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Hilal Lashuel
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The many faces of α-synuclein: from structure and toxicity to therapeutic target
HA Lashuel, CR Overk, A Oueslati, E Masliah
Nature Reviews Neuroscience 14 (1), 38-48, 2013
16972013
Amyloid pores from pathogenic mutations
HA Lashuel, D Hartley, BM Petre, T Walz, PT Lansbury Jr
Nature 418 (6895), 291-291, 2002
16122002
The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
Y Liu, L Fallon, HA Lashuel, Z Liu, PT Lansbury
Cell 111 (2), 209-218, 2002
10732002
α-Synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
HA Lashuel, BM Petre, J Wall, M Simon, RJ Nowak, T Walz, ...
Journal of molecular biology 322 (5), 1089-1102, 2002
10512002
A century-old debate on protein aggregation and neurodegeneration enters the clinic
PT Lansbury, HA Lashuel
Nature 443 (7113), 774-779, 2006
8052006
Amyloidogenic protein–membrane interactions: mechanistic insight from model systems
SM Butterfield, HA Lashuel
Angewandte Chemie International Edition 49 (33), 5628-5654, 2010
6812010
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
B Fauvet, MK Mbefo, MB Fares, C Desobry, S Michael, MT Ardah, E Tsika, ...
Journal of Biological Chemistry 287 (19), 15345-15364, 2012
6472012
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
AL Mahul-Mellier, J Burtscher, N Maharjan, L Weerens, M Croisier, ...
Proceedings of the National Academy of Sciences 117 (9), 4971-4982, 2020
5252020
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
HA Lashuel, PT Lansbury
Quarterly reviews of biophysics 39 (2), 167-201, 2006
5022006
Inhibiting transthyretin amyloid fibril formation via protein stabilization
GJ Miroy, Z Lai, HA Lashuel, SA Peterson, C Strang, JW Kelly
Proceedings of the National Academy of Sciences 93 (26), 15051-15056, 1996
4411996
Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: implications for Parkinson’s disease pathogenesis and therapies
A Oueslati, M Fournier, HA Lashuel
Progress in brain research 183, 115-145, 2010
4322010
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein
KE Paleologou, AW Schmid, CC Rospigliosi, HY Kim, GR Lamberto, ...
Journal of Biological Chemistry 283 (24), 16895-16905, 2008
4232008
Half a century of amyloids: past, present and future
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, ...
Chemical Society Reviews 49 (15), 5473-5509, 2020
3882020
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
KE Paleologou, A Oueslati, G Shakked, CC Rospigliosi, HY Kim, ...
Journal of Neuroscience 30 (9), 3184-3198, 2010
3872010
Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science
HA Lashuel, SR LaBrenz, L Woo, LC Serpell, JW Kelly
Journal of the American Chemical Society 122 (22), 5262-5277, 2000
3492000
Amyloid-β aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability
I Allaman, M Gavillet, M Bélanger, T Laroche, D Viertl, HA Lashuel, ...
Journal of Neuroscience 30 (9), 3326-3338, 2010
3202010
The ratio of monomeric to aggregated forms of Aβ40 and Aβ42 is an important determinant of amyloid-β aggregation, fibrillogenesis, and toxicity
A Jan, O Gokce, R Luthi-Carter, HA Lashuel
Journal of Biological Chemistry 283 (42), 28176-28189, 2008
3162008
Mixtures of wild-type and a pathogenic (E22G) form of Aβ40 in vitro accumulate protofibrils, including amyloid pores
HA Lashuel, DM Hartley, BM Petre, JS Wall, MN Simon, T Walz, ...
Journal of molecular biology 332 (4), 795-808, 2003
3092003
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
Y Liu, HA Lashuel, S Choi, X Xing, A Case, J Ni, LA Yeh, GD Cuny, ...
Chemistry & biology 10 (9), 837-846, 2003
3082003
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions
T Nakagawa, K Futai, HA Lashuel, I Lo, K Okamoto, T Walz, Y Hayashi, ...
Neuron 44 (3), 453-467, 2004
2952004
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Articles 1–20