The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system T Pelaseyed, JH Bergström, JK Gustafsson, A Ermund, GMH Birchenough, ... Immunological reviews 260 (1), 8-20, 2014 | 1245 | 2014 |
New developments in goblet cell mucus secretion and function GMH Birchenough, MEV Johansson, JK Gustafsson, JH Bergström, ... Mucosal immunology 8 (4), 712-719, 2015 | 719 | 2015 |
Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration BO Schroeder, GMH Birchenough, M Ståhlman, L Arike, MEV Johansson, ... Cell host & microbe 23 (1), 27-40. e7, 2018 | 602 | 2018 |
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion GMH Birchenough, EEL Nyström, MEV Johansson, GC Hansson Science 352 (6293), 1535-1542, 2016 | 537 | 2016 |
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis S van der Post, KS Jabbar, G Birchenough, L Arike, N Akhtar, H Sjovall, ... Gut 68 (12), 2142-2151, 2019 | 333 | 2019 |
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function EEL Nyström, B Martinez-Abad, L Arike, GMH Birchenough, EB Nonnecke, ... Science 372 (6539), eabb1590, 2021 | 173 | 2021 |
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16 JH Bergström, GMH Birchenough, G Katona, BO Schroeder, A Schütte, ... Proceedings of the National Academy of Sciences 113 (48), 13833-13838, 2016 | 144 | 2016 |
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function JK Volk, EEL Nyström, S van der Post, BM Abad, BO Schroeder, ... Journal of Experimental Medicine 216 (11), 2602-2618, 2019 | 93 | 2019 |
Hypervirulent Clostridium difficile PCR-ribotypes exhibit resistance to widely used disinfectants LF Dawson, E Valiente, EH Donahue, G Birchenough, BW Wren PloS one 6 (10), e25754, 2011 | 83 | 2011 |
Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier G Birchenough, BO Schroeder, F Bäckhed, GC Hansson Gut Microbes 10 (2), 246-250, 2019 | 80 | 2019 |
Calcium-activated chloride channel regulator 1 (CLCA1) controls mucus expansion in colon by proteolytic activity EEL Nyström, GMH Birchenough, S van der Post, L Arike, AD Gruber, ... EBioMedicine 33, 134-143, 2018 | 80 | 2018 |
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli GMH Birchenough, MEV Johansson, RA Stabler, F Dalgakiran, ... Infection and immunity 81 (9), 3264-3275, 2013 | 44 | 2013 |
Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice BO Schroeder, GMH Birchenough, M Pradhan, EEL Nyström, ... Journal of Biological Chemistry 295 (46), 15712-15726, 2020 | 37 | 2020 |
The goblet cell protein Clca1 (alias mClca3 or Gob-5) is not required for intestinal mucus synthesis, structure and barrier function in naive or DSS-challenged mice NA Erickson, EEL Nyström, L Mundhenk, L Arike, R Glauben, ... PLoS One 10 (7), e0131991, 2015 | 32 | 2015 |
Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1 A Zelmer, MJ Martin, O Gundogdu, G Birchenough, R Lever, BW Wren, ... Microbiology 156 (7), 2205-2215, 2010 | 32 | 2010 |
NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation S van der Post, GMH Birchenough, JM Held Cell reports 35 (1), 2021 | 31 | 2021 |
Functional mucous layer and healing of proximal colonic anastomoses in an experimental model J Bosmans, A Jongen, GMH Birchenough, EEL Nyström, MJJ Gijbels, ... Journal of British Surgery 104 (5), 619-630, 2017 | 27 | 2017 |
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer JDA Sharpen, B Dolan, EEL Nyström, GMH Birchenough, L Arike, ... Nature Communications 13 (1), 45, 2022 | 24 | 2022 |
Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection GMH Birchenough, F Dalgakiran, LA Witcomb, MEV Johansson, ... Scientific reports 7 (1), 83, 2017 | 24 | 2017 |
Non-invasive model of neuropathogenic Escherichia coli infection in the neonatal rat F Dalgakiran, LA Witcomb, AJ McCarthy, GMH Birchenough, PW Taylor JoVE (Journal of Visualized Experiments), e52018, 2014 | 23 | 2014 |