris, A Wilczynska, S Gillen, ...
Nucleic acids research 49 (1), 458-478, 2021
232021
LARP1 is a major phosphorylation substrate of mTORC1
BD Fonseca, JJ Jia, AK Hollensen, R Pointet, HD Hoang, MR Niklaus, ...
BioRxiv, 491274, 2018
152018
Parallel evolution of semicircular canal form and sensitivity in subterranean mammals
J Goyens, S Baeckens, ESJ Smith, J Pozzi, MJ Mason
Journal of Comparative Physiology A 208 (5), 627-640, 2022
22022
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