Philipp F. Lange

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Christopher M OverallUniversity of British ColumbiaVerified email at ubc.ca
Pitter F. HuesgenUniversity of Freiburg, CIBSS - Centre for Integrative Biological Signalling StudiesVerified email at biologie.uni-freiburg.de
Reinhild KappelhoffResearch Associate & Labmanager, Centre for Blood Research, Faculty of Dentistry, University of BCVerified email at ubc.ca
Ulrich auf dem KellerTechnical University of DenmarkVerified email at dtu.dk
Amanda E. StarrScientific EvaluatorVerified email at canada.ca
Ulrich Eckhard (ORCID:0000-0001-58...Group Leader, Department of Structural and Molecular Biology, IBMB-CSIC (ROR:05t8khn72)Verified email at ibmb.csic.es
Georgina S. ButlerResearch Associate, Center for Blood Research, University of British Columbia, Canada.Verified email at ubc.ca
Chris A. MaxwellProfessor, University of British Columbia; Investigator, BC Children's Hospital ResearchVerified email at bcchr.ubc.ca
Chinten James LimUniversity of British ColumbiaVerified email at mail.ubc.ca
Nikolaus FortelnyUniversity of SalzburgVerified email at plus.ac.at
Antoine DufourAssociate Professsor, University of CalgaryVerified email at ucalgary.ca
Paul PavlidisProfessor of Psychiatry, University of British ColumbiaVerified email at msl.ubc.ca
Oliver SchillingUniversity of FreiburgVerified email at mol-med.uni-freiburg.de
Theo KleinNetherlands Forensics Institute NFIVerified email at nfi.nl
Richard TingWeill Cornell Medicine, Department of RadiologyVerified email at med.cornell.edu
François BénardProfessor of Radiology, University of British ColumbiaVerified email at bccrc.ca
F. Xavier Gomis-RüthFull Professor CSICVerified email at ibmb.csic.es
Vasilena GochevaKoch Institute for Integrative Cancer Research at MITVerified email at mit.edu
Johanna JoyceUniversity of LausanneVerified email at unil.ch
Wolfgang P. SchröderBiokemi, Umeå UniversityVerified email at chem.umu.se

Philipp F. Lange

Canada Research Chair & Associate Professor of Pathology, University of British Columbia

Verified email at ubc.ca - Homepage

cancer proteomics post_translational_modifications systems_biology protease


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ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function PF Lange, L Wartosch, TJ Jentsch, JC Fuhrmann Nature 440 (7081), 220-223, 2006	390	2006
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic … U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Matrix biology 49, 37-60, 2016	230	2016
Network analyses reveal pervasive functional regulation between proteases in the human protease web N Fortelny, JH Cox, R Kappelhoff, AE Starr, PF Lange, P Pavlidis, ... PLoS biology 12 (5), e1001869, 2014	184	2014
LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification PF Huesgen, PF Lange, LD Rogers, N Solis, U Eckhard, O Kleifeld, ... Nature methods 12 (1), 55-58, 2015	161	2015
Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre-and post-translational events N Fortelny, S Yang, P Pavlidis, PF Lange, CM Overall Nucleic acids research 43 (D1), D290-D297, 2015	136	2015
Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis CL Bellac, A Dufour, MJ Krisinger, A Loonchanta, AE Starr, ... Cell Reports 9 (2), 618-632, 2014	110	2014
Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human … PF Lange, PF Huesgen, K Nguyen, CM Overall Journal of proteome research 13 (4), 2028-2044, 2014	110	2014
TopFIND, a knowledgebase linking protein termini with function PF Lange, CM Overall Nature methods 8 (9), 703-704, 2011	102	2011
Protein TAILS: when termini tell tales of proteolysis and function PF Lange, CM Overall Current Opinion in Chemical Biology 17 (1), 73-82, 2013	101	2013
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples SSH Weng, F Demir, EK Ergin, S Dirnberger, A Uzozie, D Tuscher, ... Molecular & Cellular Proteomics 18 (11), 2335-2347, 2019	93	2019
Novel matrix metalloproteinase inhibitor [18F] marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer U auf dem Keller, CL Bellac, Y Li, Y Lou, PF Lange, R Ting, C Harwig, ... Cancer research 70 (19), 7562-7569, 2010	86	2010
TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors A Prudova, V Gocheva, U Auf dem Keller, U Eckhard, OC Olson, L Akkari, ... Cell reports 16 (6), 1762-1773, 2016	82	2016
TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein function PF Lange, PF Huesgen, CM Overall Nucleic acids research 40 (D1), D351-D361, 2012	61	2012
Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids PF Huesgen, M Alami, PF Lange, LJ Foster, WP Schröder, CM Overall, ... PloS one 8 (9), e74483, 2013	59	2013
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development M Connell, H Chen, J Jiang, CW Kuan, A Fotovati, TLH Chu, Z He, ... Elife 6, e28672, 2017	56	2017
Towards kit-like 18 F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases Y Li, R Ting, CW Harwig, U auf dem Keller, CL Bellac, PF Lange, ... MedChemComm 2 (10), 942-949, 2011	50	2011
Modification of BRCA1-associated breast cancer risk by HMMR overexpression F Mateo, Z He, L Mei, GR de Garibay, C Herranz, N García, A Lorentzian, ... Nature communications 13 (1), 1895, 2022	38	2022
Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease PF Huesgen, PF Lange, CM Overall PROTEOMICS–Clinical Applications 8 (5-6), 338-350, 2014	35	2014
Fold-change compression: an unexplored but correctable quantitative bias caused by nonlinear electrospray ionization responses in untargeted metabolomics H Yu, S Xing, L Nierves, PF Lange, T Huan Analytical chemistry 92 (10), 7011-7019, 2020	32	2020
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14 U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Data in brief 7, 299-310, 2016	29	2016

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