Philipp F. Lange
Philipp F. Lange
Canada Research Chair & Associate Professor of Pathology, University of British Columbia
Verified email at - Homepage
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Cited by
ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function
PF Lange, L Wartosch, TJ Jentsch, JC Fuhrmann
Nature 440 (7081), 220-223, 2006
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic …
U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ...
Matrix biology 49, 37-60, 2016
Network analyses reveal pervasive functional regulation between proteases in the human protease web
N Fortelny, JH Cox, R Kappelhoff, AE Starr, PF Lange, P Pavlidis, ...
PLoS biology 12 (5), e1001869, 2014
LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification
PF Huesgen, PF Lange, LD Rogers, N Solis, U Eckhard, O Kleifeld, ...
Nature methods 12 (1), 55-58, 2015
Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre-and post-translational events
N Fortelny, S Yang, P Pavlidis, PF Lange, CM Overall
Nucleic acids research 43 (D1), D290-D297, 2015
Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human …
PF Lange, PF Huesgen, K Nguyen, CM Overall
Journal of proteome research 13 (4), 2028-2044, 2014
Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis
CL Bellac, A Dufour, MJ Krisinger, A Loonchanta, AE Starr, ...
Cell Reports 9 (2), 618-632, 2014
TopFIND, a knowledgebase linking protein termini with function
PF Lange, CM Overall
Nature methods 8 (9), 703-704, 2011
Protein TAILS: when termini tell tales of proteolysis and function
PF Lange, CM Overall
Current Opinion in Chemical Biology 17 (1), 73-82, 2013
Novel matrix metalloproteinase inhibitor [18F] marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer
U auf dem Keller, CL Bellac, Y Li, Y Lou, PF Lange, R Ting, C Harwig, ...
Cancer research 70 (19), 7562-7569, 2010
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples
SSH Weng, F Demir, EK Ergin, S Dirnberger, A Uzozie, D Tuscher, ...
Molecular & Cellular Proteomics 18 (11), 2335-2347, 2019
TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors
A Prudova, V Gocheva, U Auf dem Keller, U Eckhard, OC Olson, L Akkari, ...
Cell reports 16 (6), 1762-1773, 2016
TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein function
PF Lange, PF Huesgen, CM Overall
Nucleic acids research 40 (D1), D351-D361, 2012
Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids
PF Huesgen, M Alami, PF Lange, LJ Foster, WP Schröder, CM Overall, ...
PloS one 8 (9), e74483, 2013
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development
M Connell, H Chen, J Jiang, CW Kuan, A Fotovati, TLH Chu, Z He, ...
Elife 6, e28672, 2017
Towards kit-like 18 F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases
Y Li, R Ting, CW Harwig, U auf dem Keller, CL Bellac, PF Lange, ...
MedChemComm 2 (10), 942-949, 2011
Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease
PF Huesgen, PF Lange, CM Overall
PROTEOMICS–Clinical Applications 8 (5-6), 338-350, 2014
Fold-change compression: an unexplored but correctable quantitative bias caused by nonlinear electrospray ionization responses in untargeted metabolomics
H Yu, S Xing, L Nierves, PF Lange, T Huan
Analytical chemistry 92 (10), 7011-7019, 2020
Modification of BRCA1-associated breast cancer risk by HMMR overexpression
F Mateo, Z He, L Mei, GR de Garibay, C Herranz, N García, A Lorentzian, ...
Nature communications 13 (1), 1895, 2022
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14
U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ...
Data in brief 7, 299-310, 2016
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