| The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 S Poirier, G Mayer, S Benjannet, E Bergeron, J Marcinkiewicz, ... Journal of Biological Chemistry 283 (4), 2363-2372, 2008 | 570 | 2008 |
| The activation and physiological functions of the proprotein convertases NG Seidah, G Mayer, A Zaid, E Rousselet, N Nassoury, S Poirier, ... The international journal of biochemistry & cell biology 40 (6-7), 1111-1125, 2008 | 401 | 2008 |
| Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route S Poirier, G Mayer, V Poupon, PS McPherson, R Desjardins, K Ly, ... Journal of biological chemistry 284 (42), 28856-28864, 2009 | 344 | 2009 |
| PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver A Demers, S Samami, B Lauzier, C Des Rosiers, ETN Sock, H Ong, ... Arteriosclerosis, thrombosis, and vascular biology 35 (12), 2517-2525, 2015 | 251 | 2015 |
| Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels G Mayer, S Poirier, NG Seidah Journal of Biological Chemistry 283 (46), 31791-31801, 2008 | 204 | 2008 |
| PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression P Labonté, S Begley, C Guévin, MC Asselin, N Nassoury, G Mayer, A Prat, ... Hepatology 50 (1), 17-24, 2009 | 197 | 2009 |
| The role of gut microbiota on cholesterol metabolism in atherosclerosis M Vourakis, G Mayer, G Rousseau International Journal of Molecular Sciences 22 (15), 8074, 2021 | 160 | 2021 |
| Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation NG Seidah, S Poirier, M Denis, R Parker, B Miao, C Mapelli, A Prat, ... PloS one 7 (7), e41865, 2012 | 140 | 2012 |
| The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases N Nour, G Mayer, JS Mort, A Salvas, M Mbikay, CJ Morrison, CM Overall, ... Molecular biology of the cell 16 (11), 5215-5226, 2005 | 135 | 2005 |
| The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol S Poirier, G Mayer Drug design, development and therapy, 1135-1148, 2013 | 119 | 2013 |
| The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates G Mayer, J Hamelin, MC Asselin, A Pasquato, E Marcinkiewicz, M Tang, ... Journal of Biological Chemistry 283 (4), 2373-2384, 2008 | 105 | 2008 |
| Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons E Levy, S Stan, E Delvin, D Ménard, C Shoulders, C Garofalo, I Slight, ... Journal of Biological Chemistry 277 (19), 16470-16477, 2002 | 99 | 2002 |
| GRP94 regulates circulating cholesterol levels through blockade of PCSK9-induced LDLR degradation S Poirier, M Mamarbachi, WT Chen, AS Lee, G Mayer Cell reports 13 (10), 2064-2071, 2015 | 88 | 2015 |
| Furin interacts with proMT1-MMP and integrin αV at specialized domains of renal cell plasma membrane G Mayer, G Boileau, M Bendayan Journal of Cell Science 116 (9), 1763-1773, 2003 | 86 | 2003 |
| Biotinyl–tyramide: a novel approach for electron microscopic immunocytochemistry G Mayer, M Bendayan Journal of Histochemistry & Cytochemistry 45 (11), 1449-1454, 1997 | 83 | 1997 |
| Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events S Benjannet, YGL Saavedra, J Hamelin, MC Asselin, R Essalmani, ... Journal of Biological Chemistry 285 (52), 40965-40978, 2010 | 80 | 2010 |
| Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other C Butkinaree, M Canuel, R Essalmani, S Poirier, S Benjannet, MC Asselin, ... Journal of Biological Chemistry 290 (30), 18609-18620, 2015 | 66 | 2015 |
| Effects of LDL receptor modulation on lymphatic function A Milasan, F Dallaire, G Mayer, C Martel Scientific reports 6 (1), 27862, 2016 | 60 | 2016 |
| Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery W Viricel, S Poirier, A Mbarek, RM Derbali, G Mayer, J Leblond Nanoscale 9 (1), 31-36, 2017 | 56 | 2017 |
| The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism S Poirier, S Samami, M Mamarbachi, A Demers, TY Chang, DE Vance, ... Journal of biological chemistry 289 (27), 18736-18751, 2014 | 54 | 2014 |
