| Elabela/toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the … P Yang, C Read, RE Kuc, G Buonincontri, M Southwood, R Torella, ... Circulation 135 (12), 1160-1173, 2017 | 230 | 2017 |
| Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist AL Brame, JJ Maguire, P Yang, A Dyson, R Torella, J Cheriyan, M Singer, ... Hypertension 65 (4), 834-840, 2015 | 168 | 2015 |
| Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy R Ronca, A Giacomini, E Di Salle, D Coltrini, K Pagano, L Ragona, ... Cancer cell 28 (2), 225-239, 2015 | 115 | 2015 |
| Mechanism for priming DNA synthesis by yeast DNA polymerase α RL Perera, R Torella, S Klinge, ML Kilkenny, JD Maman, L Pellegrini Elife 2, e00482, 2013 | 115 | 2013 |
| DeltaDelta neural networks for lead optimization of small molecule potency J Jiménez-Luna, L Pérez-Benito, G Martinez-Rosell, S Sciabola, R Torella, ... Chemical science 10 (47), 10911-10918, 2019 | 61 | 2019 |
| Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster Z Yuan, H Praxenthaler, N Tabaja, R Torella, A Preiss, D Maier, RA Kovall PLoS biology 14 (7), e1002509, 2016 | 53 | 2016 |
| Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias JD Hothersall, R Torella, S Humphreys, M Hooley, A Brown, G McMurray, ... Neuropharmacology 118, 46-58, 2017 | 46 | 2017 |
| Prediction of cytochrome P450 xenobiotic metabolism: tethered docking and reactivity derived from ligand molecular orbital analysis JD Tyzack, MJ Williamson, R Torella, RC Glen Journal of chemical information and modeling 53 (6), 1294-1305, 2013 | 46 | 2013 |
| Network-based drug discovery: coupling network pharmacology with phenotypic screening for neuronal excitability B Sidders, A Karlsson, L Kitching, R Torella, P Karila, A Phelan Journal of molecular biology 430 (18), 3005-3015, 2018 | 44 | 2018 |
| Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule K Pagano, R Torella, C Foglieni, A Bugatti, S Tomaselli, L Zetta, M Presta, ... PLoS One 7 (5), e36990, 2012 | 43 | 2012 |
| Ensemble-and rigidity theory-based perturbation approach to analyze dynamic allostery C Pfleger, A Minges, M Boehm, CL McClendon, R Torella, H Gohlke Journal of Chemical Theory and Computation 13 (12), 6343-6357, 2017 | 33 | 2017 |
| Valproic acid interactions with the NavMs voltage-gated sodium channel G Zanatta, A Sula, AJ Miles, LCT Ng, R Torella, DC Pryde, PG DeCaen, ... Proceedings of the National Academy of Sciences 116 (52), 26549-26554, 2019 | 29 | 2019 |
| Cosolvent-enhanced sampling and unbiased identification of cryptic pockets suitable for structure-based drug design D Schmidt, M Boehm, CL McClendon, R Torella, H Gohlke Journal of chemical theory and computation 15 (5), 3331-3343, 2019 | 29 | 2019 |
| Highly potent and selective NaV1. 7 inhibitors for use as intravenous agents and chemical probes RI Storer, A Pike, NA Swain, AJ Alexandrou, BM Bechle, DC Blakemore, ... Bioorganic & Medicinal Chemistry Letters 27 (21), 4805-4811, 2017 | 29 | 2017 |
| An intracellular allosteric modulator binding pocket in SK2 ion channels is shared by multiple chemotypes LTY Cho, AJ Alexandrou, R Torella, J Knafels, J Hobbs, T Taylor, A Loucif, ... Structure 26 (4), 533-544. e3, 2018 | 28 | 2018 |
| Lateral Fenestrations in K+-Channels Explored Using Molecular Dynamics Simulations C Jorgensen, L Darré, V Oakes, R Torella, D Pryde, C Domene Molecular pharmaceutics 13 (7), 2263-2273, 2016 | 27 | 2016 |
| Discovery of compounds that positively modulate the high affinity choline transporter P Choudhary, EJ Armstrong, CC Jorgensen, M Piotrowski, M Barthmes, ... Frontiers in Molecular Neuroscience 10, 40, 2017 | 19 | 2017 |
| A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL R Torella, J Li, E Kinrade, G Cerda-Moya, AN Contreras, R Foy, R Stojnic, ... Nucleic acids research 42 (16), 10550-10563, 2014 | 17 | 2014 |
| Investigating dynamic and energetic determinants of protein nucleic acid recognition: analysis of the zinc finger zif268-DNA complexes R Torella, E Moroni, M Caselle, G Morra, G Colombo BMC structural Biology 10, 1-18, 2010 | 16 | 2010 |
| Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor B Kelly, SA Hollingsworth, DC Blakemore, RM Owen, RI Storer, NA Swain, ... Journal of Chemical Information and Modeling 61 (7), 3696-3707, 2021 | 14 | 2021 |
