| Mammalian multidrug-resistance proteins (MRPs) AJ Slot, SV Molinski, SPC Cole Essays in biochemistry 50, 179-207, 2011 | 267 | 2011 |
| Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics JJ Hernandez, M Pryszlak, L Smith, C Yanchus, N Kurji, VM Shahani, ... Frontiers in oncology 7, 273, 2017 | 247 | 2017 |
| VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface PDW Eckford, M Ramjeesingh, S Molinski, S Pasyk, JF Dekkers, C Li, ... Chemistry & biology 21 (5), 666-678, 2014 | 113 | 2014 |
| Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue SV Molinski, S Ahmadi, W Ip, H Ouyang, A Villella, JP Miller, PS Lee, ... EMBO molecular medicine 9 (9), 1224-1243, 2017 | 106 | 2017 |
| Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia S Ahmadi, Z Bozoky, M Di Paola, S Xia, C Li, AP Wong, L Wellhauser, ... NPJ genomic medicine 2 (1), 12, 2017 | 69 | 2017 |
| Functional rescue of F508del-CFTR using small molecule correctors S Molinski, PDW Eckford, S Pasyk, S Ahmadi, S Chin, CE Bear Frontiers in pharmacology 3, 160, 2012 | 54 | 2012 |
| Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site SV Molinski, VM Shahani, AS Subramanian, SS MacKinnon, G Woollard, ... Proteins: Structure, Function, and Bioinformatics 86 (8), 833-843, 2018 | 51 | 2018 |
| Correctors of the major cystic fibrosis mutant interact through membrane-spanning domains O Laselva, S Molinski, V Casavola, CE Bear Molecular Pharmacology 93 (6), 612-618, 2018 | 48 | 2018 |
| Facilitating structure-function studies of CFTR modulator sites with efficiencies in mutagenesis and functional screening SV Molinski, S Ahmadi, M Hung, CE Bear Journal of biomolecular screening 20 (10), 1204-1217, 2015 | 45 | 2015 |
| Sphingosine-1-phosphate is a novel regulator of cystic fibrosis transmembrane conductance regulator (CFTR) activity FA Malik, A Meissner, I Semenkov, S Molinski, S Pasyk, S Ahmadi, HH Bui, ... PLoS One 10 (6), e0130313, 2015 | 44 | 2015 |
| Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention SV Molinski, T Gonska, LJ Huan, B Baskin, IA Janahi, PN Ray, CE Bear Genetics in Medicine 16 (8), 625-632, 2014 | 43 | 2014 |
| The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain O Laselva, S Molinski, V Casavola, CE Bear Biochemical Pharmacology 119, 85-92, 2016 | 38 | 2016 |
| The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation S Pasyk, S Molinski, S Ahmadi, M Ramjeesingh, LJ Huan, S Chin, K Du, ... Proteomics 15 (2-3), 447-461, 2015 | 30 | 2015 |
| Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells R Aslam, M Kim, ER Speck, AC Seetanah, S Molinski, J Freedman, ... Transfusion 47 (11), 2161-2168, 2007 | 27 | 2007 |
| Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5 C D’Antonio, S Molinski, S Ahmadi, LJ Huan, L Wellhauser, CE Bear Biochemical Journal 452 (3), 391-400, 2013 | 25 | 2013 |
| Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474 SV Molinski, VM Shahani, SS MacKinnon, LD Morayniss, M Laforet, ... Biochemical and biophysical research communications 483 (1), 502-508, 2017 | 19 | 2017 |
| The antiretroviral agent nelfinavir mesylate: a potential therapy for systemic sclerosis CG Sanchez, SV Molinski, R Gongora, M Sosulski, T Fuselier, ... Arthritis & Rheumatology 70 (1), 115-126, 2018 | 16 | 2018 |
| Identification and validation of hits from high throughput screens for CFTR modulators S Pasyk, S Molinski, W Yu, P DW Eckford, C E Bear Current pharmaceutical design 18 (5), 628-641, 2012 | 13 | 2012 |
| Biophysical approaches facilitate computational drug discovery for ATP-binding cassette proteins SV Molinski, Z Bozóky, SH Iram, S Ahmadi International Journal of Medicinal Chemistry 2017, 2017 | 10 | 2017 |
| Attenuation of phosphorylation-dependent activation of cystic fibrosis transmembrane conductance regulator (CFTR) by disease-causing mutations at the transmission interface S Chin, D Yang, AJ Miles, PDW Eckford, S Molinski, BA Wallace, CE Bear Journal of Biological Chemistry 292 (5), 1988-1999, 2017 | 8 | 2017 |
