| Normal growth and development in the absence of hepatic insulin-like growth factor I S Yakar, JL Liu, B Stannard, A Butler, D Accili, B Sauer, D LeRoith Proceedings of the National Academy of Sciences 96 (13), 7324-7329, 1999 | 1730 | 1999 |
| The somatomedin hypothesis: 2001 D Le Roith, C Bondy, S Yakar, JL Liu, A Butler Endocrine reviews 22 (1), 53-74, 2001 | 1707 | 2001 |
| The role of the IGF system in cancer growth and metastasis: overview and recent insights AA Samani, S Yakar, D LeRoith, P Brodt Endocrine reviews 28 (1), 20-47, 2007 | 1339 | 2007 |
| Circulating levels of IGF-1 directly regulate bone growth and density S Yakar, CJ Rosen, WG Beamer, CL Ackert-Bicknell, Y Wu, JL Liu, GT Ooi, ... The Journal of clinical investigation 110 (6), 771-781, 2002 | 1167 | 2002 |
| Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells L Xian, X Wu, L Pang, M Lou, CJ Rosen, T Qiu, J Crane, F Frassica, ... Nature medicine 18 (7), 1095-1101, 2012 | 625 | 2012 |
| Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis Y Wu, S Yakar, L Zhao, L Hennighausen, D LeRoith Cancer research 62 (4), 1030-1035, 2002 | 539 | 2002 |
| Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity S Yakar, JL Liu, AM Fernandez, Y Wu, AV Schally, J Frystyk, ... Diabetes 50 (5), 1110-1118, 2001 | 466 | 2001 |
| Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes AM Fernández, JK Kim, S Yakar, J Dupont, C Hernandez-Sanchez, ... Genes & development 15 (15), 1926-1934, 2001 | 439 | 2001 |
| Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1 D LeRoith, S Yakar Nature clinical practice Endocrinology & metabolism 3 (3), 302-310, 2007 | 372 | 2007 |
| Biological effects of growth hormone on carbohydrate and lipid metabolism A Vijayakumar, R Novosyadlyy, YJ Wu, S Yakar, D LeRoith Growth Hormone & IGF Research 20 (1), 1-7, 2010 | 368 | 2010 |
| Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology AA Butler, S Yakar, IH Gewolb, M Karas, Y Okubo, D LeRoith Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular …, 1998 | 355 | 1998 |
| Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes R Novosyadlyy, DE Lann, A Vijayakumar, A Rowzee, DA Lazzarino, ... Cancer research 70 (2), 741-751, 2010 | 326 | 2010 |
| Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice S Yakar, J Setser, H Zhao, B Stannard, M Haluzik, V Glatt, ML Bouxsein, ... The Journal of clinical investigation 113 (1), 96-105, 2004 | 312 | 2004 |
| Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors Y Wu, K Cui, K Miyoshi, L Hennighausen, JE Green, J Setser, D LeRoith, ... Cancer research 63 (15), 4384-4388, 2003 | 277 | 2003 |
| The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models S Yakar, D LeRoith, P Brodt Cytokine & growth factor reviews 16 (4-5), 407-420, 2005 | 261 | 2005 |
| Peroxisome proliferator–activated receptor-α agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis H Kim, M Haluzik, Z Asghar, D Yau, JW Joseph, AM Fernandez, ... Diabetes 52 (7), 1770-1778, 2003 | 217 | 2003 |
| Increased P85α is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess LA Barbour, SM Rahman, I Gurevich, JW Leitner, SJ Fischer, MD Roper, ... Journal of Biological Chemistry 280 (45), 37489-37494, 2005 | 204 | 2005 |
| 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton S Yakar, H Werner, CJ Rosen Journal of molecular endocrinology 61 (1), T115-T137, 2018 | 198 | 2018 |
| PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells H Zhao, J Dupont, S Yakar, M Karas, D LeRoith Oncogene 23 (3), 786-794, 2004 | 197 | 2004 |
| The intricate role of growth hormone in metabolism A Vijayakumar, S Yakar, D LeRoith Frontiers in endocrinology 2, 32, 2011 | 184 | 2011 |
