Stephen C Kales
Stephen C Kales
National Center for Advancing Translational Sciences
Verified email at
Cited by
Cited by
Assay guidance manual [Internet]
GS Sittampalam, A Grossman, K Brimacombe, M Arkin, D Auld, CP Austin, ...
Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004
Cbl and human myeloid neoplasms: the Cbl oncogene comes of age
SC Kales, PE Ryan, MM Nau, S Lipkowitz
Cancer research 70 (12), 4789-4794, 2010
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases
YHC Tan, S Krishnaswamy, S Nandi, R Kanteti, S Vora, K Onel, R Hasina, ...
PloS one 5 (1), e8972, 2010
KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance
K Hinohara, HJ Wu, S Vigneau, TO McDonald, KJ Igarashi, KN Yamamoto, ...
Cancer cell 34 (6), 939-953. e9, 2018
Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds
JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, ...
Cell chemical biology 23 (7), 769-781, 2016
KDM5 histone demethylases repress immune response via suppression of STING
L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, ...
PLoS biology 16 (8), e2006134, 2018
Major histocompatibility class II genes in rainbow trout (Oncorhynchus mykiss) exhibit temperature dependent downregulation
S Nath, S Kales, K Fujiki, B Dixon
Immunogenetics 58 (5), 443-453, 2006
Molecular cloning and characterization of calreticulin from rainbow trout (Oncorhynchus mykiss)
S Kales, K Fujiki, B Dixon
Immunogenetics 55 (10), 717-723, 2004
A Cell Line (HEW) from Embryos of Haddock (Melanogrammus aeglefinius) and Its Capacity to Tolerate Environmental Extremes
SP Bryson, EM Joyce, DJ Martell, LEJ Lee, SE Holt, SC Kales, K Fujiki, ...
Marine Biotechnology 8 (6), 641-653, 2006
An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19
JH Shrimp, SC Kales, PE Sanderson, A Simeonov, M Shen, MD Hall
bioRxiv, 2020
Calreticulin in rainbow trout: a limited response to endoplasmic reticulum (ER) stress
SC Kales, NC Bols, B Dixon
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular …, 2007
An OpenData portal to share COVID-19 drug repurposing data in real time
KR Brimacombe, T Zhao, RT Eastman, X Hu, K Wang, M Backus, ...
bioRxiv, 2020
Response of the rainbow trout monocyte/macrophage cell line, RTS11 to the water molds Achlya and Saprolegnia
SC Kales, SJ DeWitte-Orr, NC Bols, B Dixon
Molecular immunology 44 (9), 2303-2314, 2007
Beta-2-microglobulin gene expression is maintained in rainbow trout and Atlantic salmon kept at low temperatures
S Kales, J Parks-Dely, P Schulte, B Dixon
Fish & shellfish immunology 21 (2), 176-186, 2006
Balancing protein stability and activity in cancer: a new approach for identifying driver mutations affecting CBL ubiquitin ligase activation
M Li, SC Kales, K Ma, BA Shoemaker, J Crespo-Barreto, AL Cangelosi, ...
Cancer research 76 (3), 561-571, 2016
Cbl exposes its RING finger
SC Kales, PE Ryan, S Lipkowitz
Nature structural & molecular biology 19 (2), 131-133, 2012
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
NP Coussens, SC Kales, MJ Henderson, OW Lee, KY Horiuchi, Y Wang, ...
Journal of Biological Chemistry 293 (35), 13750-13765, 2018
Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A
SC Kales, MM Nau, AS Merchant, S Lipkowitz
PloS one 9 (1), e87116, 2014
A comparison of rainbow trout cell lines for their expression of the major histocompatibility complex genes and the induction of beta-2-microglobulin by dsRNA
A Kawano, SC Kales, K Fujiki, SJ DeWitte-Orr, B Dixon, LEJ Lee, NC Bols
Fish & shellfish immunology 29 (2), 312-318, 2010
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
NP Coussens, GS Sittampalam, R Guha, K Brimacombe, A Grossman, ...
Clinical and translational science 11 (5), 461-470, 2018
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