Heather Denroche
Heather Denroche
Post doctoral fellow, Child & Family Research Institute
Verified email at
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Circulating miR-375 as a biomarker of β-cell death and diabetes in mice
S Erener, M Mojibian, JK Fox, HC Denroche, TJ Kieffer
Endocrinology 154 (2), 603-608, 2013
The role of leptin in glucose homeostasis
HC Denroche, FK Huynh, TJ Kieffer
Journal of diabetes investigation 3 (2), 115-129, 2012
IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance
JM Han, D Wu, HC Denroche, Y Yao, CB Verchere, MK Levings
The Journal of Immunology 194 (10), 4777-4783, 2015
Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
HC Denroche, J Levi, RD Wideman, RM Sequeira, FK Huynh, SD Covey, ...
Diabetes 60 (5), 1414-1423, 2011
Disruption of hepatic leptin signaling protects mice from age-and diet-related glucose intolerance
FK Huynh, J Levi, HC Denroche, SL Gray, PJ Voshol, UH Neumann, ...
Diabetes 59 (12), 3032-3040, 2010
IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
CY Westwell-Roper, CA Chehroudi, HC Denroche, JA Courtade, ...
Diabetologia 58, 575-585, 2015
IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants
HC Denroche, CB Verchere
Journal of molecular endocrinology 60 (2), R57-R75, 2018
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates
C Westwell-Roper, HC Denroche, JA Ehses, CB Verchere
Journal of Biological Chemistry 291 (17), 8908-8917, 2016
Amyloid formation in human islets is enhanced by heparin and inhibited by heparinase
KJ Potter, I Werner, HC Denroche, J Montane, A Plesner, Y Chen, D Lei, ...
American journal of transplantation 15 (6), 1519-1530, 2015
Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice
J Levi, FK Huynh, HC Denroche, UH Neumann, MM Glavas, SD Covey, ...
Diabetologia 55, 752-762, 2012
Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol
HC Denroche, MM Kwon, WL Quong, UH Neumann, JE Kulpa, ...
Diabetologia 58, 1100-1108, 2015
Insulin knockout mice have extended survival but volatile blood glucose levels on leptin therapy
UH Neumann, HC Denroche, M Mojibian, SD Covey, TJ Kieffer
Endocrinology 157 (3), 1007-1012, 2016
Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis
E Tudurí, HC Denroche, JA Kara, A Asadi, JK Fox, TJ Kieffer
American Journal of Physiology-Endocrinology and Metabolism 306 (7), E748-E755, 2014
Disrupted leptin signaling in the lateral hypothalamus and ventral premammillary nucleus alters insulin and glucagon secretion and protects against diet-induced obesity
HC Denroche, MM Glavas, E Tudurí, S Karunakaran, WL Quong, ...
Endocrinology 157 (7), 2671-2685, 2016
Leptin administration enhances islet transplant performance in diabetic mice
HC Denroche, WL Quong, JE Bruin, E Tudurí, A Asadi, MM Glavas, ...
Diabetes 62 (8), 2738-2746, 2013
AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects
A Ramzy, E Tudurí, MM Glavas, RK Baker, M Mojibian, JK Fox, ...
Scientific Reports 10 (1), 10518, 2020
The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy
HC Denroche, MM Kwon, MM Glavas, E Tudurí, M Philippe, WL Quong, ...
Molecular metabolism 5 (8), 716-724, 2016
T cells accumulate in non-diabetic islets during ageing
HC Denroche, S Miard, S Sallé-Lefort, F Picard, CB Verchere
Immunity & Ageing 18, 1-13, 2021
Impaired Ca2+ Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination
E Tudurí, JE Bruin, HC Denroche, JK Fox, JD Johnson, TJ Kieffer
PLoS One 8 (8), e71075, 2013
When beta cells talk back
HC Denroche, D Nackiewicz, CB Verchere
Diabetologia 61 (1), 39-42, 2018
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