| Structural insights into the polymorphism of amyloid-like fibrils formed by region 20− 29 of amylin revealed by solid-state NMR and X-ray fiber diffraction J Madine, E Jack, PG Stockley, SE Radford, LC Serpell, DA Middleton Journal of the American Chemical Society 130 (45), 14990-15001, 2008 | 216 | 2008 |
| Design of an N-methylated peptide inhibitor of α-synuclein aggregation guided by solid-state NMR J Madine, AJ Doig, DA Middleton Journal of the American Chemical Society 130 (25), 7873-7881, 2008 | 114 | 2008 |
| A study of the regional effects of α-synuclein on the organization and stability of phospholipid bilayers J Madine, AJ Doig, DA Middleton Biochemistry 45 (18), 5783-5792, 2006 | 78 | 2006 |
| Inhibitors of protein aggregation and toxicity H Amijee, J Madine, DA Middleton, AJ Doig Biochemical Society Transactions 37 (4), 692-696, 2009 | 75 | 2009 |
| Insights into the molecular architecture of a peptide nanotube using FTIR and solid‐state NMR spectroscopic measurements on an aligned sample DA Middleton, J Madine, V Castelletto, IW Hamley Angewandte Chemie International Edition 52 (40), 10537-10540, 2013 | 70 | 2013 |
| Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease J Wagner, K Degenhardt, M Veit, N Louros, K Konstantoulea, A Skodras, ... Nature 612 (7938), 123-131, 2022 | 47 | 2022 |
| Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts RQ Migrino, HA Davies, S Truran, N Karamanova, DA Franco, TG Beach, ... Cardiovascular research 113 (11), 1389-1402, 2017 | 44 | 2017 |
| Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks J Madine, HA Davies, C Shaw, IW Hamley, DA Middleton Chemical communications 48 (24), 2976-2978, 2012 | 38 | 2012 |
| The effects of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy J Madine, E Hughes, AJ Doig, DA Middleton Molecular Membrane Biology 25 (6-7), 518-527, 2008 | 38 | 2008 |
| Site‐specific identification of an Aβ fibril–heparin interaction site by using solid‐state NMR spectroscopy J Madine, MJ Pandya, MR Hicks, A Rodger, EA Yates, SE Radford, ... Angewandte Chemie 124 (52), 13317-13320, 2012 | 35 | 2012 |
| Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin J Madine, DA Middleton European Biophysics Journal 39, 1281-1288, 2010 | 33 | 2010 |
| Heparin and methionine oxidation promote the formation of apolipoprotein AI amyloid comprising α-helical and β-sheet structures D Townsend, E Hughes, R Hussain, G Siligardi, S Baldock, J Madine, ... Biochemistry 56 (11), 1632-1644, 2017 | 30 | 2017 |
| Cross-β spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements J Madine, A Copland, LC Serpell, DA Middleton Biochemistry 48 (14), 3089-3099, 2009 | 29 | 2009 |
| Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice K Degenhardt, J Wagner, A Skodras, M Candlish, AJ Koppelmann, K Wild, ... Proceedings of the National Academy of Sciences 117 (38), 23925-23931, 2020 | 27 | 2020 |
| Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity J Madine, HA Davies, E Hughes, DA Middleton Biochemistry 52 (50), 8984-8992, 2013 | 25 | 2013 |
| Endothelial immune activation by medin: potential role in cerebrovascular disease and reversal by monosialoganglioside‐containing nanoliposomes N Karamanova, S Truran, GE Serrano, TG Beach, J Madine, V Weissig, ... Journal of the American Heart Association 9 (2), e014810, 2020 | 23 | 2020 |
| Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia RQ Migrino, N Karamanova, S Truran, GE Serrano, HA Davies, J Madine, ... Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 12 (1 …, 2020 | 23 | 2020 |
| Oxidative stress alters the morphology and toxicity of aortic medial amyloid HA Davies, MM Phelan, MC Wilkinson, RQ Migrino, S Truran, DA Franco, ... Biophysical Journal 109 (11), 2363-2370, 2015 | 22 | 2015 |
| Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation YH Chim, HA Davies, D Mason, O Nawaytou, M Field, J Madine, R Akhtar The Journal of Thoracic and Cardiovascular Surgery 160 (6), e239-e257, 2020 | 21 | 2020 |
| Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein MM Phelan, E Caamaño-Gutiérrez, MS Gant, RX Grosman, J Madine Metabolomics 13, 1-13, 2017 | 20 | 2017 |
