Frederic Couture
Frederic Couture
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On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications
F Couture, F D'Anjou, R Day
Biomolecular concepts 2 (5), 421-438, 2011
Role of proprotein convertases in prostate cancer progression
F Couture, F D'Anjou, R Desjardins, F Boudreau, R Day
Neoplasia 14 (11), 1032-IN6, 2012
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells
C Levesque, M Fugère, A Kwiatkowska, F Couture, R Desjardins, ...
Journal of medicinal chemistry 55 (23), 10501-10511, 2012
Therapeutic uses of furin and its inhibitors: a patent review
F Couture, A Kwiatkowska, YL Dory, R Day
Expert opinion on therapeutic patents 25 (4), 379-396, 2015
Design, synthesis, and structure–activity relationship studies of a potent PACE4 inhibitor
A Kwiatkowska, F Couture, C Levesque, K Ly, R Desjardins, ...
Journal of medicinal chemistry 57 (1), 98-109, 2014
Implications of proprotein convertases in ovarian cancer cell proliferation and tumor progression: insights for PACE4 as a therapeutic target
R Longuespée, F Couture, C Levesque, A Kwiatkowska, R Desjardins, ...
Translational Oncology 7 (3), 410-419, 2014
PACE4 undergoes an oncogenic alternative splicing switch in cancer
F Couture, R Sabbagh, A Kwiatkowska, R Desjardins, SP Guay, ...
Cancer research 77 (24), 6863-6879, 2017
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation.
C Levesque, F Couture, A Kwiatkowska, R Desjardins, B Guérin, ...
Oncotarget, 2015
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin
H Gagnon, S Beauchemin, A Kwiatkowska, F Couture, F D’Anjou, ...
Journal of Medicinal Chemistry 57 (1), 29-41, 2014
Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors
A Kwiatkowska, F Couture, C Levesque, K Ly, S Beauchemin, ...
ChemMedChem 11 (3), 289-301, 2016
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression
F Panet, F Couture, A Kwiatkowska, R Desjardins, B Guérin, R Day
European Journal of Cell Biology 96 (5), 469-475, 2017
PACE4-based molecular targeting of prostate cancer using an engineered 64Cu-radiolabeled peptide inhibitor
F Couture, C Levesque, V Dumulon-Perreault, S Ait-Mohand, F D’Anjou, ...
Neoplasia 16 (8), 634-643, 2014
Positional scanning identifies the molecular determinants of a high affinity multi-leucine inhibitor for furin and PACE4
I Małuch, C Levesque, A Kwiatkowska, F Couture, K Ly, R Desjardins, ...
Journal of Medicinal Chemistry 60 (7), 2732-2744, 2017
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells
F D’Anjou, F Couture, R Desjardins, R Day
Therapeutic Applications of Ribozymes and Riboswitches, 67-82, 2014
Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations
T Łepek, A Kwiatkowska, F Couture, K Ly, R Desjardins, Y Dory, A Prahl, ...
European Journal of Cell Biology 96 (5), 476-485, 2017
Multi-Leu PACE4 inhibitor retention within cells is PACE4 dependent and a prerequisite for antiproliferative activity
F Couture, K Ly, C Levesque, A Kwiatkowska, S Ait-Mohand, ...
BioMed Research International 2015, 2015
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug
A Kwiatkowska, F Couture, S Ait-Mohand, R Desjardins, YL Dory, ...
Scientific reports 9 (1), 1-12, 2019
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer
L Fradet, R Temmar, F Couture, M Belzile, PH Fortier, R Day
Journal of Otolaryngology-Head & Neck Surgery 47 (1), 63, 2018
WITHDRAWN: PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity
K Okada, HJ Moon, J Finney, F Couture, R Day, M Mure
Journal of Biological Chemistry, jbc. C117. 810978, 2017
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss
AH Mohammad, S Assadian, F Couture, KJ Lefebvre, W El-Assaad, ...
Oncotarget 10 (48), 4923, 2019
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