Michael Downey
Cited by
Cited by
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
MC Keogh, JA Kim, M Downey, J Fillingham, D Chowdhury, JC Harrison, ...
Nature 439 (7075), 497-501, 2006
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator
M Downey, R Houlsworth, L Maringele, A Rollie, M Brehme, S Galicia, ...
Cell 124 (6), 1155-1168, 2006
A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae
SG Addinall, M Downey, M Yu, MK Zubko, J Dewar, A Leake, J Hallinan, ...
Genetics 180 (4), 2251-2266, 2008
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine
DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ...
Molecular cell 32 (2), 259-275, 2008
γH2AX as a checkpoint maintenance signal
M Downey, D Durocher
Cell Cycle 5 (13), 1376-1381, 2006
Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1
M Downey, JR Johnson, NE Davey, BW Newton, TL Johnson, S Galaang, ...
Molecular & Cellular Proteomics 14 (1), 162-176, 2015
Chromatin and DNA repair: the benefits of relaxation
M Downey, D Durocher
Nature Cell Biology 8 (1), 9-10, 2006
Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1
M Downey, B Knight, AA Vashisht, CA Seller, JA Wohlschlegel, D Shore, ...
Current Biology 23 (17), 1638-1648, 2013
Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme
L Holland, M Downey, X Song, L Gauthier, P Bell‐Rogers, K Yankulov
European journal of biochemistry 269 (21), 5192-5202, 2002
A screen for candidate targets of lysine polyphosphorylation uncovers a conserved network implicated in ribosome biogenesis
A Bentley-DeSousa, C Holinier, H Moteshareie, YC Tseng, S Kajjo, ...
Cell reports 22 (13), 3427-3439, 2018
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin
S McCracken, D Longman, E Marcon, P Moens, M Downey, JA Nickerson, ...
Journal of Biological Chemistry 280 (51), 42227-42236, 2005
Polymerase stalling during replication, transcription and translation
ER Edenberg, M Downey, D Toczyski
Current Biology 24 (10), R445-R452, 2014
Building a KATalogue of acetyllysine targeting and function
M Downey, K Baetz
Briefings in functional genomics 15 (2), 109-118, 2016
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
R Sebaa, J Johnson, C Pileggi, M Norgren, J Xuan, Y Sai, Q Tong, ...
Molecular metabolism 25, 35-49, 2019
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation
EM Da Costa, G Armaos, G McInnes, A Beaudry, G Moquin-Beaudry, ...
Journal of Experimental & Clinical Cancer Research 38 (1), 1-14, 2019
Nonhistone targets of KAT2A and KAT2B implicated in cancer biology
E Bondy-Chorney, A Denoncourt, Y Sai, M Downey
Biochemistry and Cell Biology 97 (1), 30-45, 2019
A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs
A Rössl, A Denoncourt, MS Lin, M Downey
Journal of Biological Chemistry 294 (16), 6227-6239, 2019
From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation
A Bentley-DeSousa, M Downey
Current genetics 65 (1), 57-64, 2019
Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases
A Rössl, A Bentley-DeSousa, YC Tseng, C Nwosu, M Downey
Genetics 204 (2), 569-579, 2016
Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast
L McCarthy, A Bentley‐DeSousa, A Denoncourt, YC Tseng, M Gabriel, ...
FEBS letters 594 (1), 21-30, 2020
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