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Kenneth Lum
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Proteome-wide covalent ligand discovery in native biological systems
KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ...
Nature 534 (7608), 570-574, 2016
7202016
An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers
GR Villa, JJ Hulce, C Zanca, J Bi, S Ikegami, GL Cahill, Y Gu, KM Lum, ...
Cancer cell 30 (5), 683-693, 2016
2742016
An activity-guided map of electrophile-cysteine interactions in primary human T cells
EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ...
Cell 182 (4), 1009-1026. e29, 2020
2142020
A global map of lipid-binding proteins and their ligandability in cells
MJ Niphakis, KM Lum, AB Cognetta, BE Correia, TA Ichu, J Olucha, ...
Cell 161 (7), 1668-1680, 2015
2132015
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates
JW Chang, MJ Niphakis, KM Lum, AB Cognetta, C Wang, ML Matthews, ...
Chemistry & biology 19 (5), 579-588, 2012
2122012
Chemical proteomic profiling of human methyltransferases
BD Horning, RM Suciu, DA Ghadiri, OA Ulanovskaya, ML Matthews, ...
Journal of the American Chemical Society 138 (40), 13335-13343, 2016
892016
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan, AJ Firestone, ...
Nature chemical biology 17 (8), 856-864, 2021
502021
Single-cell profiling and SCOPE-Seq reveal lineage dynamics of adult ventricular-subventricular zone neurogenesis and NOTUM as a key regulator
D Mizrak, NS Bayin, J Yuan, Z Liu, RM Suciu, MJ Niphakis, N Ngo, ...
Cell reports 31 (12), 2020
482020
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
J Tan, AB Cognetta III, DB Diaz, KM Lum, S Adachi, S Kundu, BF Cravatt, ...
Nature communications 8 (1), 1760, 2017
472017
Carbamate compounds and of making and using same
JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ...
US Patent 9,133,148, 2015
422015
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan
AL Chen, KM Lum, P Lara-Gonzalez, D Ogasawara, AB Cognetta III, A To, ...
Nature chemical biology 15 (5), 453-462, 2019
392019
Carbamate compounds and of making and using same
JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ...
US Patent 9,487,495, 2016
362016
Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors
BW Zaro, LR Whitby, KM Lum, BF Cravatt
Journal of the American Chemical Society 138 (49), 15841-15844, 2016
342016
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice
ME Ertunc, BP Kok, WH Parsons, JG Wang, D Tan, CJ Donaldson, ...
Journal of Biological Chemistry 295 (18), 5891-5905, 2020
312020
Mapping protein targets of bioactive small molecules using lipid-based chemical proteomics
KM Lum, Y Sato, BA Beyer, WC Plaisted, JL Anglin, LL Lairson, ...
ACS chemical biology 12 (10), 2671-2681, 2017
292017
Stabilized Wittig olefination for bioconjugation
KM Lum, VJ Xavier, MJH Ong, CW Johannes, KP Chan
Chemical communications 49 (95), 11188-11190, 2013
252013
Carbamate compounds and methods of making and using same
JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ...
US Patent 9,957,242, 2018
142018
3-Oxo-β-sultam as a sulfonylating chemotype for inhibition of serine hydrolases and activity-based protein profiling
LAR Carvalho, VT Almeida, JA Brito, KM Lum, TF Oliveira, RC Guedes, ...
ACS Chemical Biology 15 (4), 878-883, 2020
102020
Carbamate compounds and methods of making and using same
JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ...
US Patent App. 15/925,517, 2018
102018
Chemoproteomik‐basierte Identifikation von 4‐Oxo‐β‐lactamen als Inhibitoren der Dipeptidylpeptidasen 8 und 9
LAR Carvalho, B Ross, L Fehr, O Bolgi, S Wöhrle, KM Lum, ...
Angewandte Chemie 134 (47), e202210498, 2022
72022
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Articles 1–20