| Thiyl radicals in ribonucleotide reductases S Licht, GJ Gerfen, JA Stubbe Science 271 (5248), 477-481, 1996 | 406 | 1996 |
| Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction S Booker, S Licht, J Broderick, J Stubbe Biochemistry 33 (42), 12676-12685, 1994 | 151 | 1994 |
| Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule G Deng, J Shen, M Yin, J McManus, M Mathieu, P Gee, T He, C Shi, ... Journal of Biological Chemistry 290 (2), 762-774, 2015 | 141 | 2015 |
| Electron paramagnetic resonance investigations of a kinetically competent intermediate formed in ribonucleotide reduction: Evidence for a thiyl radical-cob (II) alamin interaction GJ Gerfen, S Licht, JP Willems, BM Hoffman, J Stubbe Journal of the American Chemical Society 118 (35), 8192-8197, 1996 | 124 | 1996 |
| Studies on the catalysis of carbon− cobalt bond homolysis by ribonucleoside triphosphate reductase: Evidence for concerted carbon− cobalt bond homolysis and thiyl radical formation SS Licht, S Booker, JA Stubbe Biochemistry 38 (4), 1221-1233, 1999 | 105 | 1999 |
| Dependence on the pyrimidine biosynthetic enzyme DHODH is a synthetic lethal vulnerability in mutant KRAS-driven cancers M Koundinya, J Sudhalter, A Courjaud, B Lionne, G Touyer, L Bonnet, ... Cell chemical biology 25 (6), 705-717. e11, 2018 | 86 | 2018 |
| Mechanistic investigations of ribonucleotide reductases S Licht, J Stubbe Pergamon, 1999 | 78 | 1999 |
| Thermodynamic and kinetic studies on carbon− cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis SS Licht, CC Lawrence, JA Stubbe Biochemistry 38 (4), 1234-1242, 1999 | 75 | 1999 |
| Control of peptide product sizes by the energy-dependent protease ClpAP KH Choi, S Licht Biochemistry 44 (42), 13921-13931, 2005 | 66 | 2005 |
| ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysis LD Jennings, DS Lun, M Médard, S Licht Biochemistry 47 (44), 11536-11546, 2008 | 60 | 2008 |
| An activity-based protein profiling probe for the nicotinic acetylcholine receptor M Tantama, WC Lin, S Licht Journal of the American Chemical Society 130 (47), 15766-15767, 2008 | 56 | 2008 |
| The ClpP N-terminus coordinates substrate access with protease active site reactivity LD Jennings, J Bohon, MR Chance, S Licht Biochemistry 47 (42), 11031-11040, 2008 | 49 | 2008 |
| Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop J Bohon, LD Jennings, CM Phillips, S Licht, MR Chance Structure 16 (8), 1157-1165, 2008 | 49 | 2008 |
| Class II Ribonucleotide Reductases Catalyze Carbon− Cobalt Bond Reformation on Every Turnover SS Licht, CC Lawrence, JA Stubbe Journal of the American Chemical Society 121 (33), 7463-7468, 1999 | 40 | 1999 |
| Resolving individual steps in the operation of ATP-dependent proteolytic molecular machines: from conformational changes to substrate translocation and processivity S Licht, I Lee Biochemistry 47 (12), 3595-3605, 2008 | 38 | 2008 |
| A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis SS Licht, A Sonnleitner, S Weiss, PG Schultz Biochemistry 42 (10), 2916-2925, 2003 | 32 | 2003 |
| Therapeutic enzyme engineering using a generative neural network A Giessel, A Dousis, K Ravichandran, K Smith, S Sur, I McFadyen, ... Scientific Reports 12 (1), 1536, 2022 | 29 | 2022 |
| Plasticity of acetylcholine receptor gating motions via rate-energy relationships A Mitra, R Tascione, A Auerbach, S Licht Biophysical journal 89 (5), 3071-3078, 2005 | 21 | 2005 |
| Abstract A226: Mechanism of action of iniparib: Stimulation of reactive oxygen species (ROS) production in an iniparib-sensitive breast cancer cell line. S Licht, H Cao, Z Li, J Zhang, F Liu, S Brittain, J Shen, B Zhang, J Hopke, ... Molecular Cancer Therapeutics 10 (11_Supplement), A226-A226, 2011 | 20 | 2011 |
| Role of a conserved pore residue in the formation of a prehydrolytic high substrate affinity state in the AAA+ chaperone ClpA ME Farbman, A Gershenson, S Licht Biochemistry 47 (51), 13497-13505, 2008 | 18 | 2008 |
Muriel MedardProfessor of EECS, MITVerified email at mit.edu
