Murali Prakriya
Murali Prakriya
Department of Pharmacology, Northwestern University
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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
S Feske, Y Gwack, M Prakriya, S Srikanth, SH Puppel, B Tanasa, ...
Nature 441 (7090), 179-185, 2006
Orai1 is an essential pore subunit of the CRAC channel
M Prakriya, S Feske, Y Gwack, S Srikanth, A Rao, PG Hogan
Nature 443 (7108), 230-233, 2006
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
LA Sena, S Li, A Jairaman, M Prakriya, T Ezponda, DA Hildeman, ...
Immunity 38 (2), 225-236, 2013
Store-operated calcium channels
M Prakriya, RS Lewis
Physiological reviews, 2015
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
M Oh-Hora, M Yamashita, PG Hogan, S Sharma, E Lamperti, W Chung, ...
Nature immunology 9 (4), 432-443, 2008
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
RM Luik, B Wang, M Prakriya, MM Wu, RS Lewis
Nature 454 (7203), 538-542, 2008
Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP3 receptors
M Prakriya, RS Lewis
The Journal of physiology 536 (Pt 1), 3, 2001
Ion channels and transporters in lymphocyte function and immunity
S Feske, EY Skolnik, M Prakriya
Nature Reviews Immunology 12 (7), 532-547, 2012
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels
PT Mungai, GB Waypa, A Jairaman, M Prakriya, D Dokic, MK Ball, ...
Molecular and cellular biology 31 (17), 3531-3545, 2011
Separation and Characterization of Currents through Store-operated CRAC Channels and Mg2+-inhibited Cation (MIC) Channels
M Prakriya, RS Lewis
The Journal of general physiology 119 (5), 487-508, 2002
Hair loss and defective T-and B-cell function in mice lacking ORAI1
Y Gwack, S Srikanth, M Oh-Hora, PG Hogan, ED Lamperti, M Yamashita, ...
Molecular and cellular biology 28 (17), 5209-5222, 2008
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
S Feske, M Prakriya, A Rao, RS Lewis
The Journal of experimental medicine 202 (5), 651-662, 2005
Gated regulation of CRAC channel ion selectivity by STIM1
BA McNally, A Somasundaram, M Yamashita, M Prakriya
Nature 482 (7384), 241-245, 2012
STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy
L Navarro‐Borelly, A Somasundaram, M Yamashita, D Ren, RJ Miller, ...
The Journal of physiology 586 (22), 5383-5401, 2008
CRAC channels: activation, permeation, and the search for a molecular identity
M Prakriya, RS Lewis
Cell calcium 33 (5-6), 311-321, 2003
Structural determinants of ion permeation in CRAC channels
BA McNally, M Yamashita, A Engh, M Prakriya
Proceedings of the National Academy of Sciences 106 (52), 22516-22521, 2009
Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
GA Gusarova, HE Trejo, LA Dada, A Briva, LC Welch, RB Hamanaka, ...
Molecular and cellular biology 31 (17), 3546-3556, 2011
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
KM Woolfrey, DP Srivastava, H Photowala, M Yamashita, MV Barbolina, ...
Nature neuroscience 12 (10), 1275-1284, 2009
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
M Vaeth, J Yang, M Yamashita, I Zee, M Eckstein, C Knosp, U Kaufmann, ...
Nature communications 8 (1), 1-17, 2017
Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode
M Prakriya, RS Lewis
The Journal of general physiology 128 (3), 373-386, 2006
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