Max Horlbeck
Max Horlbeck
Boston Children's Hospital
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Genome-scale CRISPR-mediated control of gene repression and activation
LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ...
Cell 159 (3), 647-661, 2014
A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response
B Adamson, TM Norman, M Jost, MY Cho, JK Nu˝ez, Y Chen, JE Villalta, ...
Cell 167 (7), 1867-1882. e21, 2016
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
SJ Liu, MA Horlbeck, SW Cho, HS Birk, M Malatesta, D He, FJ Attenello, ...
Science 355 (6320), 2017
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ...
Cell 152 (4), 909-922, 2013
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
MA Horlbeck, LA Gilbert, JE Villalta, B Adamson, RA Pak, Y Chen, ...
Elife 5, e19760, 2016
CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs
MA Mandegar, N Huebsch, EB Frolov, E Shin, A Truong, MP Olvera, ...
Cell stem cell 18 (4), 541-553, 2016
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
MA Horlbeck, LB Witkowsky, B Guglielmi, JM Replogle, LA Gilbert, ...
elife 5, e12677, 2016
Single-cell analysis of long non-coding RNAs in the developing human neocortex
SJ Liu, TJ Nowakowski, AA Pollen, JH Lui, MA Horlbeck, FJ Attenello, ...
Genome biology 17 (1), 67, 2016
Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element
SW Cho, J Xu, R Sun, MR Mumbach, AC Carter, YG Chen, KE Yost, J Kim, ...
Cell 173 (6), 1398-1412. e22, 2018
ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p
A Čopič, CF Latham, MA Horlbeck, JG D’Arcangelo, EA Miller
Science 335 (6074), 1359-1362, 2012
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
RM Deans, DW Morgens, A Íkesli, S Pillay, MA Horlbeck, M Kampmann, ...
Nature chemical biology 12 (5), 361-366, 2016
Mapping the genetic landscape of human cells
MA Horlbeck, A Xu, M Wang, NK Bennett, CY Park, D Bogdanoff, ...
Cell 174 (4), 953-967. e22, 2018
Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent
M Jost, Y Chen, LA Gilbert, MA Horlbeck, L Krenning, G Menchon, A Rai, ...
Molecular cell 68 (1), 210-223. e6, 2017
Next-generation libraries for robust RNA interference-based genome-wide screens
M Kampmann, MA Horlbeck, Y Chen, JC Tsai, MC Bassik, LA Gilbert, ...
Proceedings of the National Academy of Sciences 112 (26), E3384-E3391, 2015
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
CJ Braun, PM Bruno, MA Horlbeck, LA Gilbert, JS Weissman, MT Hemann
Proceedings of the National Academy of Sciences 113 (27), E3892-E3900, 2016
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
TM Norman, MA Horlbeck, JM Replogle, YG Alex, A Xu, M Jost, LA Gilbert, ...
Science 365 (6455), 786-793, 2019
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins
AJ Martinko, C Truillet, O Julien, JE Diaz, MA Horlbeck, G Whiteley, ...
Elife 7, e31098, 2018
Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform
KJ Wangensteen, YJ Wang, Z Dou, AW Wang, E Mosleh‐Shirazi, ...
Hepatology 68 (2), 663-676, 2018
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
M Jost, DA Santos, RA Saunders, MA Horlbeck, JS Hawkins, SM Scaria, ...
Nature Biotechnology 38 (3), 355-364, 2020
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure
BA Mendelsohn, NK Bennett, MA Darch, K Yu, MK Nguyen, D Pucciarelli, ...
PLoS biology 16 (8), e2004624, 2018
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