| Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ... Nature protocols 2 (11), 2692, 2007 | 1453 | 2007 |
| Human metabolic phenotype diversity and its association with diet and blood pressure E Holmes, RL Loo, J Stamler, M Bictash, IKS Yap, Q Chan, T Ebbels, ... Nature 453 (7193), 396, 2008 | 903 | 2008 |
| Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project JC Lindon, JK Nicholson, E Holmes, H Antti, ME Bollard, H Keun, ... Toxicology and applied pharmacology 187 (3), 137-146, 2003 | 461 | 2003 |
| Proposed minimum reporting standards for data analysis in metabolomics R Goodacre, D Broadhurst, AK Smilde, BS Kristal, JD Baker, R Beger, ... Metabolomics 3 (3), 231-241, 2007 | 337 | 2007 |
| High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues O Beckonert, M Coen, HC Keun, Y Wang, TMD Ebbels, E Holmes, ... Nature protocols 5 (6), 1019, 2010 | 304 | 2010 |
| The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements JC Lindon, HC Keun, TMD Ebbels, JMT Pearce, E Holmes, JK Nicholson Future Medicine Ltd 6 (7), 691-699, 2005 | 295 | 2005 |
| Analytical reproducibility in 1H NMR-based metabonomic urinalysis HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, G Schlotterbeck, ... Chemical research in toxicology 15 (11), 1380-1386, 2002 | 274 | 2002 |
| Recursive Segment-Wise Peak Alignment of Biological 1H NMR Spectra for Improved Metabolic Biomarker Recovery KA Veselkov, JC Lindon, TMD Ebbels, D Crockford, VV Volynkin, ... Analytical chemistry 81 (1), 56-66, 2008 | 269 | 2008 |
| Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery KA Veselkov, LK Vingara, P Masson, SL Robinette, E Want, JV Li, ... Analytical chemistry 83 (15), 5864-5872, 2011 | 202 | 2011 |
| Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA A Kamburov, R Cavill, TMD Ebbels, R Herwig, HC Keun Bioinformatics 27 (20), 2917-2918, 2011 | 199 | 2011 |
| Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues Y Wang, ME Bollard, H Keun, H Antti, O Beckonert, TM Ebbels, JC Lindon, ... Analytical biochemistry 323 (1), 26-32, 2003 | 190 | 2003 |
| Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach TMD Ebbels, HC Keun, OP Beckonert, ME Bollard, JC Lindon, E Holmes, ... Journal of proteome research 6 (11), 4407-4422, 2007 | 188 | 2007 |
| Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, E Holmes, ... Analytica chimica acta 490 (1-2), 265-276, 2003 | 179 | 2003 |
| NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches O Beckonert, ME Bollard, TMD Ebbels, HC Keun, H Antti, E Holmes, ... Analytica Chimica Acta 490 (1-2), 3-15, 2003 | 156 | 2003 |
| Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles HC Keun, TMD Ebbels, ME Bollard, O Beckonert, H Antti, E Holmes, ... Chemical research in toxicology 17 (5), 579-587, 2004 | 145 | 2004 |
| Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS P Masson, AC Alves, TMD Ebbels, JK Nicholson, EJ Want Analytical Chemistry 82 (18), 7779-7786, 2010 | 144 | 2010 |
| Comparative metabonomics of differential hydrazine toxicity in the rat and mouse ME Bollard, HC Keun, O Beckonert, TMD Ebbels, H Antti, AW Nicholls, ... Toxicology and applied pharmacology 204 (2), 135-151, 2005 | 139 | 2005 |
| The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping JM Fonville, SE Richards, RH Barton, CL Boulange, TMD Ebbels, ... Journal of Chemometrics 24 (11‐12), 636-649, 2010 | 127 | 2010 |
| Opening up the" Black Box": Metabolic phenotyping and metabolome-wide association studies in epidemiology M Bictash, TM Ebbels, Q Chan, RL Loo, IKS Yap, IJ Brown, M De Iorio, ... Journal of clinical epidemiology 63 (9), 970-979, 2010 | 127 | 2010 |
| Design and analysis of metabolomics studies in epidemiologic research: a primer on-omic technologies I Tzoulaki, TMD Ebbels, A Valdes, P Elliott, JPA Ioannidis American journal of epidemiology 180 (2), 129-139, 2014 | 107 | 2014 |
Elaine HolmesImperial CollegeVerified email at imperial.ac.uk