Gaetan Mayer, PhD Co-founder/CSO Monogenic Pharmaceuticals
Gaetan Mayer, PhD Co-founder/CSO Monogenic Pharmaceuticals
Professor, Faculty of Pharmacy, Université de Montréal
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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
S Poirier, G Mayer, S Benjannet, E Bergeron, J Marcinkiewicz, ...
Journal of Biological Chemistry 283 (4), 2363-2372, 2008
The activation and physiological functions of the proprotein convertases
NG Seidah, G Mayer, A Zaid, E Rousselet, N Nassoury, S Poirier, ...
The international journal of biochemistry & cell biology 40 (6-7), 1111-1125, 2008
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation evidence for an intracellular route
S Poirier, G Mayer, V Poupon, PS McPherson, R Desjardins, K Ly, ...
Journal of biological Chemistry 284 (42), 28856-28864, 2009
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression
P Labonté, S Begley, C Guévin, MC Asselin, N Nassoury, G Mayer, A Prat, ...
Hepatology 50 (1), 17-24, 2009
Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
G Mayer, S Poirier, NG Seidah
Journal of Biological Chemistry 283 (46), 31791-31801, 2008
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
N Nour, G Mayer, JS Mort, A Salvas, M Mbikay, CJ Morrison, CM Overall, ...
Molecular biology of the cell 16 (11), 5215-5226, 2005
PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver
A Demers, S Samami, B Lauzier, C Des Rosiers, ETN Sock, H Ong, ...
Arteriosclerosis, thrombosis, and vascular biology 35 (12), 2517-2525, 2015
Localization of Microsomal Triglyceride Transfer Protein in the Golgi POSSIBLE ROLE IN THE ASSEMBLY OF CHYLOMICRONS
E Levy, S Stan, E Delvin, D Ménard, C Shoulders, C Garofalo, I Slight, ...
Journal of Biological Chemistry 277 (19), 16470-16477, 2002
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
G Mayer, J Hamelin, MC Asselin, A Pasquato, E Marcinkiewicz, M Tang, ...
Journal of Biological Chemistry 283 (4), 2373-2384, 2008
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation
NG Seidah, S Poirier, M Denis, R Parker, B Miao, C Mapelli, A Prat, ...
PloS one 7 (7), e41865, 2012
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
S Poirier, G Mayer
Drug design, development and therapy 7, 1135, 2013
Furin interacts with proMT1-MMP and integrin αV at specialized domains of renal cell plasma membrane
G Mayer, G Boileau, M Bendayan
Journal of Cell Science 116 (9), 1763-1773, 2003
Biotinyl–tyramide: a novel approach for electron microscopic immunocytochemistry
G Mayer, M Bendayan
Journal of Histochemistry & Cytochemistry 45 (11), 1449-1454, 1997
Effects of the Prosegment and pH on the Activity of PCSK9 EVIDENCE FOR ADDITIONAL PROCESSING EVENTS
S Benjannet, YGL Saavedra, J Hamelin, MC Asselin, R Essalmani, ...
Journal of Biological Chemistry 285 (52), 40965-40978, 2010
Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other
C Butkinaree, M Canuel, R Essalmani, S Poirier, S Benjannet, MC Asselin, ...
Journal of Biological Chemistry 290 (30), 18609-18620, 2015
Sorting of furin in polarized epithelial and endothelial cells: expression beyond the Golgi apparatus
G Mayer, G Boileau, M Bendayan
Journal of Histochemistry & Cytochemistry 52 (5), 567-579, 2004
GRP94 regulates circulating cholesterol levels through blockade of PCSK9-induced LDLR degradation
S Poirier, M Mamarbachi, WT Chen, AS Lee, G Mayer
Cell reports 13 (10), 2064-2071, 2015
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism
S Poirier, S Samami, M Mamarbachi, A Demers, TY Chang, DE Vance, ...
Journal of biological chemistry 289 (27), 18736-18751, 2014
Immunogold signal amplification: application of the CARD approach to electron microscopy
G Mayer, M Bendayan
Journal of Histochemistry & Cytochemistry 47 (4), 421-429, 1999
Expression and localization of MT1-MMP and furin in the glomerular wall of short-and long-term diabetic rats
E Boucher, G Mayer, I Londono, M Bendayan
Kidney international 69 (9), 1570-1577, 2006
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